CD218a (IL-18Ra) Monoclonal Antibody (P3TUNYA), eFluor™ 450, eBioscience™, Invitrogen™

Description

• This P3TUNYA MAb reacts with mouse CD218a (Interleukin 18 Receptor alpha), one of the subunits of heterodimeric receptor complex for the IL-18 cytokine
• IL-18 is a proinflammatory cytokine and member of IL-1 family first identified by its role in IFN gamma secretion during toxic shock
• Like other members of the family, it is synthesized as an inactive precursor which requires cleavage by caspases prior to secretion of the active form
• It is secreted by activated monocytes, macrophages, epithelial cells, and keratinocytes via a non-classical pathway
• IL-18 Receptor is expressed on Th1, but not naive CD4 T cells or Th2, as well as subsets of NK cells and neutrophils
• The heterodimeric receptor is made up of a ligand-binding alpha chain and signal-transducing beta chain
• On its own, IL-18Ra binds IL-18 with low affinity, although the affinity of this interaction increases upon forming a complex with IL-18Rb
• IL-18R signaling plays a critical role in Th1 differentiation and effector function, and results in increased expression of IFN gamma, TNF alpha, and Fas ligand from T cells and NK cells
• IL-18 has also been found to synergize with IL-23 in the development and function of Th17 cells
• Recently, a subset of CD8 T cells has been discovered that co-secretes IFN gamma with IL-17A and sometimes IL-22
• These Tc17 cells share key transcription factors, chemokine and cytokine receptors with Th17 cells
• In humans, this population has been identified by expression of CD161 and IL-18R
• IL18R1 is a cytokine receptor that belongs to the interleukin 1 receptor family
• This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction
• IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells
• The gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.