50-113-7520
Granzyme B Monoclonal Antibody (GB12), PE, Invitrogen™
Manufacturer: Invitrogen
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-113-7520-Each-of-1 | In Stock | ₹ 43,464.48 |
50-113-7520 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,464.48
GST (18%): ₹ 7,823.606
Total Price: ₹ 51,288.086
Antigen
Granzyme B
Classification
Monoclonal
Concentration
0.15 mg/mL
Formulation
PBS with 10% sucrose, 4mg/mL BSA and 0.1% sodium azide
Gene Accession No.
P10144
Gene Symbols
GZMB
Immunogen
Human Granzyme B.
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry
Clone
GB12
Conjugate
PE
Gene
GZMB
Gene Alias
AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
3002
Content And Storage
4° C
Form
Liquid
Related Products
Description
- According to the literature this antibody recognizes granzyme B1
- Each lot is tested by flow cytometry using peripheral blood leukocytes
- Based on this testing it is recommended that 5 μL of antibody be used per 1 x 10^6 cells
- For R-PE conjugates excitation 488 nm/peak emission 575 nm
- Matching isotype control is available: Ms IgG1 R-PE #MG104
- Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells
- Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells
- Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells
- The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis
- Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis
- Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein
- Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells
- A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
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Antigen: Granzyme B
Classification: Monoclonal
Concentration: 0.15 mg/mL
Formulation: PBS with 10% sucrose, 4mg/mL BSA and 0.1% sodium azide
Gene Accession No.: P10144
Gene Symbols: GZMB
Immunogen: Human Granzyme B.
Quantity: 500 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Flow Cytometry
Clone: GB12
Conjugate: PE
Gene: GZMB
Gene Alias: AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species: Mouse
Purification Method: purified
Regulatory Status: RUO
Gene ID (Entrez): 3002
Content And Storage: 4° C
Form: Liquid
Antigen:
Granzyme B
Classification:
Monoclonal
Concentration:
0.15 mg/mL
Formulation:
PBS with 10% sucrose, 4mg/mL BSA and 0.1% sodium azide
Gene Accession No.:
P10144
Gene Symbols:
GZMB
Immunogen:
Human Granzyme B.
Quantity:
500 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Flow Cytometry
Clone:
GB12
Conjugate:
PE
Gene:
GZMB
Gene Alias:
AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species:
Mouse
Purification Method:
purified
Regulatory Status:
RUO
Gene ID (Entrez):
3002
Content And Storage:
4° C
Form:
Liquid
Antigen: Granzyme B
Classification: Monoclonal
Concentration: 0.15 mg/mL
Formulation: PBS with 4mg/mL BSA, sucrose and 0.1% sodium azide
Gene Accession No.: P10144
Gene Symbols: GZMB
Immunogen: Human Granzyme B.
Quantity: 500 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Flow Cytometry
Clone: GB12
Conjugate: APC
Gene: GZMB
Gene Alias: AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species: Mouse
Purification Method: purified
Regulatory Status: RUO
Gene ID (Entrez): 3002
Content And Storage: 4° C
Form: Liquid
Antigen:
Granzyme B
Classification:
Monoclonal
Concentration:
0.15 mg/mL
Formulation:
PBS with 4mg/mL BSA, sucrose and 0.1% sodium azide
Gene Accession No.:
P10144
Gene Symbols:
GZMB
Immunogen:
Human Granzyme B.
Quantity:
500 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Flow Cytometry
Clone:
GB12
Conjugate:
APC
Gene:
GZMB
Gene Alias:
AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species:
Mouse
Purification Method:
purified
Regulatory Status:
RUO
Gene ID (Entrez):
3002
Content And Storage:
4° C
Form:
Liquid
Antigen: Perforin
Classification: Monoclonal
Concentration: __
Formulation: PBS with 0.1% sodium azide
Gene Accession No.: P14222
Gene Symbols: PRF1
Immunogen: Human Perforin.
Quantity: 500 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2b
Applications: Flow Cytometry
Clone: dG9
Conjugate: Alexa Fluor 647
Gene: PRF1
Gene Alias: Cyta; Cytolysin; FLH2; HPLH2; lymphocyte pore forming protein; lymphocyte pore-forming protein; OMAK; OTTHUMP00000019759; P1; perforin 1; perforin 1 (pore forming protein); Perforin1; perforin-1; Pfn; PFN1; Pfp; PGFL; PIGF; PIGF-2; PLGF; pore forming protein; pore-forming protein; PRF1; Prf-1; PRF1 (pore forming protein 1); RATCYTA; RP11-710A11.3
Host Species: Mouse
Purification Method: purified
Regulatory Status: RUO
Gene ID (Entrez): 5551
Content And Storage: 4° C
Form: Liquid
Antigen:
Perforin
Classification:
Monoclonal
Concentration:
__
Formulation:
PBS with 0.1% sodium azide
Gene Accession No.:
P14222
Gene Symbols:
PRF1
Immunogen:
Human Perforin.
Quantity:
500 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2b
Applications:
Flow Cytometry
Clone:
dG9
Conjugate:
Alexa Fluor 647
Gene:
PRF1
Gene Alias:
Cyta; Cytolysin; FLH2; HPLH2; lymphocyte pore forming protein; lymphocyte pore-forming protein; OMAK; OTTHUMP00000019759; P1; perforin 1; perforin 1 (pore forming protein); Perforin1; perforin-1; Pfn; PFN1; Pfp; PGFL; PIGF; PIGF-2; PLGF; pore forming protein; pore-forming protein; PRF1; Prf-1; PRF1 (pore forming protein 1); RATCYTA; RP11-710A11.3
Host Species:
Mouse
Purification Method:
purified
Regulatory Status:
RUO
Gene ID (Entrez):
5551
Content And Storage:
4° C
Form:
Liquid
Antigen: LPAM-1
Classification: Monoclonal
Concentration: 0.1 mg/mL
Formulation: PBS with <0.1% sodium azide
Gene Accession No.: P26011, Q00651
Gene Symbols: Itga4, Itgb7
Immunogen: Mouse LPAM-1.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: DATK32
Conjugate: PE
Gene: Itgb7
Gene Alias: CD49 antigen-like family member D; CD49D; integrin alpha 4; integrin alpha-4; integrin alpha4B; Integrin alpha-IV; integrin beta 7; integrin beta-7; Integrin beta-P; Itga4; Itga4B; Itgb7; LPAM subunit alpha; Ly69; lymphocyte Peyer patch adhesion molecules subunit alpha; M290 IEL antigen; VLA; VLA 4; VLA-4 receptor, alpha 4 subunit; VLA4 subunit alpha; VLA-4 subunit alpha
Host Species: Rat
Purification Method: purified
Regulatory Status: RUO
Gene ID (Entrez): 16401, 16421
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen:
LPAM-1
Classification:
Monoclonal
Concentration:
0.1 mg/mL
Formulation:
PBS with <0.1% sodium azide
Gene Accession No.:
P26011, Q00651
Gene Symbols:
Itga4, Itgb7
Immunogen:
Mouse LPAM-1.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
DATK32
Conjugate:
PE
Gene:
Itgb7
Gene Alias:
CD49 antigen-like family member D; CD49D; integrin alpha 4; integrin alpha-4; integrin alpha4B; Integrin alpha-IV; integrin beta 7; integrin beta-7; Integrin beta-P; Itga4; Itga4B; Itgb7; LPAM subunit alpha; Ly69; lymphocyte Peyer patch adhesion molecules subunit alpha; M290 IEL antigen; VLA; VLA 4; VLA-4 receptor, alpha 4 subunit; VLA4 subunit alpha; VLA-4 subunit alpha
Host Species:
Rat
Purification Method:
purified
Regulatory Status:
RUO
Gene ID (Entrez):
16401, 16421
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid