PGR Monoclonal Antibody (OTI5E8), TrueMAB™, OriGene

Description

• The progesterone receptor (PR) is a member of the steroid family of nuclear receptors
• The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintece of pregcy
• PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites
• PR-B is the transcriptionally active form and is responsible for activating genes for the maintece of the endometrium, maintece of pregcy, and inhibition of ovulation
• PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus
• This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity
• In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins
• Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription
• A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.