50-199-1703
Phospho-CHK2 (Thr68)Rabbit anti-Human, Polyclonal, Rockland™
Manufacturer: Rockland Immunochemicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-199-1703-Each-of-1 | In Stock | ₹ 50,884.24 |
50-199-1703 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,884.24
GST (18%): ₹ 9,159.163
Total Price: ₹ 60,043.403
Antigen
Phospho-CHK2 (Thr68)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Chek2
Gene Alias
CDS1; Cds1 homolog; Checkpoint kinase 2; checkpoint-like protein CHK2; Chek2; CHK2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; Hucds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; RAD53; Rad53 homolog; RP11-436C9.1; Serine/threonine-protein kinase Chk2
Host Species
Rabbit
Regulatory Status
RUO
Gene ID (Entrez)
11200
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.
O96017
Gene Symbols
Chek2
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Related Products
Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- This affinity purified antibody is directed against the phosphorylated form of human CHK2 at the pT68 residue
- Reactivity occurs against human CHK2 pT68 protein and the antibody is specific for the phosphorylated form of the protein
- Reactivity with non-phosphorylated human CHK2 is minimal by ELISA
- The antibody does not cross-react with Chk2 phosphorylated at other sites
- A BLAST analysis was used to suggest reactivity with this protein from human and chimpanzee based on 100% homology for the immunogen sequence
- Cross reactivity with CHK2 protein from mouse and rat may occur as sequence homology varies by one amino acid residues in this sequence (90% homology)
- Cross reactivity with CHK2 homologues from other sources has not been determined
- Checkpoint kinase 2 (Chk2) is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator
- ATM and ATR kinases are activated in response to ionizing and ultraviolet radition, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2 dimerisation and activation
- Activated Chk2 phosphorylates and inhibits Cdc25C phosphates, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1
- In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage
- Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53
- Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
Compare Similar Items
Show Difference
Antigen: Phospho-CHK2 (Thr68)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Chek2
Gene Alias: CDS1; Cds1 homolog; Checkpoint kinase 2; checkpoint-like protein CHK2; Chek2; CHK2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; Hucds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; RAD53; Rad53 homolog; RP11-436C9.1; Serine/threonine-protein kinase Chk2
Host Species: Rabbit
Regulatory Status: RUO
Gene ID (Entrez): 11200
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: ELISA, Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.: O96017
Gene Symbols: Chek2
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Antigen:
Phospho-CHK2 (Thr68)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Chek2
Gene Alias:
CDS1; Cds1 homolog; Checkpoint kinase 2; checkpoint-like protein CHK2; Chek2; CHK2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; Chk2 phospho; Chk2 phospho T68; del9; EC 2.7.11.1; hCds1; Hucds1; kinase Chk2; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; PP1425; protein kinase Chk2; RAD53; Rad53 homolog; RP11-436C9.1; Serine/threonine-protein kinase Chk2
Host Species:
Rabbit
Regulatory Status:
RUO
Gene ID (Entrez):
11200
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
ELISA, Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
O96017
Gene Symbols:
Chek2
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Antigen: MAPKAP Kinase 2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MAPKAPK2
Gene Alias: AA960234; MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAPK2; MAPKAP-K2; MAPKAPK-2; mitogen-activated protein kinase-activated protein kinase 2; MK2; MK-2; Rps6kc1
Host Species: Rabbit
Regulatory Status: RUO
Gene ID (Entrez): 17164, 289014, 9261
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration: 0.9 mg/mL
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.: P49137, P49138
Gene Symbols: MAPKAPK2
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Antigen:
MAPKAP Kinase 2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MAPKAPK2
Gene Alias:
AA960234; MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAPK2; MAPKAP-K2; MAPKAPK-2; mitogen-activated protein kinase-activated protein kinase 2; MK2; MK-2; Rps6kc1
Host Species:
Rabbit
Regulatory Status:
RUO
Gene ID (Entrez):
17164, 289014, 9261
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration:
0.9 mg/mL
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
P49137, P49138
Gene Symbols:
MAPKAPK2
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Antigen: Phospho-Rad9 (Ser1129)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: RAD9
Gene Alias: __
Host Species: Rabbit
Regulatory Status: RUO
Gene ID (Entrez): 851803
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: ELISA, Immunoprecipitation, Western Blot
Concentration: 0.43 mg/mL
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.: P14737
Gene Symbols: RAD9
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Yeast
Product Type: Antibody
Antigen:
Phospho-Rad9 (Ser1129)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
RAD9
Gene Alias:
__
Host Species:
Rabbit
Regulatory Status:
RUO
Gene ID (Entrez):
851803
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
ELISA, Immunoprecipitation, Western Blot
Concentration:
0.43 mg/mL
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
P14737
Gene Symbols:
RAD9
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Yeast
Product Type:
Antibody
Antigen: Rad9 S1129
Classification: Polyclonal
Conjugate: Unconjugated
Gene: RAD9
Gene Alias: __
Host Species: Rabbit
Regulatory Status: RUO
Gene ID (Entrez): 851803
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: ELISA, Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.: P14737
Gene Symbols: RAD9
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Yeast
Product Type: Antibody
Antigen:
Rad9 S1129
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
RAD9
Gene Alias:
__
Host Species:
Rabbit
Regulatory Status:
RUO
Gene ID (Entrez):
851803
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
ELISA, Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
P14737
Gene Symbols:
RAD9
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Yeast
Product Type:
Antibody