50-199-1739
Phospho-Mdm2 (Ser185)Rabbit anti-Human, Mouse, Rat, Polyclonal, Rockland™
Manufacturer: Rockland Immunochemicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-199-1739-Each-of-1 | In Stock | ₹ 50,884.24 |
50-199-1739 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,884.24
GST (18%): ₹ 9,159.163
Total Price: ₹ 60,043.403
Antigen
Phospho-Mdm2 (Ser185)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
1700007J15Rik; AA415488; ACTFS; double minute 2; Double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; Mdm2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; Oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species
Rabbit
Regulatory Status
RUO
Gene ID (Entrez)
17246, 314856, 4193
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.
P23804, Q00987
Gene Symbols
MDM2
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Related Products
Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- This affinity-purified antibody is directed against the phosphorylated form of mouse MDM2 protein at the pS185 residue
- Reactivity occurs against Mouse MDM2 pS185 protein and the antibody is specific for the phosphorylated form of the protein
- Reactivity with non-phosphorylated mouse MDM2 is minimal by ELISA and western blot
- A BLAST analysis was used to suggest minimal cross reactivity with MDM2 homologues from other sources
- MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human malignancies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
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Antigen: Phospho-Mdm2 (Ser185)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik; AA415488; ACTFS; double minute 2; Double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; Mdm2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; Oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species: Rabbit
Regulatory Status: RUO
Gene ID (Entrez): 17246, 314856, 4193
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: ELISA, Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.: P23804, Q00987
Gene Symbols: MDM2
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Antigen:
Phospho-Mdm2 (Ser185)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik; AA415488; ACTFS; double minute 2; Double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; Mdm2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; Oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species:
Rabbit
Regulatory Status:
RUO
Gene ID (Entrez):
17246, 314856, 4193
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
ELISA, Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
P23804, Q00987
Gene Symbols:
MDM2
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Antigen: __
Classification: __
Conjugate: __
Gene: __
Gene Alias: __
Host Species: __
Regulatory Status: __
Gene ID (Entrez): __
Content And Storage: __
Form: __
Applications: __
Concentration: __
Formulation: __
Gene Accession No.: __
Gene Symbols: __
Quantity: __
Primary or Secondary: __
Target Species: __
Product Type: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene:
__
Gene Alias:
__
Host Species:
__
Regulatory Status:
__
Gene ID (Entrez):
__
Content And Storage:
__
Form:
__
Applications:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Gene Symbols:
__
Quantity:
__
Primary or Secondary:
__
Target Species:
__
Product Type:
__
Antigen: Phospho-GSK3 beta (Ser9)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: GSK3B
Gene Alias: 7330414F15Rik; 8430431H08Rik; BOS_771; C86142; EC 2.7.11.26; FA; Factor A; fb68h05; fk80d11; glycogen synthase kinase 3; glycogen synthase kinase 3 beta; glycogen synthase kinase 3 beta L homeolog; glycogen synthase kinase 3 beta variant 1; glycogen synthase kinase 3 beta variant 2; glycogen synthase kinase 3 beta variant 3; glycogen synthase kinase 3 beta variant 4; glycogen synthase kinase 3 beta, genome duplicate a; Glycogen synthase kinase-3 beta; GSK 3 beta; GSK 3B; GSK3; gsk-3; GSK3 beta; GSK-3 beta; GSK-3 beta GSK3B; GSK-3[b]; GSK3B; GSK-3b; gsk3b.L; gsk3ba; GSK3beta; GSK-3beta; gsk3-beta; GSK3beta isoform; intracellular kinase; pp37; Serine/threonine-protein kinase GSK3B; wu:fb68h05; wu:fk80d11; XELAEV_180112401mg; Xgsk-3; Xgsk-3 protein
Host Species: Rabbit
Regulatory Status: RUO
Gene ID (Entrez): 2932
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: ELISA, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.: P49841
Gene Symbols: GSK3B
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Antigen:
Phospho-GSK3 beta (Ser9)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
GSK3B
Gene Alias:
7330414F15Rik; 8430431H08Rik; BOS_771; C86142; EC 2.7.11.26; FA; Factor A; fb68h05; fk80d11; glycogen synthase kinase 3; glycogen synthase kinase 3 beta; glycogen synthase kinase 3 beta L homeolog; glycogen synthase kinase 3 beta variant 1; glycogen synthase kinase 3 beta variant 2; glycogen synthase kinase 3 beta variant 3; glycogen synthase kinase 3 beta variant 4; glycogen synthase kinase 3 beta, genome duplicate a; Glycogen synthase kinase-3 beta; GSK 3 beta; GSK 3B; GSK3; gsk-3; GSK3 beta; GSK-3 beta; GSK-3 beta GSK3B; GSK-3[b]; GSK3B; GSK-3b; gsk3b.L; gsk3ba; GSK3beta; GSK-3beta; gsk3-beta; GSK3beta isoform; intracellular kinase; pp37; Serine/threonine-protein kinase GSK3B; wu:fb68h05; wu:fk80d11; XELAEV_180112401mg; Xgsk-3; Xgsk-3 protein
Host Species:
Rabbit
Regulatory Status:
RUO
Gene ID (Entrez):
2932
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
ELISA, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
P49841
Gene Symbols:
GSK3B
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Antigen: AKT2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Akt2
Gene Alias: 2410016A19Rik; AKT serine/threonine kinase 2; Akt2; AKT2 kinase; AW554154; HIHGHH; murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 2; PKB; PKB beta; PKBB; PKBbeta; PRKBB; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; putative v-akt murine thymoma viral oncoprotein 2; rac protein kinase beta; RAC protein kinase beta RAC-PK beta; RAC-BETA; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2
Host Species: Rabbit
Regulatory Status: RUO
Gene ID (Entrez): 208
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: ELISA, Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.: P31751
Gene Symbols: Akt2
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Antigen:
AKT2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Akt2
Gene Alias:
2410016A19Rik; AKT serine/threonine kinase 2; Akt2; AKT2 kinase; AW554154; HIHGHH; murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 2; PKB; PKB beta; PKBB; PKBbeta; PRKBB; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; putative v-akt murine thymoma viral oncoprotein 2; rac protein kinase beta; RAC protein kinase beta RAC-PK beta; RAC-BETA; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2
Host Species:
Rabbit
Regulatory Status:
RUO
Gene ID (Entrez):
208
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
ELISA, Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.:
P31751
Gene Symbols:
Akt2
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody