HAX1Rabbit anti-Chicken, Human, Mouse, Non-human primate, Rat, Polyclonal, Rockland™

Description

• Store vial at -20°C prior to opening
• Aliquot contents and freeze at -20°C or below for extended storage
• Avoid cycles of freezing and thawing
• Centrifuge product if not completely clear after standing at room temperature
• This product is stable for several weeks at 4°C as an undiluted liquid
• Dilute only prior to immediate use
• Anti-HAX1 was affinity purified from monospecific antiserum by immunoaffinity chromatography
• A BLAST analysis was used to suggest cross-reactivity with human, rat, and mouse based on 100% sequence homology
• Cross-reactivity with HAX1 from other sources has not been determined
• The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases
• It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin
• It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body
• Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease
• Two transcript variants encoding different isoforms have been found for this gene.