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50-245-903

CD85d (ILT4) Monoclonal Antibody (42D1), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Manufacturer: Invitrogen

Select a Size

Pack Size SKU Availability Price
Each of 1 50-245-903-Each-of-1 In Stock ₹ 13,946.28

50-245-903 - Each of 1

₹ 13,946.28

In Stock

Quantity

1

Base Price: ₹ 13,946.28

GST (18%): ₹ 2,510.33

Total Price: ₹ 16,456.61

Antigen

CD85d (ILT4)

Classification

Monoclonal

Concentration

5 μL/Test

Formulation

PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.

Q8N423

Gene Symbols

LILRB2

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

10288

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

Applications

Flow Cytometry

Clone

42D1

Conjugate

PerCP-eFluor 710

Gene

LILRB2

Gene Alias

CD85 antigen-like family member D; CD85D; CD85d antigen; Ig-like transcript 4; ILT4; ILT-4; leucocyte Ig-like receptor B2; leukocyte immunoglobulin like receptor B2; leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; LILRB2; Lilrb3; LIR2; LIR-2; LIR2CD85D; MIR10; MIR-10; MIR10LILRA6; monocyte/macrophage immunoglobulin-like receptor 10; myeloid inhibitory receptor 10; Neutrophil immunoglobulin-like receptor 1; Nilr1; NILR-1; paired-Ig-like receptor B; Pirb; type 1 one-pass transmembrane Ig-like receptor

Host Species

Rat

Quantity

25 Tests

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG2a κ

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Description

  • Description: The monoclonal antibody 42D1 recognizes the CD85d protein also known as ILT4, LIR-2
  • It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leukocyte Ig-like receptor), MIR (monocytes Ig-like receptor) family
  • CD85d is a 110 kDa single transmembrane receptor with 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs)
  • Expression is confined to monocytes, macrophages and dendritic cells
  • The ligand for CD85d is non-classical class I HLA-G, -B and G1
  • Upon ligand binding, tyrosine phosphatase SHP-1 interacts with the ITIM
  • Interaction of HLA-G with ILT4/CD85d is thought to contribute to tolerance during fetal implantation
  • Additionally, it is the levels of ILT3 and ILT4 on DCs that suggests a role in organ allograft rejection
  • Crosslinking of the receptor with the monoclonal antibody 42D1 inhibits calcium flux as well as enhancing HLA-G tetramer staining and restoring the stimulating activity of tolerogenic DC
  • Applications Reported: This 42D1 antibody has been reported for use in flow cytometric analysis
  • Applications Tested: This 42D1 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
  • This can be used at 5 μL (0.125 μg) per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • LILRB2 (ILT4) gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4
  • The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs)
  • The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response
  • It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity
  • Multiple transcript variants encoding different isoforms have been found for this gene.

Compare Similar Items

Show Difference

Img

Invitrogen

50-245-903

--

Antigen:
CD85d (ILT4)
Classification:
Monoclonal
Concentration:
5 μL/Test
Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q8N423
Gene Symbols:
LILRB2
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10288
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
42D1
Conjugate:
PerCP-eFluor 710
Gene:
LILRB2
Gene Alias:
CD85 antigen-like family member D; CD85D; CD85d antigen; Ig-like transcript 4; ILT4; ILT-4; leucocyte Ig-like receptor B2; leukocyte immunoglobulin like receptor B2; leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; LILRB2; Lilrb3; LIR2; LIR-2; LIR2CD85D; MIR10; MIR-10; MIR10LILRA6; monocyte/macrophage immunoglobulin-like receptor 10; myeloid inhibitory receptor 10; Neutrophil immunoglobulin-like receptor 1; Nilr1; NILR-1; paired-Ig-like receptor B; Pirb; type 1 one-pass transmembrane Ig-like receptor
Host Species:
Rat
Quantity:
25 Tests
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a κ

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eMolecules​

50-245-9035

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eMolecules​

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eMolecules​

50-245-9040

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