50-245-915

TCR V beta 13 Monoclonal Antibody (MR12-3), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Manufacturer: Invitrogen

Select a Size

Pack Size SKU Availability Price
Each of 1 50-245-915-Each-of-1 In Stock ₹ 13,347.36

50-245-915 - Each of 1

₹ 13,347.36

In Stock

Quantity

1

Base Price: ₹ 13,347.36

GST (18%): ₹ 2,402.525

Total Price: ₹ 15,749.885

Antigen

TCR V beta 13

Classification

Monoclonal

Concentration

0.2 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Host Species

Mouse

Quantity

25 μg

Primary or Secondary

Primary

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

Applications

Flow Cytometry

Clone

MR12-3

Conjugate

PerCP-eFluor 710

Gene Alias

TCR V beta13; TCRV beta 13; TCRV beta13; Vb13; Vbeta13

Purification Method

Affinity chromatography

Regulatory Status

RUO

Target Species

Mouse

Product Type

Antibody

Isotype

IgG1 κ

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Description

  • Description: This MR12-3 monoclonal antibody reacts with the T cell receptor (TCR) V beta 13 chain
  • Composed of an alpha and beta chain, TCR specificity is typically determined by Va, Ja, Vb, Db, and Jb gene rearrangement
  • The MR12-3 antibody recognizes the V beta 13 chains on T cells from mouse strains with the b haplotype of the Tcrb gene, including C57BL/6, B10, and C3H
  • V beta 13+ T cells are deleted in mouse strains with the a (e.g., SJL) and c (e.g., RIIIS/J) haplotypes
  • The MR12-3 monoclonal antibody has been reported to have blocking activity
  • Applications Reported: This MR12-3 antibody has been reported for use in flow cytometric analysis and functional assays
  • Applications Tested: This MR12-3 antibody has been tested by flow cytometric analysis of mouse splenocytes
  • This can be used at less than or equal to 0.125 μg per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
  • PerCP-eFluor™ 710 can be used in place of PE-Cy5, PE-Cy5.5 or PerCP-Cy5.5
  • PerCP-eFluor™ 710 emits at 710 nm and is excited with the blue laser (488 nm)
  • Please make sure that your instrument is capable of detecting this fluorochrome
  • The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response
  • TCR recognition of self-peptides has been linked to autoimmune disease
  • Mutant self-peptides have been associated with tumors
  • Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome
  • Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)
  • The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease
  • Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP)
  • A small number of T cells lack both CD4 and CD8 (double negative, DN)
  • Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders
  • Gamma-delta T cells are primarily found within the epithelium
  • They show less TCR diversity and recognize antigens differently than alpha-beta T cells
  • Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Compare Similar Items

Show Difference

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Invitrogen

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Antigen:
TCR V beta 13

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Host Species:
Mouse

Quantity:
25 μg

Primary or Secondary:
Primary

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
MR12-3

Conjugate:
PerCP-eFluor 710

Gene Alias:
TCR V beta13; TCRV beta 13; TCRV beta13; Vb13; Vbeta13

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Target Species:
Mouse

Product Type:
Antibody

Isotype:
IgG1 κ

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eMolecules​

50-245-9152

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