CCL3 (MIP-1 alpha) Monoclonal Antibody (DNT3CC), eFluor™ 660, eBioscience™, Invitrogen™

Description

• This DNT3CC MAb reacts with mouse CCL3
• CCL3, also known as MIP-1 alpha (Macrophage Inflammatory Protein 1 alpha), is a member of the CC- subfamily of chemokines and is most closely related to CCL4, or MIP-1 beta
• These proteins play critical roles in the recruitment of leukocytes to the site of inflammation
• While both CCL3 and CCL4 will attract monocytes, macrophages, and dendritic cells, CCL3 preferentially attracts CD8+ T cells, while CD4+ T cells are more responsive to CCL4
• In addition to its chemotactic functions, CCL3 induces inflammatory cytokine secretion, mast cell degranulation, and NK cell activation
• It has also been reported to inhibit hematopoetic stem cell proliferation and may be responsible for the maintenance of these cells in a quiescent state
• CCL3 signaling is mediated by the G protein-coupled receptors CCR1, CCR4, and CCR5, which are shared with CCL4 and CCL5 (RANTES)
• Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines
• They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g
• macrophages, lymphocytes and NK cells)
• While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes
• Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells
• Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.