EGFR Monoclonal Antibody (me1B3), eFluor™ 660, eBioscience™, Invitrogen™

Description

• This me1B3 MAb reacts with human epidermal growth factor receptor (EGFR), also known as ErbB1 and Her1
• EGFR is a receptor tyrosine kinase belonging to the EGFR/ErbB receptor subfamily, which also includes ErbB2/Her2/neu
• EGFR contains an extracellular ligand-binding domain, a single transmembrane-spanning region, and a cytoplasmic tail containing a tyrosine kinase domain
• Specific ligands include EGF and TNF alpha, as well as other members of the EGF protein family
• Upon ligand binding, EGFR undergoes receptor-mediated dimerization with itself or ErbB2/Her2/neu
• Dimerization induces auto-phosphorylation, resulting in the activation of PLC gamma, JAK/STAT, MAPK/ERK, and PI3K/AKT signaling pathways
• EGFR has a role in cell proliferation, migration and differentiation, and is evolutionarily highly conserved in structure and function
• EGFR is broadly expressed and is overexpressed or mutated in glioblastomas and a number of different epithelial cancers, including non-small cell lung cancer and colorectal cancer
• EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors
• Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics
• EGFR is encoded by the EGFR gene located on chromosome 7 in humans
• EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4
• EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain
• Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.