53-575-182
MERTK Monoclonal Antibody (DS5MMER), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 53-575-182-Each-of-1 | In Stock | ₹ 27,464.76 |
53-575-182 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 27,464.76
GST (18%): ₹ 4,943.657
Total Price: ₹ 32,408.417
Antigen
MERTK
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q60805
Gene Symbols
Mertk
Immunogen
FC-tagged full protein expressed in insect cells
Quantity
100μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
DS5MMER
Conjugate
Alexa Fluor 488
Gene
Mertk
Gene Alias
c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
Host Species
Rat
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17289
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Description
- This DS5MMER monoclonal antibody recognizes mouse MerTK, a 170-210 kDa member of the TAM family of tyrosine kinase receptors that also includes Axl and Tyro3
- MerTK is expressed on tissue macrophages and is involved in the removal of apoptotic cells
- This MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease
- Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis)
- Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules
- Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1
- MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment
- Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis
- Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Compare Similar Items
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Antigen: MERTK
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: Q60805
Gene Symbols: Mertk
Immunogen: FC-tagged full protein expressed in insect cells
Quantity: 100μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: DS5MMER
Conjugate: Alexa Fluor 488
Gene: Mertk
Gene Alias: c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
Host Species: Rat
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17289
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen:
MERTK
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q60805
Gene Symbols:
Mertk
Immunogen:
FC-tagged full protein expressed in insect cells
Quantity:
100μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
DS5MMER
Conjugate:
Alexa Fluor 488
Gene:
Mertk
Gene Alias:
c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
Host Species:
Rat
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17289
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Antigen: VSIG4
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: 0
Gene Symbols: VSIG4
Immunogen: __
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: NLA14
Conjugate: Alexa Fluor 488
Gene: VSIG4
Gene Alias: A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG
Host Species: Rat
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 278180
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen:
VSIG4
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
0
Gene Symbols:
VSIG4
Immunogen:
__
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
NLA14
Conjugate:
Alexa Fluor 488
Gene:
VSIG4
Gene Alias:
A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG
Host Species:
Rat
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
278180
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Antigen: CD169 (Siglec-1)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.: Q62230
Gene Symbols: SIGLEC1
Immunogen: __
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: SER-4
Conjugate: Alexa Fluor 488
Gene: SIGLEC1
Gene Alias: Cd169, dJ1009E24.1, macrophage receptor, p210, pSn, SA, SER, sheep erythrocyte receptor, sialic acid binding Ig like lectin 1, sialic acid binding Ig-like lectin 1, sialoadhesin, Sialic acid-binding Ig-like lectin 1, sialic acid-binding immunoglobulin-like lectin 1, sialoadhesin, SIGLEC1, Siglec-1, SN
Host Species: Rat
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20612
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen:
CD169 (Siglec-1)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.:
Q62230
Gene Symbols:
SIGLEC1
Immunogen:
__
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
SER-4
Conjugate:
Alexa Fluor 488
Gene:
SIGLEC1
Gene Alias:
Cd169, dJ1009E24.1, macrophage receptor, p210, pSn, SA, SER, sheep erythrocyte receptor, sialic acid binding Ig like lectin 1, sialic acid binding Ig-like lectin 1, sialoadhesin, Sialic acid-binding Ig-like lectin 1, sialic acid-binding immunoglobulin-like lectin 1, sialoadhesin, SIGLEC1, Siglec-1, SN
Host Species:
Rat
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20612
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Antigen: Endomucin
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.: Q9R0H2
Gene Symbols: Emcn
Immunogen: __
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: eBioV.7C7 (V.7C7)
Conjugate: Alexa Fluor 488
Gene: Emcn
Gene Alias: 0610012K22Rik, AI315669, Emcn, EMCN2, Endomucin, endomucin-1, endomucin-1/2, Endomucin-2, gastric cancer antigen Ga34, Muc14, MUC-14, mucin 14, endothelial, mucin-14, sialomucin
Host Species: Rat
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 59308
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen:
Endomucin
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.:
Q9R0H2
Gene Symbols:
Emcn
Immunogen:
__
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
eBioV.7C7 (V.7C7)
Conjugate:
Alexa Fluor 488
Gene:
Emcn
Gene Alias:
0610012K22Rik, AI315669, Emcn, EMCN2, Endomucin, endomucin-1, endomucin-1/2, Endomucin-2, gastric cancer antigen Ga34, Muc14, MUC-14, mucin 14, endothelial, mucin-14, sialomucin
Host Species:
Rat
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
59308
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid