53-575-282
VSIG4 Monoclonal Antibody (NLA14), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Manufacturer: eBioscience
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 53-575-282-Each-of-1 | In Stock | ₹ 33,197.28 |
53-575-282 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,197.28
GST (18%): ₹ 5,975.51
Total Price: ₹ 39,172.79
Antigen
VSIG4
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
0
Gene Symbols
VSIG4
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
278180
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
NLA14
Conjugate
Alexa Fluor 488
Gene
VSIG4
Gene Alias
A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: This NLA14 monoclonal antibody recognizes mouse V-Set and Immunoglobulin domain containing 4 (VSIG4), also known as Complement Receptor of the Immunoglobulin superfamily (CRIg) or Z39Ig
- VSIG4 is a type I transmembrane glycoprotein structurally related to the B7 family of immune regulatory proteins
- It contains one complete V-type Ig domain and one truncated C-type Ig domain
- VSIG4 is exclusively expressed on tissue resident and tumor infiltrating macrophages
- It has been shown to bind complement components C3b and iC3b
- This binding inhibits the alternative complement pathway and facilitates phagocytosis of complement-opsonized pathogens
- VSIG4 has also been reported to suppress T cell activation, proliferation and IL-2 production thereby playing a role in the maintece of peripheral T cell tolerance and suppression of established inflammation
- Expression of VSIG4 on tumor-infiltrating macrophages suggests its role in immune evasion
- Pro-inflammatory stimuli such as TNF and LPS have been reported to down-regulate the expression of VSIG4
- Peritoneal macrophages in Balb/c mice express significantly higher levels of VSIG4 than such macrophages in C57Bl/6 or Swiss Webster mice
- The NLA14 antibody will recognize VSIG4 on cells that have been formaldehyde-fixed and permeabilized
- This antibody does not block the ligation of VSIG4 to its T cell ligand
- The NLA14 antibody does not cross-react with rat or human VSIG4
- T cell activation by APCs is positively and negatively regulated by members of the B7 family
- VSIG4 is a strong negative regulator of murine and human T cell proliferation and IL-2 production.
Compare Similar Items
Show Difference
Antigen: VSIG4
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: 0
Gene Symbols: VSIG4
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 278180
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: NLA14
Conjugate: Alexa Fluor 488
Gene: VSIG4
Gene Alias: A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG
Host Species: Rat
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Antigen:
VSIG4
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
0
Gene Symbols:
VSIG4
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
278180
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
NLA14
Conjugate:
Alexa Fluor 488
Gene:
VSIG4
Gene Alias:
A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Antigen: CD169 (Siglec-1)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.: Q62230
Gene Symbols: SIGLEC1
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 20612
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: SER-4
Conjugate: Alexa Fluor 488
Gene: SIGLEC1
Gene Alias: Cd169, dJ1009E24.1, macrophage receptor, p210, pSn, SA, SER, sheep erythrocyte receptor, sialic acid binding Ig like lectin 1, sialic acid binding Ig-like lectin 1, sialoadhesin, Sialic acid-binding Ig-like lectin 1, sialic acid-binding immunoglobulin-like lectin 1, sialoadhesin, SIGLEC1, Siglec-1, SN
Host Species: Rat
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Antigen:
CD169 (Siglec-1)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.:
Q62230
Gene Symbols:
SIGLEC1
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
20612
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
SER-4
Conjugate:
Alexa Fluor 488
Gene:
SIGLEC1
Gene Alias:
Cd169, dJ1009E24.1, macrophage receptor, p210, pSn, SA, SER, sheep erythrocyte receptor, sialic acid binding Ig like lectin 1, sialic acid binding Ig-like lectin 1, sialoadhesin, Sialic acid-binding Ig-like lectin 1, sialic acid-binding immunoglobulin-like lectin 1, sialoadhesin, SIGLEC1, Siglec-1, SN
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Antigen: Endomucin
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.: Q9R0H2
Gene Symbols: Emcn
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 59308
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: eBioV.7C7 (V.7C7)
Conjugate: Alexa Fluor 488
Gene: Emcn
Gene Alias: 0610012K22Rik, AI315669, Emcn, EMCN2, Endomucin, endomucin-1, endomucin-1/2, Endomucin-2, gastric cancer antigen Ga34, Muc14, MUC-14, mucin 14, endothelial, mucin-14, sialomucin
Host Species: Rat
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Antigen:
Endomucin
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.:
Q9R0H2
Gene Symbols:
Emcn
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
59308
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
eBioV.7C7 (V.7C7)
Conjugate:
Alexa Fluor 488
Gene:
Emcn
Gene Alias:
0610012K22Rik, AI315669, Emcn, EMCN2, Endomucin, endomucin-1, endomucin-1/2, Endomucin-2, gastric cancer antigen Ga34, Muc14, MUC-14, mucin 14, endothelial, mucin-14, sialomucin
Host Species:
Rat
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ
Antigen: TIM-4
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: Q6U7R4
Gene Symbols: TIMD4
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 276891
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Flow Cytometry
Clone: 54 (RMT4-54)
Conjugate: Alexa Fluor 488
Gene: TIMD4
Gene Alias: B430010N18Rik; RGD1564516; smuckler; soluble TIM 4; Spleen, mucin-containing, knockout of lymphotoxin protein; sTIM 4; T cell immunoglobulin and mucin domain containing 4; T-cell immunoglobulin and mucin domain containing 4; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell immunoglobulin mucin receptor 4; T-cell membrane protein 4; Tim4; TIM-4; TIMD4; TIMD-4
Host Species: Rat
Quantity: 25 μg
Primary or Secondary: Primary
Target Species: Mouse
Product Type: Antibody
Isotype: IgG2a κ
Antigen:
TIM-4
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
Q6U7R4
Gene Symbols:
TIMD4
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
276891
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Flow Cytometry
Clone:
54 (RMT4-54)
Conjugate:
Alexa Fluor 488
Gene:
TIMD4
Gene Alias:
B430010N18Rik; RGD1564516; smuckler; soluble TIM 4; Spleen, mucin-containing, knockout of lymphotoxin protein; sTIM 4; T cell immunoglobulin and mucin domain containing 4; T-cell immunoglobulin and mucin domain containing 4; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell immunoglobulin mucin receptor 4; T-cell membrane protein 4; Tim4; TIM-4; TIMD4; TIMD-4
Host Species:
Rat
Quantity:
25 μg
Primary or Secondary:
Primary
Target Species:
Mouse
Product Type:
Antibody
Isotype:
IgG2a κ