5350514
MilliporeSigma™ anti-TIGIT, APC, Clone: 1G9,
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
TIGIT
Applications
Flow Cytometry
Conjugate
APC
Host Species
Mouse
Research Discipline
Inflammation, Immunology
Formulation
Purified Mouse monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols
Tigit
Primary or Secondary
Primary
Content And Storage
2°C to 8°C for one year from date of shipment protected from light; Do not freeze
Clone
1G9
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Mouse
Gene Accession No.
P86176
Immunogen
Proprietary immunogen
Purification Method
Purified by size-exclusion chromatography
Related Products
Description
- Specifically detects TIGIT Clone: 1G9 in Mouse samples, and it is validated for Flow Cytometry The 1G9 antibody reacts with mouse TIGIT (T cell Ig and ITIM domain), a 26kDa member of the CD28 receptor family which is reported to regulate T cell receptor (TCR) activation
- Within the CD28 family of receptors there are those which have co-stimulatory activity, such as CD28 and CTLA-4, as well as more recently identified receptors like TIGIT which are proposed to provide co-inhibitory signals
- TIGIT is expressed and upregulated on activated T cells, and is also expressed on memory and regulatory T cells
- Upon engagement by its ligands, CD112 and CD155, TIGIT signaling inhibits T cell proliferation and suppresses T cell responses, without triggering cell deletion
- A second inhibitory effect of TIGIT signaling is the generation of immunoregulatory dendritic cells, which secrete IL-10 and TGF-beta to further inhibit T cell function.The 1G9 antibody may be used for flow cytometric analysis of TIGIT, which is expressed at very high levels on T regulatory cells (Tregs) and activated conventional T cells, as well as memory T cells and NK cells.
Compare Similar Items
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Antigen: TIGIT
Applications: Flow Cytometry
Conjugate: APC
Host Species: Mouse
Research Discipline: Inflammation, Immunology
Formulation: Purified Mouse monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols: Tigit
Primary or Secondary: Primary
Content And Storage: 2°C to 8°C for one year from date of shipment protected from light; Do not freeze
Clone: 1G9
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Accession No.: P86176
Immunogen: Proprietary immunogen
Purification Method: Purified by size-exclusion chromatography
Antigen:
TIGIT
Applications:
Flow Cytometry
Conjugate:
APC
Host Species:
Mouse
Research Discipline:
Inflammation, Immunology
Formulation:
Purified Mouse monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols:
Tigit
Primary or Secondary:
Primary
Content And Storage:
2°C to 8°C for one year from date of shipment protected from light; Do not freeze
Clone:
1G9
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Accession No.:
P86176
Immunogen:
Proprietary immunogen
Purification Method:
Purified by size-exclusion chromatography
Antigen: F4/80
Applications: Flow Cytometry
Conjugate: FITC
Host Species: Rat
Research Discipline: Inflammation, Immunology
Formulation: Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols: Emr1, Gpf480
Primary or Secondary: Primary
Content And Storage: 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Clone: BM8.1
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Accession No.: Q61549
Immunogen: Proprietary immunogen
Purification Method: Purified by size-exclusion chromatography
Antigen:
F4/80
Applications:
Flow Cytometry
Conjugate:
FITC
Host Species:
Rat
Research Discipline:
Inflammation, Immunology
Formulation:
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols:
Emr1, Gpf480
Primary or Secondary:
Primary
Content And Storage:
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Clone:
BM8.1
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Accession No.:
Q61549
Immunogen:
Proprietary immunogen
Purification Method:
Purified by size-exclusion chromatography
Antigen: F4/80
Applications: Flow Cytometry
Conjugate: FITC
Host Species: Rat
Research Discipline: Inflammation, Immunology
Formulation: Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols: Emr1, Gpf480
Primary or Secondary: Primary
Content And Storage: 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Clone: BM8.1
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Accession No.: Q61549
Immunogen: Proprietary immunogen
Purification Method: Purified by size-exclusion chromatography
Antigen:
F4/80
Applications:
Flow Cytometry
Conjugate:
FITC
Host Species:
Rat
Research Discipline:
Inflammation, Immunology
Formulation:
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols:
Emr1, Gpf480
Primary or Secondary:
Primary
Content And Storage:
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Clone:
BM8.1
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Accession No.:
Q61549
Immunogen:
Proprietary immunogen
Purification Method:
Purified by size-exclusion chromatography
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Gene Accession No.:
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Immunogen:
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