5539499
CD27 Ligand/TNFSF7/CD70 Antibody (BU69), Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
CD27 Ligand/TNFSF7/CD70
Concentration
0.2 mg/mL
Applications
Flow Cytometry, Immunoprecipitation, Immunohistochemistry (Frozen), Immunofluorescence
Conjugate
Unconjugated
Host Species
Mouse
Research Discipline
Apoptosis
Formulation
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez)
970
Immunogen
Human WM-1 (Waldenstrom s macroglobulinemia) cell line
Primary or Secondary
Primary
Content And Storage
Store at 4C.
Molecular Weight of Antigen
30 kDa
Clone
BU69
Dilution
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunoprecipitation 0.5 - 1 ug/500ug Protein Lysate, Immunohistochemistry-Frozen 0.5 - 1 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Human
Gene Alias
CD27-L, CD27LCD27 ligand, CD27LG, CD70, CD70 molecule, Ki-24 antigen, surface antigen CD70, TNFSF7CD70 antigen, tumor necrosis factor (ligand) superfamily, member 7, Tumor necrosis factor ligand superfamily member 7
Gene Symbols
CD70
Isotype
IgG1 κ
Purification Method
Protein A or G purified
Test Specificity
It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells.
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Description
- Ensure accurate, reproducible results in ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Immunofluorescence CD27 Ligand/TNFSF7/CD70 Monoclonal specifically detects CD27 Ligand/TNFSF7/CD70 in Human samples
- It is validated for Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Frozen, Immunofluorescence.
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Antigen: CD27 Ligand/TNFSF7/CD70
Concentration: 0.2 mg/mL
Applications: Flow Cytometry, Immunoprecipitation, Immunohistochemistry (Frozen), Immunofluorescence
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Apoptosis
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez): 970
Immunogen: Human WM-1 (Waldenstrom s macroglobulinemia) cell line
Primary or Secondary: Primary
Content And Storage: Store at 4C.
Molecular Weight of Antigen: 30 kDa
Clone: BU69
Dilution: Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunoprecipitation 0.5 - 1 ug/500ug Protein Lysate, Immunohistochemistry-Frozen 0.5 - 1 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: CD27-L, CD27LCD27 ligand, CD27LG, CD70, CD70 molecule, Ki-24 antigen, surface antigen CD70, TNFSF7CD70 antigen, tumor necrosis factor (ligand) superfamily, member 7, Tumor necrosis factor ligand superfamily member 7
Gene Symbols: CD70
Isotype: IgG1 κ
Purification Method: Protein A or G purified
Test Specificity: It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells.
Antigen:
CD27 Ligand/TNFSF7/CD70
Concentration:
0.2 mg/mL
Applications:
Flow Cytometry, Immunoprecipitation, Immunohistochemistry (Frozen), Immunofluorescence
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Apoptosis
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene ID (Entrez):
970
Immunogen:
Human WM-1 (Waldenstrom s macroglobulinemia) cell line
Primary or Secondary:
Primary
Content And Storage:
Store at 4C.
Molecular Weight of Antigen:
30 kDa
Clone:
BU69
Dilution:
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunoprecipitation 0.5 - 1 ug/500ug Protein Lysate, Immunohistochemistry-Frozen 0.5 - 1 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
CD27-L, CD27LCD27 ligand, CD27LG, CD70, CD70 molecule, Ki-24 antigen, surface antigen CD70, TNFSF7CD70 antigen, tumor necrosis factor (ligand) superfamily, member 7, Tumor necrosis factor ligand superfamily member 7
Gene Symbols:
CD70
Isotype:
IgG1 κ
Purification Method:
Protein A or G purified
Test Specificity:
It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells.
Antigen: CD30/TNFRSF8
Concentration: 0.2mg/mL
Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Apoptosis, Cell Cycle and Replication, Embryonic Stem Cell Markers, Immunology, Stem Cell Markers
Formulation: No buffer with 0.05% Sodium Azide
Gene ID (Entrez): 943
Immunogen: Co cell line established from a patient with Hodgkin's disease of T-cell lineage (Ber-H2); human CD30 recombinant protein (CD30/412)
Primary or Secondary: Primary
Content And Storage: Store at 4C.
Molecular Weight of Antigen: __
Clone: Ber-H2 + CD30/412
Dilution: Flow Cytometry 5 - 10 ul/million cells in 0.1ml, Immunohistochemistry-Paraffin 1:100-1:200, Immunofluorescence 1:50 - 1:100
Classification: Monoclonal
Form: Supernatant
Regulatory Status: RUO
Target Species: Human
Gene Alias: CD30, CD30 antigen, CD30KI-1, CD30L receptor, cytokine receptor CD30, D1S166EKi-1, Ki-1 antigen, Lymphocyte activation antigen CD30, tumor necrosis factor receptor superfamily member 8, tumor necrosis factor receptor superfamily, member 8
Gene Symbols: TNFRSF8
Isotype: IgG
Purification Method: Tissue culture supernatant
Test Specificity: Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkins disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
Antigen:
CD30/TNFRSF8
Concentration:
0.2mg/mL
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Apoptosis, Cell Cycle and Replication, Embryonic Stem Cell Markers, Immunology, Stem Cell Markers
Formulation:
No buffer with 0.05% Sodium Azide
Gene ID (Entrez):
943
Immunogen:
Co cell line established from a patient with Hodgkin's disease of T-cell lineage (Ber-H2); human CD30 recombinant protein (CD30/412)
Primary or Secondary:
Primary
Content And Storage:
Store at 4C.
Molecular Weight of Antigen:
__
Clone:
Ber-H2 + CD30/412
Dilution:
Flow Cytometry 5 - 10 ul/million cells in 0.1ml, Immunohistochemistry-Paraffin 1:100-1:200, Immunofluorescence 1:50 - 1:100
Classification:
Monoclonal
Form:
Supernatant
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
CD30, CD30 antigen, CD30KI-1, CD30L receptor, cytokine receptor CD30, D1S166EKi-1, Ki-1 antigen, Lymphocyte activation antigen CD30, tumor necrosis factor receptor superfamily member 8, tumor necrosis factor receptor superfamily, member 8
Gene Symbols:
TNFRSF8
Isotype:
IgG
Purification Method:
Tissue culture supernatant
Test Specificity:
Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkins disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
Antigen: CD30/TNFRSF8
Concentration: 0.2mg/mL
Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Apoptosis, Cell Cycle and Replication, Embryonic Stem Cell Markers, Immunology, Stem Cell Markers
Formulation: No buffer with 0.05% Sodium Azide
Gene ID (Entrez): 943
Immunogen: Co cell line established from a patient with Hodgkin's disease of T-cell lineage (Ber-H2); human CD30 recombinant protein (CD30/412)
Primary or Secondary: Primary
Content And Storage: Store at 4C.
Molecular Weight of Antigen: __
Clone: Ber-H2 + CD30/412
Dilution: Flow Cytometry 5 - 10 ul/million cells in 0.1ml, Immunohistochemistry-Paraffin 1:100-1:200, Immunofluorescence 1:50 - 1:100
Classification: Monoclonal
Form: Supernatant
Regulatory Status: RUO
Target Species: Human
Gene Alias: CD30, CD30 antigen, CD30KI-1, CD30L receptor, cytokine receptor CD30, D1S166EKi-1, Ki-1 antigen, Lymphocyte activation antigen CD30, tumor necrosis factor receptor superfamily member 8, tumor necrosis factor receptor superfamily, member 8
Gene Symbols: TNFRSF8
Isotype: IgG
Purification Method: Tissue culture supernatant
Test Specificity: Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkins disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
Antigen:
CD30/TNFRSF8
Concentration:
0.2mg/mL
Applications:
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Apoptosis, Cell Cycle and Replication, Embryonic Stem Cell Markers, Immunology, Stem Cell Markers
Formulation:
No buffer with 0.05% Sodium Azide
Gene ID (Entrez):
943
Immunogen:
Co cell line established from a patient with Hodgkin's disease of T-cell lineage (Ber-H2); human CD30 recombinant protein (CD30/412)
Primary or Secondary:
Primary
Content And Storage:
Store at 4C.
Molecular Weight of Antigen:
__
Clone:
Ber-H2 + CD30/412
Dilution:
Flow Cytometry 5 - 10 ul/million cells in 0.1ml, Immunohistochemistry-Paraffin 1:100-1:200, Immunofluorescence 1:50 - 1:100
Classification:
Monoclonal
Form:
Supernatant
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
CD30, CD30 antigen, CD30KI-1, CD30L receptor, cytokine receptor CD30, D1S166EKi-1, Ki-1 antigen, Lymphocyte activation antigen CD30, tumor necrosis factor receptor superfamily member 8, tumor necrosis factor receptor superfamily, member 8
Gene Symbols:
TNFRSF8
Isotype:
IgG
Purification Method:
Tissue culture supernatant
Test Specificity:
Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkins disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
Antigen: CD30/TNFRSF8
Concentration: 0.2mg/mL
Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Apoptosis, Cell Cycle and Replication, Embryonic Stem Cell Markers, Immunology, Stem Cell Markers
Formulation: No buffer with 0.05% Sodium Azide
Gene ID (Entrez): 943
Immunogen: Co cell line established from a patient with Hodgkin s disease of T-cell lineage
Primary or Secondary: Primary
Content And Storage: Store at 4C.
Molecular Weight of Antigen: __
Clone: Ber-H2
Dilution: Flow Cytometry 5 - 10 ul/million cells in 0.1ml, Immunohistochemistry, Immunohistochemistry-Paraffin 1:50 - 1:100, Immunofluorescence 1:50 - 1:100
Classification: Monoclonal
Form: Supernatant
Regulatory Status: RUO
Target Species: Human
Gene Alias: CD30, CD30 antigen, CD30KI-1, CD30L receptor, cytokine receptor CD30, D1S166EKi-1, Ki-1 antigen, Lymphocyte activation antigen CD30, tumor necrosis factor receptor superfamily member 8, tumor necrosis factor receptor superfamily, member 8
Gene Symbols: TNFRSF8
Isotype: IgG1 κ
Purification Method: Tissue culture supernatant
Test Specificity: Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. Its epitope is located between aa112-412. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
Antigen:
CD30/TNFRSF8
Concentration:
0.2mg/mL
Applications:
Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Apoptosis, Cell Cycle and Replication, Embryonic Stem Cell Markers, Immunology, Stem Cell Markers
Formulation:
No buffer with 0.05% Sodium Azide
Gene ID (Entrez):
943
Immunogen:
Co cell line established from a patient with Hodgkin s disease of T-cell lineage
Primary or Secondary:
Primary
Content And Storage:
Store at 4C.
Molecular Weight of Antigen:
__
Clone:
Ber-H2
Dilution:
Flow Cytometry 5 - 10 ul/million cells in 0.1ml, Immunohistochemistry, Immunohistochemistry-Paraffin 1:50 - 1:100, Immunofluorescence 1:50 - 1:100
Classification:
Monoclonal
Form:
Supernatant
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
CD30, CD30 antigen, CD30KI-1, CD30L receptor, cytokine receptor CD30, D1S166EKi-1, Ki-1 antigen, Lymphocyte activation antigen CD30, tumor necrosis factor receptor superfamily member 8, tumor necrosis factor receptor superfamily, member 8
Gene Symbols:
TNFRSF8
Isotype:
IgG1 κ
Purification Method:
Tissue culture supernatant
Test Specificity:
Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. Its epitope is located between aa112-412. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).