7069643
Desmin Monoclonal Antibody (DE-U-10), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
Desmin
Concentration
0.5 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Alias
CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
Gene Symbols
DES
Primary or Secondary
Primary
Content And Storage
4° C
Gene
DES
Clone
DE-U-10
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Bovine, Chicken, Feline, Goat, Hamster, Human, Mouse, Ovine, Porcine, Rabbit, Rat
Gene Accession No.
O62654, P02540, P02542, P17661, P31001, P48675
Gene ID (Entrez)
100328890, 100764990, 101097010, 101117308, 102180712, 13346, 1674, 280765, 395906, 396725, 64362
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Product Type
Antibody
Related Products
Description
- Description: The monoclonal antibody DE-U-10 recognizes desmin
- Desmin is the protein subunit of class-III intermediate filaments
- Desmin is found predomitly in skeletal, cardiac, and smooth muscle
- Desmin plays a role in muscle cell development and differentiation, muscle cell architecture and structure, and mitochondrial function
- Desmin forms scaffolds around the Z-disk of sarcomeres in muscle cells
- Desmin knockout mice exhibit defects in skeletal, smooth, and cardiac muscle and have impaired mitochondrial function
- Mutations in Desmin result in conditions such as desmin-related myopathy (DRM), cardiomyopathy dilated type 1I (CMD1I), and neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome)
- The DE-U-10 antibody recognizes human, mouse, rat, feline, bovine, goat, hamster, sheep, porcine, rabbit, and chicken desmin
- The DE-U-10 antibody will also label tumors derived from muscle tissue, such as leiomyomas and rhabdomyosarcomas
- Applications Reported: This DE-U-10 antibody has been reported for use in western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, and immunocytochemistry
- Applications Tested: This DE-U-10 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using either low or high pH antigen retrieval and can be used at less than or equal to 5 μg/mL
- Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle)
- Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation
- In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk
- The expression pattern of desmin in smooth muscle is much more heterogenous
- Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e
- rhabdomyosarcomas and leiomyosarcomas
- Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
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Antigen: Desmin
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
Gene Symbols: DES
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: DES
Clone: DE-U-10
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Bovine, Chicken, Feline, Goat, Hamster, Human, Mouse, Ovine, Porcine, Rabbit, Rat
Gene Accession No.: O62654, P02540, P02542, P17661, P31001, P48675
Gene ID (Entrez): 100328890, 100764990, 101097010, 101117308, 102180712, 13346, 1674, 280765, 395906, 396725, 64362
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
Desmin
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
Gene Symbols:
DES
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
DES
Clone:
DE-U-10
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Bovine, Chicken, Feline, Goat, Hamster, Human, Mouse, Ovine, Porcine, Rabbit, Rat
Gene Accession No.:
O62654, P02540, P02542, P17661, P31001, P48675
Gene ID (Entrez):
100328890, 100764990, 101097010, 101117308, 102180712, 13346, 1674, 280765, 395906, 396725, 64362
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: APP (Amyloid Precursor Protein)
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid A4; Amyloid b precursor protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; Amyloid β precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
Gene Symbols: APP
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: APP
Clone: 22C11
Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Human, Mouse, Rat
Gene Accession No.: P05067, P08592, P12023
Gene ID (Entrez): 11820, 351, 54226
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
APP (Amyloid Precursor Protein)
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid A4; Amyloid b precursor protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; Amyloid β precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
Gene Symbols:
APP
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
APP
Clone:
22C11
Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Human, Mouse, Rat
Gene Accession No.:
P05067, P08592, P12023
Gene ID (Entrez):
11820, 351, 54226
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: Collagen X
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: Col10; COL10A1; Col10a-1; Collagen alpha-1(X) chain; collagen type X alpha 1 chain; collagen X, alpha-1 polypeptide; collagen, type X, alpha 1; collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia); pro alpha 1; procollagen, type X, alpha 1; Schmid metaphyseal chondrodysplasia; type X collagen; type X collagen, alpha 1
Gene Symbols: COL10A1
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: COL10A1
Clone: X53
Applications: ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Canine, Guinea Pig, Human, Mouse, Porcine, Rat
Gene Accession No.: Q03692, Q05306
Gene ID (Entrez): 100856711, 106026924, 12813, 1300, 25681, 448809
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
Collagen X
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
Col10; COL10A1; Col10a-1; Collagen alpha-1(X) chain; collagen type X alpha 1 chain; collagen X, alpha-1 polypeptide; collagen, type X, alpha 1; collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia); pro alpha 1; procollagen, type X, alpha 1; Schmid metaphyseal chondrodysplasia; type X collagen; type X collagen, alpha 1
Gene Symbols:
COL10A1
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
COL10A1
Clone:
X53
Applications:
ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Canine, Guinea Pig, Human, Mouse, Porcine, Rat
Gene Accession No.:
Q03692, Q05306
Gene ID (Entrez):
100856711, 106026924, 12813, 1300, 25681, 448809
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: ZO-1
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Gene Symbols: TJP1
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: TJP1
Clone: R26.4C
Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Conjugate: Unconjugated
Host Species: Rat
Target Species: Canine, Mouse, Rat
Gene Accession No.: O97758, P39447
Gene ID (Entrez): 21872, 292994, 403752
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
ZO-1
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Gene Symbols:
TJP1
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
TJP1
Clone:
R26.4C
Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Conjugate:
Unconjugated
Host Species:
Rat
Target Species:
Canine, Mouse, Rat
Gene Accession No.:
O97758, P39447
Gene ID (Entrez):
21872, 292994, 403752
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Product Type:
Antibody