7092801
Stat6 (pY641) Mouse anti-Human, PE, Clone: 18/P-STAT6, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Stat6 (pY641)
Applications
Flow Cytometry
Conjugate
PE
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG2a
Purification Method
Affinity Purified
Description
Signal transducer and activator of transcription 6; IL-4 Stat
Clone
18/P-STAT6
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Phosphorylated Human Stat6 (pY641)
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- Interleukin-4 (IL-4), a major immunoregulatory cytokine, is secreted by activated T lymphocytes, basophils, and mast cells and plays an important role in modulating T helper cell lineage development
- It induces specific gene expression via the tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641)
- Stat6, a member of the s ignal t ransducers and a ctivators of transcription protein family, mediates signals for IL-4 and, possibly, IL-13
- While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta
- Following cytokine receptor ligation, Jak kinases are activated and phosphorylate the cytoplasmic tails of the oligomerized receptors
- The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain
- Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP
- Thus, Stat6 mediates the IL-4 signal and is essential for the proper development of adaptive immunity.
Compare Similar Items
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Antigen: Stat6 (pY641)
Applications: Flow Cytometry
Conjugate: PE
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype: IgG2a
Purification Method: Affinity Purified
Description: Signal transducer and activator of transcription 6; IL-4 Stat
Clone: 18/P-STAT6
Classification: Monoclonal
Host Species: Mouse
Target Species: Human
Immunogen: Phosphorylated Human Stat6 (pY641)
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
Stat6 (pY641)
Applications:
Flow Cytometry
Conjugate:
PE
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype:
IgG2a
Purification Method:
Affinity Purified
Description:
Signal transducer and activator of transcription 6; IL-4 Stat
Clone:
18/P-STAT6
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Human
Immunogen:
Phosphorylated Human Stat6 (pY641)
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: T- and B-Cell Activation Antigen
Applications: Flow Cytometry
Conjugate: FITC
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Isotype: IgM κ
Purification Method: Affinity Purified
Description: GL7
Clone: GL7
Classification: Monoclonal
Host Species: Rat
Target Species: Mouse
Immunogen: In vitro-activated T-cell-depleted CBA/Ca mouse splenocytes
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
T- and B-Cell Activation Antigen
Applications:
Flow Cytometry
Conjugate:
FITC
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Isotype:
IgM κ
Purification Method:
Affinity Purified
Description:
GL7
Clone:
GL7
Classification:
Monoclonal
Host Species:
Rat
Target Species:
Mouse
Immunogen:
In vitro-activated T-cell-depleted CBA/Ca mouse splenocytes
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: T- and B-Cell Activation Antigen
Applications: Flow Cytometry
Conjugate: FITC
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Isotype: IgM κ
Purification Method: Affinity Purified
Description: GL7
Clone: GL7
Classification: Monoclonal
Host Species: Rat
Target Species: Mouse
Immunogen: In vitro-activated T-cell-depleted CBA/Ca mouse splenocytes
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
T- and B-Cell Activation Antigen
Applications:
Flow Cytometry
Conjugate:
FITC
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Isotype:
IgM κ
Purification Method:
Affinity Purified
Description:
GL7
Clone:
GL7
Classification:
Monoclonal
Host Species:
Rat
Target Species:
Mouse
Immunogen:
In vitro-activated T-cell-depleted CBA/Ca mouse splenocytes
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: __
Applications: Flow Cytometry
Conjugate: APC
Regulatory Status: RUO
Formulation: __
Isotype: __
Purification Method: Affinity Purified
Description: __
Clone: H57-597
Classification: Monoclonal
Host Species: Hamster
Target Species: Mouse
Immunogen: TCR affinity-purified from mouse T-cell hybridoma DO-11.10
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
__
Applications:
Flow Cytometry
Conjugate:
APC
Regulatory Status:
RUO
Formulation:
__
Isotype:
__
Purification Method:
Affinity Purified
Description:
__
Clone:
H57-597
Classification:
Monoclonal
Host Species:
Hamster
Target Species:
Mouse
Immunogen:
TCR affinity-purified from mouse T-cell hybridoma DO-11.10
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.