7162920
NKp46 (CD335), Mouse anti-Human, Clone: 461-G1, Millipore Sigma™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
NKp46 (CD335)
Applications
ELISA, Flow Cytometry
Conjugate
Unconjugated
Host Species
Mouse
Research Discipline
Inflammation & Immunology
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez)
NP_001138929
Immunogen
Human IgG1 Fc-fused to a recombinant fragment corresponding to the first 100 amino acids from the extracellular domain of human NKp46.
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Clone
461-G1
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Human
Gene Alias
Natural cytotoxicity triggering receptor 1;Lymphocyte antigen 94 homolog;NK cell-activating receptor;Natural killer cell p46-related protein;NK-p46;hNKp46;CD335
Gene Symbols
NCR1;LY94
Isotype
IgG1 κ
Purification Method
Protein G purified
Test Specificity
Clone 461-G1 specifically recognizes whole human NKp46 and NKp46-D1, but does not recognize NKp46-D2. It targets an epitope with in the first 100 amino acids from the extracellular domain.
Description
- Anti-NKp46 (CD335), clone 461-G1, Cat
- No
- MABF2059, is a mouse monoclonal antibody that detects Natural cytotoxicity triggering receptor 1 and has been tested for use in ELISA and Flow Cytometry
- Natural cytotoxicity triggering receptor 1 (UniProt: O76036; also known as Lymphocyte antigen 94 homolog, NK cell-activating receptor, Natural killer cell p46-related protein, NK-p46, NKp46, hNKp46, CD335) is encoded by the NCR1 (also known as LY94) gene (Gene ID: 9437) in human
- NK-p46 is a single-pass type I membrane protein that belongs to the natural cytotoxicity receptor (NCR) family and serves as a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis and elimination of virus-infected cells
- It is considered as a primary activating receptor mediating NK cell antiviral function
- It is involved in the functional recognition of viral HA and hemagglutinin-neuraminidases
- NKp46 is shown to be predominantly expressed in the nasal lavage of patients infected with respiratory viruses, but not in normal healthy subjects
- Following the initiation of an NK-target cell interaction, NKp46 is reported to cluster at the cell membrane, specifically at the immune synapse where it mediates cytoskeletal rearrangement and cellular polarization
- Human NK-p46 is synthesized with a signal peptide of 21 amino acids, which is subsequently cleaved off
- The mature form has an extracellular domain (aa 22-258), a helical domain (aa 259-279), and a cytoplasmic domain (aa 280-304)
- It also has two Ig-like domains (aa 34-118 and 129-211) termed as D1 and D2
- Five different isoforms of NKp46 have been described that are produced by alternative splicing
- (Ref.: Shemer-Avni, Y., et al., (2017)
- Front
- Immunol
- 8 (Article 161); 1-10).
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Antigen: NKp46 (CD335)
Applications: ELISA, Flow Cytometry
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Inflammation & Immunology
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_001138929
Immunogen: Human IgG1 Fc-fused to a recombinant fragment corresponding to the first 100 amino acids from the extracellular domain of human NKp46.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Clone: 461-G1
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: Natural cytotoxicity triggering receptor 1;Lymphocyte antigen 94 homolog;NK cell-activating receptor;Natural killer cell p46-related protein;NK-p46;hNKp46;CD335
Gene Symbols: NCR1;LY94
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone 461-G1 specifically recognizes whole human NKp46 and NKp46-D1, but does not recognize NKp46-D2. It targets an epitope with in the first 100 amino acids from the extracellular domain.
Antigen:
NKp46 (CD335)
Applications:
ELISA, Flow Cytometry
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Inflammation & Immunology
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_001138929
Immunogen:
Human IgG1 Fc-fused to a recombinant fragment corresponding to the first 100 amino acids from the extracellular domain of human NKp46.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Clone:
461-G1
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
Natural cytotoxicity triggering receptor 1;Lymphocyte antigen 94 homolog;NK cell-activating receptor;Natural killer cell p46-related protein;NK-p46;hNKp46;CD335
Gene Symbols:
NCR1;LY94
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone 461-G1 specifically recognizes whole human NKp46 and NKp46-D1, but does not recognize NKp46-D2. It targets an epitope with in the first 100 amino acids from the extracellular domain.
Antigen: CD11b/CD18
Applications: Dot Blot, Flow Cytometry, Immunohistochemistry, Inhibition Assays
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Cell Structure
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_000623
Immunogen: GST-tagged recombinant fragment corresponding to 211 amino acids from the N-terminal half of human CD11bA.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Clone: mAb107
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human, Non-human Primate
Gene Alias: Integrin alpha-M/ITGB2;CR3
Gene Symbols: ITGAM;CD11B;CR3A
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone mAb 107 detects CD11b/CD18 in human neutrophils. It targets an epitope with in the A domain.
Antigen:
CD11b/CD18
Applications:
Dot Blot, Flow Cytometry, Immunohistochemistry, Inhibition Assays
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Cell Structure
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_000623
Immunogen:
GST-tagged recombinant fragment corresponding to 211 amino acids from the N-terminal half of human CD11bA.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Clone:
mAb107
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human, Non-human Primate
Gene Alias:
Integrin alpha-M/ITGB2;CR3
Gene Symbols:
ITGAM;CD11B;CR3A
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone mAb 107 detects CD11b/CD18 in human neutrophils. It targets an epitope with in the A domain.
Antigen: SLAMF7 (CD319)
Applications: Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Inhibition Assays
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Inflammation & Immunology
Formulation: Purified mouse monoclonal antibody IgG2b in PBS without azide.
Gene ID (Entrez): NP_067004.3
Immunogen: Recombinant protein fragment corresponding to 204 amino acids from the extracellular domain of human SLAM family member 7 fused with human IgG1 constant region.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Clone: 162
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: SLAM family member 7;CD2 subset 1;CD2-like receptor-activating cytotoxic cells;CRACC;Membrane protein FOAP-12;Novel Ly9;Protein 19A;CD319
Gene Symbols: SLAMF7;CS1;UNQ576/PRO1138
Isotype: IgG2b κ
Purification Method: Protein G purified
Test Specificity: Clone 162 is a mouse monoclonal antibody that detects SLAM family member 7 (SLAMF7) in human cells. It targets an epitope with in the extracellular domain.
Antigen:
SLAMF7 (CD319)
Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Inhibition Assays
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Inflammation & Immunology
Formulation:
Purified mouse monoclonal antibody IgG2b in PBS without azide.
Gene ID (Entrez):
NP_067004.3
Immunogen:
Recombinant protein fragment corresponding to 204 amino acids from the extracellular domain of human SLAM family member 7 fused with human IgG1 constant region.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Clone:
162
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
SLAM family member 7;CD2 subset 1;CD2-like receptor-activating cytotoxic cells;CRACC;Membrane protein FOAP-12;Novel Ly9;Protein 19A;CD319
Gene Symbols:
SLAMF7;CS1;UNQ576/PRO1138
Isotype:
IgG2b κ
Purification Method:
Protein G purified
Test Specificity:
Clone 162 is a mouse monoclonal antibody that detects SLAM family member 7 (SLAMF7) in human cells. It targets an epitope with in the extracellular domain.
Antigen: FcRH5
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Inflammation & Immunology
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_112571.2
Immunogen: Full-length FcRH5 expression plasmid followed by a boost with 293T cells transfected with FcRH5 plasmid.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Clone: F56
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: Fc receptor-like protein 5;FcR-like protein 5;FcRL5;BXMAS1;Fc receptor homolog 5;Immune receptor translocation-associated protein 2;IRTA2;CD307e
Gene Symbols: FCRL5;FCRH5;IRTA2;UNQ503/PRO820
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone F56 detects human Fc receptor-like protein 5. It targets an epitope with in the extracellular domain.
Antigen:
FcRH5
Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Inflammation & Immunology
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_112571.2
Immunogen:
Full-length FcRH5 expression plasmid followed by a boost with 293T cells transfected with FcRH5 plasmid.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Clone:
F56
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
Fc receptor-like protein 5;FcR-like protein 5;FcRL5;BXMAS1;Fc receptor homolog 5;Immune receptor translocation-associated protein 2;IRTA2;CD307e
Gene Symbols:
FCRL5;FCRH5;IRTA2;UNQ503/PRO820
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone F56 detects human Fc receptor-like protein 5. It targets an epitope with in the extracellular domain.