7162950
ErbB4, Rabbit anti-Mouse, Clone: mab10, Millipore Sigma™
Rabbit Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
ErbB4
Dilution
Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution from a representative lot detected ErbB4 in mouse embryo tissue sections.Western Blotting Analysis: A representative lot detected ErbB4 in Western Blotting applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).ELISA Analysis: A representative lot detected ErbB4 in ELISA applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).Immunohistochemistry Analysis: A representative lot detected ErbB4 in Immunohistochemistry applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).Immunoprecipitation Analysis: A representative lot immunoprecipitated ErbB4 in Immunoprecipitation applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Mouse
Gene Alias
Receptor tyrosine-protein kinase erbB-4;Proto-oncogene-like protein c-ErbB-4
Gene Symbols
Erbb4;Mer4
Isotype
IgG
Purification Method
Protein G purified
Test Specificity
Clone mAB10 is a rabbit monoclonal antibody that detects mouse Receptor tyrosine-protein kinase erbB-4. It targets an epitope with in the C-terminal region.
Clone
mab10
Applications
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Research Discipline
Neuroscience
Formulation
Purified rabbit monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez)
NP_034284.1
Immunogen
GST-tagged recombinant protein corresponding to 204 amino acids from the C-terminal region of murine Receptor tyrosine-protein kinase erbB-4.
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Description
- Anti-ErbB4, clone mAB10, Cat
- No
- MABN2484, is a highly specific rabbit monoclonal antibody that targets Receptor tyrosine-protein kinase ErbB-4 and has been tested for use in ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, and Western Blotting
- Receptor tyrosine-protein kinase erbB-4 (UniProt: Q61527; also known as EC: 2.7.10.1, Proto-oncogene-like protein c-ErbB-4) is encoded by the Erbb4 (also known as Mer4) gene (Gene ID: 13869) in murine species
- ErbB-4 is a single-pass type I membrane protein of the EGF receptor family that plays an essential role as cell surface receptor for neuregulins (NRG) and EGF family members
- ErbB-4 is monomeric in the absence of bound ligand and it homo- or heterodimerizes with another ERBB family member upon ligand binding
- ErbB-4 is autophosphorylated on tyrosine residues in response to ligand binding that triggers receptor dimerization and autophosphorylation at specific tyrosine residues, which then serve as binding sites for scaffold proteins and effectors
- ErbB-4 is reported to regulate the development of the heart, the central nervous system, and the mammary gland
- It is shown to be involved in gene transcription, cell proliferation, differentiation, migration, and apoptosis
- It is expressed in the developing and adult cerebral cortex, and represents the major NRG receptor in central neurons and regulates a diverse array of neuronal processes, including migration, differentiation, neurotransmission, and synaptic plasticity
- NRG-1 and ErbB-4 are essentials of a signaling pathway that is critical for the proper development of inhibitory cortical and hippocampal circuits
- ErbB-4 expression is reported to be restricted to GABAergic neurons in the cerebral cortex where it plays a role in regulating GABAergic synaptic development and interneuron migration
- ErbB-4 is synthesized with a signal peptide (aa 1-25), which is cleaved off in the mature form
- The mature form has an extracellular domain (aa 26-652), a short transmembrane domain (aa 653-673), and a long cytoplasmic tail (aa 674-1308)
- Its protein kinase domain is localized in the cytoplasmic tail (aa 718-985)
- Three isoforms of ErbB-4 have been described that are produced by alternative splicing.
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Antigen: ErbB4
Dilution: Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution from a representative lot detected ErbB4 in mouse embryo tissue sections.Western Blotting Analysis: A representative lot detected ErbB4 in Western Blotting applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).ELISA Analysis: A representative lot detected ErbB4 in ELISA applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).Immunohistochemistry Analysis: A representative lot detected ErbB4 in Immunohistochemistry applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).Immunoprecipitation Analysis: A representative lot immunoprecipitated ErbB4 in Immunoprecipitation applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Alias: Receptor tyrosine-protein kinase erbB-4;Proto-oncogene-like protein c-ErbB-4
Gene Symbols: Erbb4;Mer4
Isotype: IgG
Purification Method: Protein G purified
Test Specificity: Clone mAB10 is a rabbit monoclonal antibody that detects mouse Receptor tyrosine-protein kinase erbB-4. It targets an epitope with in the C-terminal region.
Clone: mab10
Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Research Discipline: Neuroscience
Formulation: Purified rabbit monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_034284.1
Immunogen: GST-tagged recombinant protein corresponding to 204 amino acids from the C-terminal region of murine Receptor tyrosine-protein kinase erbB-4.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
ErbB4
Dilution:
Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution from a representative lot detected ErbB4 in mouse embryo tissue sections.Western Blotting Analysis: A representative lot detected ErbB4 in Western Blotting applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).ELISA Analysis: A representative lot detected ErbB4 in ELISA applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).Immunohistochemistry Analysis: A representative lot detected ErbB4 in Immunohistochemistry applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).Immunoprecipitation Analysis: A representative lot immunoprecipitated ErbB4 in Immunoprecipitation applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Alias:
Receptor tyrosine-protein kinase erbB-4;Proto-oncogene-like protein c-ErbB-4
Gene Symbols:
Erbb4;Mer4
Isotype:
IgG
Purification Method:
Protein G purified
Test Specificity:
Clone mAB10 is a rabbit monoclonal antibody that detects mouse Receptor tyrosine-protein kinase erbB-4. It targets an epitope with in the C-terminal region.
Clone:
mab10
Applications:
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Research Discipline:
Neuroscience
Formulation:
Purified rabbit monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_034284.1
Immunogen:
GST-tagged recombinant protein corresponding to 204 amino acids from the C-terminal region of murine Receptor tyrosine-protein kinase erbB-4.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: Cdc42
Dilution: Western Blotting Analysis: A representative lot detected Cdc42 in Western Blotting applications (Sullivan, C.S., et. al. (2016). J Biol Chem. 291(51):26262-26272; Wu, H., et. al. (2010). Mol Cell Biol. 30(21):5207-17).Immunocytochemistry Analysis: A representative lot detected Cdc42 in Immunocytochemistry applications (Wu, H., et. al. (2010). Mol Cell Biol. 30(21):5207-17).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse, Human, Yeast
Gene Alias: Cell division control protein 42;Suppressor of RHO3 protein 2
Gene Symbols: CDC42;SRO2;TLR229C;L8083.13
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone 28-10 specifically detects Cell division control protein 42 (Cdc42).
Clone: 28-10
Applications: Immunocytochemistry, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Neuroscience
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_013330
Immunogen: GST-tagged full-length recombinant yeast Cdc42.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
Cdc42
Dilution:
Western Blotting Analysis: A representative lot detected Cdc42 in Western Blotting applications (Sullivan, C.S., et. al. (2016). J Biol Chem. 291(51):26262-26272; Wu, H., et. al. (2010). Mol Cell Biol. 30(21):5207-17).Immunocytochemistry Analysis: A representative lot detected Cdc42 in Immunocytochemistry applications (Wu, H., et. al. (2010). Mol Cell Biol. 30(21):5207-17).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse, Human, Yeast
Gene Alias:
Cell division control protein 42;Suppressor of RHO3 protein 2
Gene Symbols:
CDC42;SRO2;TLR229C;L8083.13
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone 28-10 specifically detects Cell division control protein 42 (Cdc42).
Clone:
28-10
Applications:
Immunocytochemistry, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Neuroscience
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_013330
Immunogen:
GST-tagged full-length recombinant yeast Cdc42.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: Cdc42
Dilution: Western Blotting Analysis: A representative lot detected Cdc42 in Western Blotting applications (Sullivan, C.S., et. al. (2016). J Biol Chem. 291(51):26262-26272; Wu, H., et. al. (2010). Mol Cell Biol. 30(21):5207-17).Immunocytochemistry Analysis: A representative lot detected Cdc42 in Immunocytochemistry applications (Wu, H., et. al. (2010). Mol Cell Biol. 30(21):5207-17).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse, Human, Yeast
Gene Alias: Cell division control protein 42;Suppressor of RHO3 protein 2
Gene Symbols: CDC42;SRO2;TLR229C;L8083.13
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone 28-10 specifically detects Cell division control protein 42 (Cdc42).
Clone: 28-10
Applications: Immunocytochemistry, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Neuroscience
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_013330
Immunogen: GST-tagged full-length recombinant yeast Cdc42.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
Cdc42
Dilution:
Western Blotting Analysis: A representative lot detected Cdc42 in Western Blotting applications (Sullivan, C.S., et. al. (2016). J Biol Chem. 291(51):26262-26272; Wu, H., et. al. (2010). Mol Cell Biol. 30(21):5207-17).Immunocytochemistry Analysis: A representative lot detected Cdc42 in Immunocytochemistry applications (Wu, H., et. al. (2010). Mol Cell Biol. 30(21):5207-17).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse, Human, Yeast
Gene Alias:
Cell division control protein 42;Suppressor of RHO3 protein 2
Gene Symbols:
CDC42;SRO2;TLR229C;L8083.13
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone 28-10 specifically detects Cell division control protein 42 (Cdc42).
Clone:
28-10
Applications:
Immunocytochemistry, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Neuroscience
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_013330
Immunogen:
GST-tagged full-length recombinant yeast Cdc42.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: VMAT1
Dilution: __
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Rat, Mouse
Gene Alias: Chromaffin granule amine transporter;Solute carrier family 18 member 1;Vesicular amine transporter 1;VAT1
Gene Symbols: Scl18a1;Vmat1
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone N440/21 specifically detects Vesicular monoamine transporter 1 (VMAT1) and does not show reactivity with VMAT2. It targets an epitope with in 93 amino acids from the N-terminal first lumenal region.
Clone: N440/21
Applications: Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Neuroscience
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% sodium azide, pH7.4 with 0.05% sodium azide.
Gene ID (Entrez): NP_694694.1
Immunogen: Recombinant fragment corresponding to 93 amino acids from the N-terminal first lumenal region of murine Vesicular amine transporter 1 (VMAT1).
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
VMAT1
Dilution:
__
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Rat, Mouse
Gene Alias:
Chromaffin granule amine transporter;Solute carrier family 18 member 1;Vesicular amine transporter 1;VAT1
Gene Symbols:
Scl18a1;Vmat1
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone N440/21 specifically detects Vesicular monoamine transporter 1 (VMAT1) and does not show reactivity with VMAT2. It targets an epitope with in 93 amino acids from the N-terminal first lumenal region.
Clone:
N440/21
Applications:
Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Neuroscience
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% sodium azide, pH7.4 with 0.05% sodium azide.
Gene ID (Entrez):
NP_694694.1
Immunogen:
Recombinant fragment corresponding to 93 amino acids from the N-terminal first lumenal region of murine Vesicular amine transporter 1 (VMAT1).
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.