7162955
MULT1, Rat anti-Mouse, Clone: 1D6, Millipore Sigma™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
MULT1
Dilution
Immunocytochemistry Analysis: A representative lot detected MULT1 in Immunocytochemistry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).Flow Cytometry Analysis: A representative lot detected MULT1 in Flow Cytometry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).ELISA Analysis: A representative lot detected MULT1 in ELISA applications (Sheppard, S., et. al. (2017). Nat Commun. 8:13930; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Mouse
Gene Alias
MULT-1;ULBP1;mouse UL16-binding protein-like Transcript 1;NKG2DL;NKG2D ligand
Gene Symbols
Ulbp1
Isotype
IgG2a κ
Purification Method
Protein G purified
Test Specificity
Clone 1D6 is a rat monoclonal antibody that detects UL16-binding protein-like transcript 1 splicing variant in mouse.
Clone
1D6
Applications
ELISA, Flow Cytometry, Immunocytochemistry
Conjugate
Unconjugated
Host Species
Rat
Research Discipline
Signaling
Formulation
Purified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez)
NA
Immunogen
Recombinant fragment corresponding to 186 amino acids from the extracellular domain of murine UL16-binding protein-like transcript 1 splicing variant (MULT-1).
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Description
- Anti-MULT1, clone 1D6, Cat
- No
- MABS1906, is a rat monoclonal antibody that detects UL16-binding protein-like transcript 1 splicing variant and has been tested for use in ELISA, Flow Cytometry, and Immunocytochemistry
- UL16-binding protein-like transcript 1 splicing variant (UniProt: Q330P3; also known as MULT1, MULT-1, ULBP1) is encoded by the Ulbp1 gene in murine species
- MULT-1 is a MHC Class I-like molecule that serves as a high affinity ligand for natural Killer Group 2D (NKG2D) receptor
- It is a type I transmembrane protein that is synthesized with a signal peptide (aa 1-25), which is subsequently cleaved off to generate the mature form
- Its transmembrane domain is localized to amino acids 124 to 146 and its extracellular domain contains an alpha 1 and alpha 2 like domain with two intrachain disulfide bonds
- MULT-1 expression is reported to be low or absent in normal adult tissues, however, under conditions of stress and in tumor cells its levels are elevated
- Many tumor cells are shown to release soluble NKG2D ligands through proteolytic shedding, alternative splicing, or exosome secretion
- In mice MULT-1 is shown to cause NK cell activation and tumor rejection
- Mice subjected to cytomegalovirus (MCMV) infection display strong expression of Ulbp1 (Mult1) gene, but surface expression of MULT-1 is nevertheless completely abolished by the virus
- Fc receptor fcr-1 is reported to down-regulate MULT-1 levels by interfering with surface MULT-1 and causing its subsequent degradation in lysosomes
- This effect of Fcr-1 can be completely abolished by imipramine (Cat
- No
- I0899), which blocks AP2-mediated clathrin pathway
- (Ref.: Lenac, T., et al
- (2006)
- J
- Exp
- Med
- 203(8); 1843 1850; Krmpotic, A., et al
- (2005)
- J
- Exp
- Med
- 201(2): 211-220; Deng, W., et al
- (2015)
- Science
- 348(6230); 136-139).
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Antigen: MULT1
Dilution: Immunocytochemistry Analysis: A representative lot detected MULT1 in Immunocytochemistry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).Flow Cytometry Analysis: A representative lot detected MULT1 in Flow Cytometry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).ELISA Analysis: A representative lot detected MULT1 in ELISA applications (Sheppard, S., et. al. (2017). Nat Commun. 8:13930; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Alias: MULT-1;ULBP1;mouse UL16-binding protein-like Transcript 1;NKG2DL;NKG2D ligand
Gene Symbols: Ulbp1
Isotype: IgG2a κ
Purification Method: Protein G purified
Test Specificity: Clone 1D6 is a rat monoclonal antibody that detects UL16-binding protein-like transcript 1 splicing variant in mouse.
Clone: 1D6
Applications: ELISA, Flow Cytometry, Immunocytochemistry
Conjugate: Unconjugated
Host Species: Rat
Research Discipline: Signaling
Formulation: Purified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NA
Immunogen: Recombinant fragment corresponding to 186 amino acids from the extracellular domain of murine UL16-binding protein-like transcript 1 splicing variant (MULT-1).
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
MULT1
Dilution:
Immunocytochemistry Analysis: A representative lot detected MULT1 in Immunocytochemistry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).Flow Cytometry Analysis: A representative lot detected MULT1 in Flow Cytometry applications (Lenac, T., et. al. (2006). J Exp Med. 203(8):1843-50; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).ELISA Analysis: A representative lot detected MULT1 in ELISA applications (Sheppard, S., et. al. (2017). Nat Commun. 8:13930; Krmpotic, A., et. al. (2005). J Exp Med. 201(2):211-20).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Alias:
MULT-1;ULBP1;mouse UL16-binding protein-like Transcript 1;NKG2DL;NKG2D ligand
Gene Symbols:
Ulbp1
Isotype:
IgG2a κ
Purification Method:
Protein G purified
Test Specificity:
Clone 1D6 is a rat monoclonal antibody that detects UL16-binding protein-like transcript 1 splicing variant in mouse.
Clone:
1D6
Applications:
ELISA, Flow Cytometry, Immunocytochemistry
Conjugate:
Unconjugated
Host Species:
Rat
Research Discipline:
Signaling
Formulation:
Purified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NA
Immunogen:
Recombinant fragment corresponding to 186 amino acids from the extracellular domain of murine UL16-binding protein-like transcript 1 splicing variant (MULT-1).
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: Ketohexokinase Isoform C
Dilution: Western Blotting Analysis: 2μg/mL from a represenative lot detected Ketohexokinase Isoform C in HEK293 cells expressing HA-tagged KHK-C.Western Blotting Analysis: 1μg/mL from a represenative lot detected Ketohexokinase Isoform C in human liver tissue lysate.
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: EC: 2.7.1.3;Hepatic fructokinase;Fructokinase
Gene Symbols: KHK
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone 5F1-3F5 specifically detects isoform C of human ketohexokinase.
Clone: 5F1-3F5
Applications: Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Signaling
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_000212
Immunogen: A full-length human recombinant Ketohexokinase, isoform C.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
Ketohexokinase Isoform C
Dilution:
Western Blotting Analysis: 2μg/mL from a represenative lot detected Ketohexokinase Isoform C in HEK293 cells expressing HA-tagged KHK-C.Western Blotting Analysis: 1μg/mL from a represenative lot detected Ketohexokinase Isoform C in human liver tissue lysate.
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
EC: 2.7.1.3;Hepatic fructokinase;Fructokinase
Gene Symbols:
KHK
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone 5F1-3F5 specifically detects isoform C of human ketohexokinase.
Clone:
5F1-3F5
Applications:
Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Signaling
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_000212
Immunogen:
A full-length human recombinant Ketohexokinase, isoform C.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: Ketohexokinase Isoform C
Dilution: Western Blotting Analysis: 2μg/mL from a represenative lot detected Ketohexokinase Isoform C in HEK293 cells expressing HA-tagged KHK-C.Western Blotting Analysis: 1μg/mL from a represenative lot detected Ketohexokinase Isoform C in human liver tissue lysate.
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: EC: 2.7.1.3;Hepatic fructokinase;Fructokinase
Gene Symbols: KHK
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone 5F1-3F5 specifically detects isoform C of human ketohexokinase.
Clone: 5F1-3F5
Applications: Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Signaling
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_000212
Immunogen: A full-length human recombinant Ketohexokinase, isoform C.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
Ketohexokinase Isoform C
Dilution:
Western Blotting Analysis: 2μg/mL from a represenative lot detected Ketohexokinase Isoform C in HEK293 cells expressing HA-tagged KHK-C.Western Blotting Analysis: 1μg/mL from a represenative lot detected Ketohexokinase Isoform C in human liver tissue lysate.
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
EC: 2.7.1.3;Hepatic fructokinase;Fructokinase
Gene Symbols:
KHK
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone 5F1-3F5 specifically detects isoform C of human ketohexokinase.
Clone:
5F1-3F5
Applications:
Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Signaling
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_000212
Immunogen:
A full-length human recombinant Ketohexokinase, isoform C.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: carboxypeptidase M
Dilution: Western Blotting Analysis: A representative lot detected carboxypeptidase M in Western Blotting applications (Fujiwara, N., et. al. (2007). Respirology. 12(1):54-62).Immunoprecipitation Analysis: A representative lot immunoprecipitated carboxypeptidase M in Immunoprecipitation applications (Fujiwara, N., et. al. (2007). Respirology. 12(1):54-62).Immunohistochemistry Analysis: A representative lot detected carboxypeptidase M in Immunohistochemistry applications (Fujiwara, N., et. al. (2007). Respirology. 12(1):54-62).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Rat
Gene Alias: CPM;CP-M
Gene Symbols: Cpm
Isotype: IgG2b κ
Purification Method: Protein G purified
Test Specificity: Clone 7F9 specifically detects carboxypeptidase M in rat tissues.
Clone: 7F9
Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Signaling
Formulation: Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_001101568.1
Immunogen: Membrane fraction of E18.5 embryonic rat lung.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
carboxypeptidase M
Dilution:
Western Blotting Analysis: A representative lot detected carboxypeptidase M in Western Blotting applications (Fujiwara, N., et. al. (2007). Respirology. 12(1):54-62).Immunoprecipitation Analysis: A representative lot immunoprecipitated carboxypeptidase M in Immunoprecipitation applications (Fujiwara, N., et. al. (2007). Respirology. 12(1):54-62).Immunohistochemistry Analysis: A representative lot detected carboxypeptidase M in Immunohistochemistry applications (Fujiwara, N., et. al. (2007). Respirology. 12(1):54-62).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Rat
Gene Alias:
CPM;CP-M
Gene Symbols:
Cpm
Isotype:
IgG2b κ
Purification Method:
Protein G purified
Test Specificity:
Clone 7F9 specifically detects carboxypeptidase M in rat tissues.
Clone:
7F9
Applications:
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Signaling
Formulation:
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_001101568.1
Immunogen:
Membrane fraction of E18.5 embryonic rat lung.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.