7182740
Endoglin/CD105, Rabbit anti-Mouse, Clone: MJ7/18, Novus Biologicals™
Rabbit Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Endoglin/CD105
Concentration
1 mg/mL
Applications
Western Blot, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Conjugate
Unconjugated
Host Species
Rabbit
Research Discipline
Cancer, Cell Biology, Cellular Markers, Endothelial Cell Markers, Extracellular Matrix, Hypoxia, Immunology, Mesenchymal Stem Cell Markers, Stem Cell Markers
Formulation
PBS
Gene ID (Entrez)
2022
Immunogen
MJ7/18 was prepared by immunizing rats with inflamed mouse skin tissue. The antibody was selected immunohistologically for reactivity with endothelial cells.
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone
MJ7/18
Dilution
Western Blot, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Mouse
Gene Alias
CD105, CD105 antigen, endoglin, ENDOsler-Rendu-Weber syndrome 1, HHT1FLJ41744, ORW, ORW1
Gene Symbols
ENG
Isotype
IgG κ
Purification Method
Protein A purified
Test Specificity
MJ7/18 binds specifically to mouse Endoglin/CD105. Endoglin/CD105 is a homodimer expressed by vascular endothelial cells. Endoglin/CD105 functions in adhesion and embryonic angiogenesis. Endoglin/CD105 is a major homodimeric glycoprotein of vascular endothelium involved in cell ahesion through integrin/RGD binding and the regulation of angiogenesis. Also acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Endoglin/CD105 is also required for GDF2/BMP9 signaling through SMAD1 in endothelial cells.
Related Products
Description
- Endoglin/CD105 Monoclonal specifically detects Endoglin/CD105 in Mouse samples
- It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation.
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Antigen: Endoglin/CD105
Concentration: 1 mg/mL
Applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Conjugate: Unconjugated
Host Species: Rabbit
Research Discipline: Cancer, Cell Biology, Cellular Markers, Endothelial Cell Markers, Extracellular Matrix, Hypoxia, Immunology, Mesenchymal Stem Cell Markers, Stem Cell Markers
Formulation: PBS
Gene ID (Entrez): 2022
Immunogen: MJ7/18 was prepared by immunizing rats with inflamed mouse skin tissue. The antibody was selected immunohistologically for reactivity with endothelial cells.
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone: MJ7/18
Dilution: Western Blot, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Alias: CD105, CD105 antigen, endoglin, ENDOsler-Rendu-Weber syndrome 1, HHT1FLJ41744, ORW, ORW1
Gene Symbols: ENG
Isotype: IgG κ
Purification Method: Protein A purified
Test Specificity: MJ7/18 binds specifically to mouse Endoglin/CD105. Endoglin/CD105 is a homodimer expressed by vascular endothelial cells. Endoglin/CD105 functions in adhesion and embryonic angiogenesis. Endoglin/CD105 is a major homodimeric glycoprotein of vascular endothelium involved in cell ahesion through integrin/RGD binding and the regulation of angiogenesis. Also acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Endoglin/CD105 is also required for GDF2/BMP9 signaling through SMAD1 in endothelial cells.
Antigen:
Endoglin/CD105
Concentration:
1 mg/mL
Applications:
Western Blot, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Conjugate:
Unconjugated
Host Species:
Rabbit
Research Discipline:
Cancer, Cell Biology, Cellular Markers, Endothelial Cell Markers, Extracellular Matrix, Hypoxia, Immunology, Mesenchymal Stem Cell Markers, Stem Cell Markers
Formulation:
PBS
Gene ID (Entrez):
2022
Immunogen:
MJ7/18 was prepared by immunizing rats with inflamed mouse skin tissue. The antibody was selected immunohistologically for reactivity with endothelial cells.
Primary or Secondary:
Primary
Content And Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone:
MJ7/18
Dilution:
Western Blot, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Alias:
CD105, CD105 antigen, endoglin, ENDOsler-Rendu-Weber syndrome 1, HHT1FLJ41744, ORW, ORW1
Gene Symbols:
ENG
Isotype:
IgG κ
Purification Method:
Protein A purified
Test Specificity:
MJ7/18 binds specifically to mouse Endoglin/CD105. Endoglin/CD105 is a homodimer expressed by vascular endothelial cells. Endoglin/CD105 functions in adhesion and embryonic angiogenesis. Endoglin/CD105 is a major homodimeric glycoprotein of vascular endothelium involved in cell ahesion through integrin/RGD binding and the regulation of angiogenesis. Also acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Endoglin/CD105 is also required for GDF2/BMP9 signaling through SMAD1 in endothelial cells.
Antigen: Integrin beta 7
Concentration: 1 mg/mL
Applications: Flow Cytometry, Immunoprecipitation, Blocking Assay
Conjugate: Unconjugated
Host Species: Rabbit
Research Discipline: Signal Transduction
Formulation: PBS
Gene ID (Entrez): 3695
Immunogen: FIB27 was prepared by immunizing rats with TK1 cells.
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone: FIB27
Dilution: Flow Cytometry, Immunoprecipitation, Block/Neutralize
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human, Mouse
Gene Alias: Gut homing receptor beta subunit, integrin beta 7 subunit, integrin beta-7, integrin, beta 7
Gene Symbols: ITGB7
Isotype: IgG κ
Purification Method: Protein A purified
Test Specificity: FIB27 binds specifically to both human and mouse Integrin beta 7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta 7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.
Antigen:
Integrin beta 7
Concentration:
1 mg/mL
Applications:
Flow Cytometry, Immunoprecipitation, Blocking Assay
Conjugate:
Unconjugated
Host Species:
Rabbit
Research Discipline:
Signal Transduction
Formulation:
PBS
Gene ID (Entrez):
3695
Immunogen:
FIB27 was prepared by immunizing rats with TK1 cells.
Primary or Secondary:
Primary
Content And Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone:
FIB27
Dilution:
Flow Cytometry, Immunoprecipitation, Block/Neutralize
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human, Mouse
Gene Alias:
Gut homing receptor beta subunit, integrin beta 7 subunit, integrin beta-7, integrin, beta 7
Gene Symbols:
ITGB7
Isotype:
IgG κ
Purification Method:
Protein A purified
Test Specificity:
FIB27 binds specifically to both human and mouse Integrin beta 7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta 7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.
Antigen: Integrin beta 7
Concentration: 1 mg/mL
Applications: Flow Cytometry, Immunoprecipitation, Blocking Assay
Conjugate: Unconjugated
Host Species: Rabbit
Research Discipline: Signal Transduction
Formulation: PBS
Gene ID (Entrez): 3695
Immunogen: FIB27 was prepared by immunizing rats with TK1 cells.
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone: FIB27
Dilution: Flow Cytometry, Immunoprecipitation, Block/Neutralize
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human, Mouse
Gene Alias: Gut homing receptor beta subunit, integrin beta 7 subunit, integrin beta-7, integrin, beta 7
Gene Symbols: ITGB7
Isotype: IgG κ
Purification Method: Protein A purified
Test Specificity: FIB27 binds specifically to both human and mouse Integrin beta 7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta 7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.
Antigen:
Integrin beta 7
Concentration:
1 mg/mL
Applications:
Flow Cytometry, Immunoprecipitation, Blocking Assay
Conjugate:
Unconjugated
Host Species:
Rabbit
Research Discipline:
Signal Transduction
Formulation:
PBS
Gene ID (Entrez):
3695
Immunogen:
FIB27 was prepared by immunizing rats with TK1 cells.
Primary or Secondary:
Primary
Content And Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone:
FIB27
Dilution:
Flow Cytometry, Immunoprecipitation, Block/Neutralize
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human, Mouse
Gene Alias:
Gut homing receptor beta subunit, integrin beta 7 subunit, integrin beta-7, integrin, beta 7
Gene Symbols:
ITGB7
Isotype:
IgG κ
Purification Method:
Protein A purified
Test Specificity:
FIB27 binds specifically to both human and mouse Integrin beta 7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta 7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.
Antigen: CD44
Concentration: 1 mg/mL
Applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunofluorescence, Immunoprecipitation, Blocking Assay
Conjugate: Unconjugated
Host Species: Rabbit
Research Discipline: Angiogenesis, Apoptosis, Cancer, Cell Biology, Core ESC Like Genes, Extracellular Matrix, Hematopoietic Stem Cell Markers, Immunology, Mesenchymal Stem Cell Markers, Oncogenes, Phospho Specific, Protein Kinase, Signal Transduction, Stem Cell Markers
Formulation: PBS
Gene ID (Entrez): 960
Immunogen: This antibody was produced by immunizing a Fischer rat with human tonsil lymphocytes (10^7cells intraperitoneally in Freund's complete adjuvant). A boost was given 2 weeks later (intravascularly in saline).
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone: Hermes-1
Dilution: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Block/Neutralize
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human, Mouse, Rat, Bovine, Goat, Primate, Rabbit, Sheep
Gene Alias: CD44 antigen, CD44 molecule (Indian blood group), CD44R, CDw44, cell surface glycoprotein CD44, chondroitin sulfate proteoglycan 8, CSPG8, ECMR-III, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HCELL, hematopoietic cell E- and L-selectin ligand, Heparan sulfate proteoglycan, Hermes antigen, homing function and Indian blood group system, HUTCH-I, Hyaluronate receptor, IN, LHR, MC56, MDU2CD44 antigen (homing function and Indian blood group system), MDU3CDW44, MIC4MGC10468, Pgp1, PGP-1, PGP-I, Phagocytic glycoprotein 1, Phagocytic glycoprotein I
Gene Symbols: CD44
Isotype: IgG κ
Purification Method: Protein A purified
Test Specificity: This antibody is specific for CD44 (gp90 epitope cluster I), which is selectively expressed on normal or transformed lymphoid cells that are able to recognize and bind to high endothelial venules (specialized vessels that mediate lymphocyte exit from the blood into lymphoid organs). Although this antibody was raised against human CD44, it cross-reacts with murine, rat, rabbit, primate, sheep, bovine and goat CD44.
Antigen:
CD44
Concentration:
1 mg/mL
Applications:
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunofluorescence, Immunoprecipitation, Blocking Assay
Conjugate:
Unconjugated
Host Species:
Rabbit
Research Discipline:
Angiogenesis, Apoptosis, Cancer, Cell Biology, Core ESC Like Genes, Extracellular Matrix, Hematopoietic Stem Cell Markers, Immunology, Mesenchymal Stem Cell Markers, Oncogenes, Phospho Specific, Protein Kinase, Signal Transduction, Stem Cell Markers
Formulation:
PBS
Gene ID (Entrez):
960
Immunogen:
This antibody was produced by immunizing a Fischer rat with human tonsil lymphocytes (10^7cells intraperitoneally in Freund's complete adjuvant). A boost was given 2 weeks later (intravascularly in saline).
Primary or Secondary:
Primary
Content And Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone:
Hermes-1
Dilution:
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Block/Neutralize
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human, Mouse, Rat, Bovine, Goat, Primate, Rabbit, Sheep
Gene Alias:
CD44 antigen, CD44 molecule (Indian blood group), CD44R, CDw44, cell surface glycoprotein CD44, chondroitin sulfate proteoglycan 8, CSPG8, ECMR-III, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HCELL, hematopoietic cell E- and L-selectin ligand, Heparan sulfate proteoglycan, Hermes antigen, homing function and Indian blood group system, HUTCH-I, Hyaluronate receptor, IN, LHR, MC56, MDU2CD44 antigen (homing function and Indian blood group system), MDU3CDW44, MIC4MGC10468, Pgp1, PGP-1, PGP-I, Phagocytic glycoprotein 1, Phagocytic glycoprotein I
Gene Symbols:
CD44
Isotype:
IgG κ
Purification Method:
Protein A purified
Test Specificity:
This antibody is specific for CD44 (gp90 epitope cluster I), which is selectively expressed on normal or transformed lymphoid cells that are able to recognize and bind to high endothelial venules (specialized vessels that mediate lymphocyte exit from the blood into lymphoid organs). Although this antibody was raised against human CD44, it cross-reacts with murine, rat, rabbit, primate, sheep, bovine and goat CD44.