7188648
HIF-1 alpha Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
HIF-1 alpha
Applications
ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q16665
Gene ID (Entrez)
3091
Immunogen
This HIF-1 alpha antibody was raised against a synthetic peptide corresponding to the C-terminal region of human HIF-1 alpha.
Primary or Secondary
Primary
Product Type
Antibody
Concentration
Conc. Not Determined
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene Alias
AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; BHLHE78; BOS_11009; Class E basic helix-loop-helix protein 78; HIF1; HIF1 alpha; HIF-1 alpha; hif1a; HIF-1A; hif1a.L; HIF1alpha; hif-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; Hypoxia-inducible factor 1-alpha; hypoxia-inducible factor1alpha; Member of PAS
Gene Symbols
HIF1A
Isotype
IgG
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
HIF1A
Related Products
Description
- HIF1-alpha (HIF1A) is a subunit of HIF1, which is a transcription factor found in mammalian cells cultured under reduced oxygen tension
- HIF-1 is a heterodimer consisting of an alpha and beta subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors
- HIF1 functions as a transcriptional regulator of the adaptive response to hypoxia
- Under hypoxic conditions, HIF-1 activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia
- HIF1-alpha regulates hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis
- Hypoxia which induces p53 protein accumulation, directly interacts with HIF1-alpha and reduces hypoxia-induced expression of HIF1-alpha by promoting MDM2-mediated ubiquitination and proteasomal degradation under hypoxic conditions
- Recent studies suggest that induction of NOX4 by HIF1-alpha contributes to maintain ROS levels after hypoxia and hypoxia-induced proliferation
- In humans, it is located on the q arm of chromosome 14
- The C-terminal of HIF1A binds to p300
- p300/CBP-HIF complexes participate in the induction of hypoxia-responsive genes, including VEGF
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease.
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Antigen: HIF-1 alpha
Applications: ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q16665
Gene ID (Entrez): 3091
Immunogen: This HIF-1 alpha antibody was raised against a synthetic peptide corresponding to the C-terminal region of human HIF-1 alpha.
Primary or Secondary: Primary
Product Type: Antibody
Concentration: Conc. Not Determined
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene Alias: AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; BHLHE78; BOS_11009; Class E basic helix-loop-helix protein 78; HIF1; HIF1 alpha; HIF-1 alpha; hif1a; HIF-1A; hif1a.L; HIF1alpha; hif-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; Hypoxia-inducible factor 1-alpha; hypoxia-inducible factor1alpha; Member of PAS
Gene Symbols: HIF1A
Isotype: IgG
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: HIF1A
Antigen:
HIF-1 alpha
Applications:
ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q16665
Gene ID (Entrez):
3091
Immunogen:
This HIF-1 alpha antibody was raised against a synthetic peptide corresponding to the C-terminal region of human HIF-1 alpha.
Primary or Secondary:
Primary
Product Type:
Antibody
Concentration:
Conc. Not Determined
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene Alias:
AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; BHLHE78; BOS_11009; Class E basic helix-loop-helix protein 78; HIF1; HIF1 alpha; HIF-1 alpha; hif1a; HIF-1A; hif1a.L; HIF1alpha; hif-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; Hypoxia-inducible factor 1-alpha; hypoxia-inducible factor1alpha; Member of PAS
Gene Symbols:
HIF1A
Isotype:
IgG
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
HIF1A
Antigen: FOXO1/FKHR
Applications: Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q12778
Gene ID (Entrez): 2308
Immunogen: This FOXO1/FkHR antibody was raised against a peptide from the C-terminal region of human FOXO1/FkHR.
Primary or Secondary: Primary
Product Type: Antibody
Concentration: Lot-Specific
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias: Afxh; AI876417; FKH1; FKHR; Fkhr1; forkhead box O1; forkhead box O1 a; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O1-A; Forkhead in rhabdomyosarcoma; forkhead protein 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; fox family transcription factor FoxO1a.1; FOX01A; foxhead box protein O1-A; Foxo1; Foxo1a; foxO1a.1; zgc:153388
Gene Symbols: FOXO1
Isotype: IgG
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: FOXO1
Antigen:
FOXO1/FKHR
Applications:
Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q12778
Gene ID (Entrez):
2308
Immunogen:
This FOXO1/FkHR antibody was raised against a peptide from the C-terminal region of human FOXO1/FkHR.
Primary or Secondary:
Primary
Product Type:
Antibody
Concentration:
Lot-Specific
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias:
Afxh; AI876417; FKH1; FKHR; Fkhr1; forkhead box O1; forkhead box O1 a; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O1-A; Forkhead in rhabdomyosarcoma; forkhead protein 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; fox family transcription factor FoxO1a.1; FOX01A; foxhead box protein O1-A; Foxo1; Foxo1a; foxO1a.1; zgc:153388
Gene Symbols:
FOXO1
Isotype:
IgG
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
FOXO1
Antigen: Mi-2
Applications: Immunofluorescence, Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Rat
Target Species: Drosophila
Gene Accession No.: __
Gene ID (Entrez): __
Immunogen: This antibody was raised against a synthetic peptide corresponding to amino acid residues 1641-1662 of Drosophila Mi-2.
Primary or Secondary: Primary
Product Type: Antibody
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias: 9530019N15Rik; AA617397; ATP-dependent helicase CHD4; BC005710; CHD4; CHD-4; chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4; D6Ertd380e; Mi-2; Mi-2 autoantigen; Mi-2 autoantigen 218 kDa protein; Mi-2 beta; MI2B; Mi-2b; Mi-2beta; Mi2-beta; mKIAA4075
Gene Symbols: __
Isotype: IgG2c
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: __
Antigen:
Mi-2
Applications:
Immunofluorescence, Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Rat
Target Species:
Drosophila
Gene Accession No.:
__
Gene ID (Entrez):
__
Immunogen:
This antibody was raised against a synthetic peptide corresponding to amino acid residues 1641-1662 of Drosophila Mi-2.
Primary or Secondary:
Primary
Product Type:
Antibody
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias:
9530019N15Rik; AA617397; ATP-dependent helicase CHD4; BC005710; CHD4; CHD-4; chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4; D6Ertd380e; Mi-2; Mi-2 autoantigen; Mi-2 autoantigen 218 kDa protein; Mi-2 beta; MI2B; Mi-2b; Mi-2beta; Mi2-beta; mKIAA4075
Gene Symbols:
__
Isotype:
IgG2c
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
__
Antigen: Histone H3ac (pan-acetyl)
Applications: __
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: __
Gene ID (Entrez): __
Immunogen: This antibody was raised against a peptide including acetyl-lysines contained in the N-terminal tail of human Histone H3.
Primary or Secondary: Primary
Product Type: Antibody
Concentration: Lot-Specific
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias: __
Gene Symbols: __
Isotype: IgG
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: __
Antigen:
Histone H3ac (pan-acetyl)
Applications:
__
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
__
Gene ID (Entrez):
__
Immunogen:
This antibody was raised against a peptide including acetyl-lysines contained in the N-terminal tail of human Histone H3.
Primary or Secondary:
Primary
Product Type:
Antibody
Concentration:
Lot-Specific
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias:
__
Gene Symbols:
__
Isotype:
IgG
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
__