Tmem119 Monoclonal Antibody (V3RT1GOsz), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Description

• Tmem119 encodes a single-pass type I transmembrane protein which seems to interact with a multitude of micro-RNAs as well as certain transcription factors such as SMAD1, SMAD5 and RUNX2
• Tmem119 has been identified as a surface marker of microglia that can be used to reliably distinguish microglia from infiltrating macrophages
• Microglial cells are phagocytes that are restricted to the brain and involved in clearing up debris and dendrite pruning of neurons
• They display a high functional plasticity, balancing neuroprotective and neurotoxic functions, which is reflected by their distinct physiology in response to changes in their microenvironment
• Microglia are particularly mobile in areas of the brain undergoing restructuring
• Reactive microglia co-express the marker Iba1
• In a pathological context, microglia have been associated with differentiation of pathogenic/inflammatory A1 type astrocytes by secretion of Cq1, IL-1a and TNF when stimulated with LPS, and thought to contribute to the pathology of several neurodegenerative diseases such as Alzheimers, Parkinsons, Chorea Huntingtons disease and Multiple Sclerosis
• The specific function Tmem119 plays on microglial cells remains unclear
• Outside of the neural system, Tmem119 seems to be involved in osteoblast differentiation/ossification.