P2X7/P2RX7 Antibody (Hano43) - BSA Free, Novus Biologicals™
Rat Monoclonal Antibody has been used in 2 publications
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
P2X7/P2RX7
Concentration
1 mg/mL
Applications
Immunocytochemistry, Flow Cytometry, Immunofluorescence
Conjugate
Unconjugated
Host Species
Rat
Target Species
Mouse
Gene Accession No.
Q9Z1M0
Gene ID (Entrez)
5027
Immunogen
A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
Primary or Secondary
Primary
Content And Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Clone
Hano43
Dilution
Flow Cytometry 1:25-1:200, Immunocytochemistry/Immunofluorescence 1:10-1:2000
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Formulation
PBS (pH 7.4) with 0.09% Sodium Azide
Gene Alias
ATP receptor, MGC20089, P2X purinoceptor 7, P2X7P2X7 receptor, P2X7R, P2Z receptor, Purinergic receptor, purinergic receptor P2X, ligand-gated ion channel, 7, purinergic receptor P2X7 variant A
Gene Symbols
P2RX7
Isotype
IgG2b
Purification Method
Protein G purified
Test Specificity
This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
Related Products
Description
- Description P2X7/P2RX7 Monoclonal specifically detects P2X7/P2RX7 in Mouse samples
- It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence.
Compare Similar Items
Show Difference
Antigen: P2X7/P2RX7
Concentration: 1 mg/mL
Applications: Immunocytochemistry, Flow Cytometry, Immunofluorescence
Conjugate: Unconjugated
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q9Z1M0
Gene ID (Entrez): 5027
Immunogen: A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
Primary or Secondary: Primary
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Clone: Hano43
Dilution: Flow Cytometry 1:25-1:200, Immunocytochemistry/Immunofluorescence 1:10-1:2000
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Formulation: PBS (pH 7.4) with 0.09% Sodium Azide
Gene Alias: ATP receptor, MGC20089, P2X purinoceptor 7, P2X7P2X7 receptor, P2X7R, P2Z receptor, Purinergic receptor, purinergic receptor P2X, ligand-gated ion channel, 7, purinergic receptor P2X7 variant A
Gene Symbols: P2RX7
Isotype: IgG2b
Purification Method: Protein G purified
Test Specificity: This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
Antigen: PDE7A
Concentration: __
Applications: Western Blot, Immunoprecipitation
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human, Mouse, Rat
Gene Accession No.: __
Gene ID (Entrez): 5150
Immunogen: Synthetic cyclic peptide (common to all PDE7A variants).
Primary or Secondary: Primary
Content And Storage: __
Clone: __
Dilution: Western Blot 1:500, Immunoprecipitation 1:250
Classification: Polyclonal
Form: __
Regulatory Status: __
Formulation: __
Gene Alias: __
Gene Symbols: PDE7A
Isotype: IgG
Purification Method: __
Test Specificity: PDE7A
Antigen: PIGF
Concentration: LYOPH
Applications: __
Conjugate: Unconjugated
Host Species: Rat
Target Species: Mouse
Gene Accession No.: __
Gene ID (Entrez): 5281
Immunogen: Mouse recombinant PlGF protein.
Primary or Secondary: Primary
Content And Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Clone: RM0010-8F09
Dilution: __
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Formulation: __
Gene Alias: GPI11 homolog, MGC32646, MGC33136, phosphatidylinositol glycan anchor biosynthesis, class F, phosphatidylinositol glycan, class F, phosphatidylinositol-glycan biosynthesis class F protein, PIG-F
Gene Symbols: PIGF
Isotype: IgG2
Purification Method: Protein G purified
Test Specificity: This recognizes mouse PlGF.