7215119
Phospho-Histone H2A.X (Ser139) Recombinant Rabbit Monoclonal Antibody (HisH2AXS139-1E4), PE, Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Phospho-Histone H2A.X (Ser139)
Applications
Flow Cytometry
Conjugate
PE
Host Species
Rabbit
Target Species
Human, Mouse
Gene Accession No.
P16104, P27661
Gene ID (Entrez)
15270, 3014
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho histone H2A.X.
Primary or Secondary
Primary
Content And Storage
4° C
Gene
H2AX
Clone
HisH2AXS139-1E4
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias
AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Gene Symbols
H2AX
Isotype
IgG κ
Purification Method
Protein A/G
Product Type
Antibody
Related Products
Description
- Description Histone H2A.X (H2AX) is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle
- In eukaryotes, DNA double strand breaks (DSBs) have been shown to trigger the phosphorylation of serine 139 at the carboxy terminus of histone H2AX resulting in gamma-H2AX
- The phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs
- The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner
- Structurally, H2A.x contains 143 amino acid residues
- Histone H2A.X is considered a basal histone, being synthesized in G1 as well as in S-phase, and its mRNA contains polyA addition motifs and a polyA tail along with the conserved stem-loop and U7 binding sequences involved in the processing and stability of replication type histone mRNAs
- There are two forms of Histone H2A.X mRNA, one about 1600 bases long and contains polyA; the other about 575 bases long, lacking polyA
- The short form behaves as a replication type histone mRNA, while the longer behaves as a basal type histone mRNA
- Histone H2A.X maps to the 11q23.2-q23.3 region of the human chromosome
- Histone H2A.x contributes to histone-formation and therefore the structure of DNA
- Histone H2A variant H2A.x specifically regulates the interaction of MDC1 (mediator of DNA damage checkpoint protein 1), a DNA repair protein to the sites of DNA damage.
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Antigen: Phospho-Histone H2A.X (Ser139)
Applications: Flow Cytometry
Conjugate: PE
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: P16104, P27661
Gene ID (Entrez): 15270, 3014
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho histone H2A.X.
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: H2AX
Clone: HisH2AXS139-1E4
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias: AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Gene Symbols: H2AX
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-Histone H2A.X (Ser139)
Applications:
Flow Cytometry
Conjugate:
PE
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
P16104, P27661
Gene ID (Entrez):
15270, 3014
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho histone H2A.X.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
H2AX
Clone:
HisH2AXS139-1E4
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Gene Symbols:
H2AX
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody
Antigen: Phospho-S6 Ribosomal Protein (Ser240, Ser244)
Applications: Flow Cytometry
Conjugate: PE
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: P62753, P62754
Gene ID (Entrez): 20104, 6194
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser240/244 of human phospho S6 Ribosomal protein.
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: RPS6
Clone: S6RPS240244-CD10
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias: (Rp)S6; 40S ribosomal protein S6; air[8]; air8; anon-WO02059370.61; CG10944; CG10944-PA; CG10944-PB; Dmel\CG10944; Dmel_CG10944; DS6; hemocytes enlarged; hen; l(1)air[8]; l(1)air8; l(1)hen; LD31286p; lethal(1)aberrant immune response[8]; lethal-(1)-haemocytes enlarged; lethal-aberrant-immune-response-8; M(1)7BC; M(1)7C; minute; minute (1) 7BC; OK/SW-cl.2; OTTHUMP00000021121; OTTHUMP00000021122; Phosphoprotein NP33; pp30; ribosomal protein S6; Rp S6; RP11-513M16.6; RPS6; RpS6-PA; RpS6-PB; RS6; S6; S6 ribosomal protein; S6R; Small ribosomal subunit protein eS6; wu:fa92e06; wu:fb64g06; zgc:92237
Gene Symbols: RPS6
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-S6 Ribosomal Protein (Ser240, Ser244)
Applications:
Flow Cytometry
Conjugate:
PE
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
P62753, P62754
Gene ID (Entrez):
20104, 6194
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser240/244 of human phospho S6 Ribosomal protein.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
RPS6
Clone:
S6RPS240244-CD10
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
(Rp)S6; 40S ribosomal protein S6; air[8]; air8; anon-WO02059370.61; CG10944; CG10944-PA; CG10944-PB; Dmel\CG10944; Dmel_CG10944; DS6; hemocytes enlarged; hen; l(1)air[8]; l(1)air8; l(1)hen; LD31286p; lethal(1)aberrant immune response[8]; lethal-(1)-haemocytes enlarged; lethal-aberrant-immune-response-8; M(1)7BC; M(1)7C; minute; minute (1) 7BC; OK/SW-cl.2; OTTHUMP00000021121; OTTHUMP00000021122; Phosphoprotein NP33; pp30; ribosomal protein S6; Rp S6; RP11-513M16.6; RPS6; RpS6-PA; RpS6-PB; RS6; S6; S6 ribosomal protein; S6R; Small ribosomal subunit protein eS6; wu:fa92e06; wu:fb64g06; zgc:92237
Gene Symbols:
RPS6
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody
Antigen: Phospho-S6 Ribosomal Protein (Ser235, Ser236)
Applications: Flow Cytometry
Conjugate: PE
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: P62753, P62754
Gene ID (Entrez): 20104, 6194
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser235/236 of human phospho S6 Ribosomal Protein.
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: RPS6
Clone: S6S235S236-R3A2
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias: (Rp)S6; 40S ribosomal protein S6; air[8]; air8; anon-WO02059370.61; CG10944; CG10944-PA; CG10944-PB; Dmel\CG10944; Dmel_CG10944; DS6; hemocytes enlarged; hen; l(1)air[8]; l(1)air8; l(1)hen; LD31286p; lethal(1)aberrant immune response[8]; lethal-(1)-haemocytes enlarged; lethal-aberrant-immune-response-8; M(1)7BC; M(1)7C; minute; minute (1) 7BC; OK/SW-cl.2; OTTHUMP00000021121; OTTHUMP00000021122; Phosphoprotein NP33; pp30; ribosomal protein S6; Rp S6; RP11-513M16.6; RPS6; RpS6-PA; RpS6-PB; RS6; S6; S6 ribosomal protein; S6R; Small ribosomal subunit protein eS6; wu:fa92e06; wu:fb64g06; zgc:92237
Gene Symbols: RPS6
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-S6 Ribosomal Protein (Ser235, Ser236)
Applications:
Flow Cytometry
Conjugate:
PE
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
P62753, P62754
Gene ID (Entrez):
20104, 6194
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser235/236 of human phospho S6 Ribosomal Protein.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
RPS6
Clone:
S6S235S236-R3A2
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
(Rp)S6; 40S ribosomal protein S6; air[8]; air8; anon-WO02059370.61; CG10944; CG10944-PA; CG10944-PB; Dmel\CG10944; Dmel_CG10944; DS6; hemocytes enlarged; hen; l(1)air[8]; l(1)air8; l(1)hen; LD31286p; lethal(1)aberrant immune response[8]; lethal-(1)-haemocytes enlarged; lethal-aberrant-immune-response-8; M(1)7BC; M(1)7C; minute; minute (1) 7BC; OK/SW-cl.2; OTTHUMP00000021121; OTTHUMP00000021122; Phosphoprotein NP33; pp30; ribosomal protein S6; Rp S6; RP11-513M16.6; RPS6; RpS6-PA; RpS6-PB; RS6; S6; S6 ribosomal protein; S6R; Small ribosomal subunit protein eS6; wu:fa92e06; wu:fb64g06; zgc:92237
Gene Symbols:
RPS6
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody
Antigen: Phospho-ZAP70/Syk (Tyr319, Tyr352)
Applications: Flow Cytometry
Conjugate: FITC
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: P43403, P43404
Gene ID (Entrez): 22637, 7535
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr319/Tyr352 of human phospho Zap70/Syk.
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark
Gene: ZAP70
Clone: Zap70Y319-A3
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias: 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; ADMIO2; EC 2.7.10.2; FLJ17670; FLJ17679; I79_004087; IMD48; kinase ZAP70; mrtle; mur; Selective T cell defect; Srk; STCD; STD; syk-related protein tyrosine kinase; syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; Tyrosine-protein kinase ZAP-70;TZK; TZK; ZA70; Zap70; ZAP-70; Zeta chain associated protein kinase 70kDa; zeta chain of T cell receptor associated protein kinase; zeta chain of T cell receptor associated protein kinase 70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Gene Symbols: ZAP70
Isotype: IgG κ
Purification Method: Protein A/G
Product Type: Antibody
Antigen:
Phospho-ZAP70/Syk (Tyr319, Tyr352)
Applications:
Flow Cytometry
Conjugate:
FITC
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
P43403, P43404
Gene ID (Entrez):
22637, 7535
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr319/Tyr352 of human phospho Zap70/Syk.
Primary or Secondary:
Primary
Content And Storage:
4° C, store in dark
Gene:
ZAP70
Clone:
Zap70Y319-A3
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; ADMIO2; EC 2.7.10.2; FLJ17670; FLJ17679; I79_004087; IMD48; kinase ZAP70; mrtle; mur; Selective T cell defect; Srk; STCD; STD; syk-related protein tyrosine kinase; syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; Tyrosine-protein kinase ZAP-70;TZK; TZK; ZA70; Zap70; ZAP-70; Zeta chain associated protein kinase 70kDa; zeta chain of T cell receptor associated protein kinase; zeta chain of T cell receptor associated protein kinase 70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Gene Symbols:
ZAP70
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody