7218512

Cytokeratin 18 Monoclonal Antibody (LDK18), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Cytokeratin 18

Concentration

0.5 mg/mL

Conjugate

Unconjugated

Host Species

Mouse

Target Species

Human

Gene Accession No.

P05783

Isotype

IgG1 κ

Purification Method

Affinity chromatography

Product Type

Antibody

Clone

LDK18

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez)

3875

Primary or Secondary

Primary

Content And Storage

4° C

Gene

KRT18

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Description

  • Description: The monoclonal antibody LDK18 recognizes human Cytokeratin 18
  • Cytokeratin 18 is member of the large family of intermediate filaments found within epithelial cells
  • The family of cytokeratins is made up of type I (acidic) and type II (basic) members which form heterodimers by pairing an acidic with a basic member to compose the keratin filament
  • Cytokeratin 18 (type I) is most commonly found associated with cytokeratin 8 (type II)
  • Because many tumors of epithelial origin retain expression of keratin proteins, cytokeratin 18 has been used as a tumor marker to identify both tumors and metastases
  • In addition, cytokeratin 18 has been shown to be expressed in highly proliferative retinal pigment epithelium cells
  • Applications Reported: This LDK18 antibody has been reported for use in western blotting, microscopy, immunohistochemical staining, and immunocytochemistry
  • Applications Tested: This LDK18 antibody has been tested by immmunocytochemistry of MeOH-fixed human cells and can be used at less than or equal to 1 μg/mL
  • It is recommended that the antibody be titrated for optimal performance in the assay of interest
  • Purity: Greater than 90%, as determined by SDS-PAGE
  • Aggregation: Less than 10%, as determined by HPLC
  • Filtration: 0.2 μm post-manufacturing filtered
  • Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8
  • Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18
  • Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas
  • Hepatocellular carcinomas express only cytokeratins 8 and 18
  • Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis
  • Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene
  • Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies
  • The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

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Antigen:
Cytokeratin 18

Concentration:
0.5 mg/mL

Conjugate:
Unconjugated

Host Species:
Mouse

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Human

Gene Accession No.:
P05783

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Clone:
LDK18

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez):
3875

Primary or Secondary:
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Content And Storage:
4° C

Gene:
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