7218800

AIRE Monoclonal Antibody (TM-724), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Antigen

AIRE

Concentration

0.5 mg/mL

Conjugate

Unconjugated

Host Species

Rat

Target Species

Human

Gene Accession No.

O43918

Isotype

IgG2a κ

Purification Method

Affinity chromatography

Product Type

Antibody

Clone

TM-724

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez)

326

Primary or Secondary

Primary

Content And Storage

4° C

Gene

Aire

Related Products

Img

Fischer Scientific

7218981

Mouse Monoclonal Antibody...

Img

Fischer Scientific

7218897

Rat Monoclonal Antibody...

Img

Fischer Scientific

7218885

Mouse Monoclonal Antibody...

Img

Fischer Scientific

7218713

Mouse Monoclonal Antibody...

Img

Fischer Scientific

7218834

Rat Monoclonal Antibody...

Img

Fischer Scientific

7218743

Rat Monoclonal Antibody...

Img

Fischer Scientific

7218707

Rat Monoclonal Antibody...

Img

Fischer Scientific

7218707

Rat Monoclonal Antibody...

Description

  • This TM-724 MAb reacts with human Autoimmune Regulator (AIRE)
  • This 58 kDa transcription factor is highly expressed within the perinuclear region of mature medullary thymic epithelial cells (mTECs)
  • AIRE mRNA in the periphery has been observed in the lymph node, fetal liver, and intestines
  • Furthermore expression has been observed in dendritic cells, epithelial cells and PBMCs
  • Studies demonstrate that AIRE is involved in thymocyte development, in particular the regulation of tissue-specific antigen expression during negative selection
  • Other biological functions for AIRE include chemokine expression and antigen presentation
  • As a result of alternative splicing, three isoforms have been reported
  • The conditions autoimmune-polyendocrinopathy-candiasis-ectodermal-dystrophy (APECED) and autoimmune polyglandular syndrome type 1 (APS-1) arise from mutations in the human AIRE gene
  • The TM-724 antibody is predicted to recognize all three isoforms of human AIRE (AIRE-1, AIRE-2, AIRE-3)
  • AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression
  • A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes
  • It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP
  • Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD)
  • AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity
  • Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

Compare Similar Items

Show Difference

Img

Fischer Scientific

7218800

Rat Monoclonal Antibody...


Antigen:
AIRE

Concentration:
0.5 mg/mL

Conjugate:
Unconjugated

Host Species:
Rat

Target Species:
Human

Gene Accession No.:
O43918

Isotype:
IgG2a κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Clone:
TM-724

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez):
326

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
Aire

Img

Fischer Scientific

7218802

Mouse Monoclonal Antibody...


Antigen:
CD83

Concentration:
0.5 mg/mL

Conjugate:
Unconjugated

Host Species:
Mouse

Target Species:
Human

Gene Accession No.:
Q01151

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Clone:
HB15e

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
__

Gene ID (Entrez):
9308

Primary or Secondary:
Primary

Content And Storage:
__

Gene:
CD83

Img

Fischer Scientific

7218802

Mouse Monoclonal Antibody...


Antigen:
CD83

Concentration:
0.5 mg/mL

Conjugate:
Unconjugated

Host Species:
Mouse

Target Species:
Human

Gene Accession No.:
Q01151

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Clone:
HB15e

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
__

Gene ID (Entrez):
9308

Primary or Secondary:
Primary

Content And Storage:
__

Gene:
CD83

Img

Fischer Scientific

7218802

Mouse Monoclonal Antibody...


Antigen:
CD83

Concentration:
0.5 mg/mL

Conjugate:
Unconjugated

Host Species:
Mouse

Target Species:
Human

Gene Accession No.:
Q01151

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Clone:
HB15e

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
__

Gene ID (Entrez):
9308

Primary or Secondary:
Primary

Content And Storage:
__

Gene:
CD83