CD365 (Tim-1) Monoclonal Antibody (RMT1-4), eBioscience™, Invitrogen™

Description

• The RMT1-4 MAb reacts with mouse CD365 (also known as TIM1 and HAVCR1) and is a member of the T cell immunoglobulin domain, mucin-like domain (TIM) gene family
• CD365 has been found on activated CD4+ T cells, mast cells, and a subset of B cells
• CD365 is involved in renal injury, tissue homeostasis, and T cell costimulation
• CD365 promotes the differentiation of Th2 cells and the production of IL-4
• CD365 can bind several ligands, including Hepatitis A virus, phosphatidylserine, TIM4, IgA, as well as itself
• CD365 and TIM4 can mediate uptake of apoptotic cells through recognition of phosphatidylserine
• CD365, as well as the other TIM family members, are associated with susceptibility to atopic and autoimmune diseases
• In humans, certain polymorphic variants of CD365 are strongly associated with protection against atopy, and this association occurs only in individuals who have had past infection with hepatitis A virus (HAV)
• CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail
• The endogenous ligand for CD365 is Tim-4
• In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus
• The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes
• Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity
• CD365 has also been implicated in the T cell co-stimulation
• CD365 is primarily expressed in epithelial cells
• It is also highly expressed in A549, 769-P and Caco-2 and cell lines
• CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.