7245325

CCL4 Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

CCL4

Applications

ELISA, Western Blot

Conjugate

Biotin

Host Species

Rabbit

Target Species

Mouse

Gene Accession No.

P14097

Gene ID (Entrez)

20303

Immunogen

E.coli-derived Recombinant Murine MIP-1beta (CCL4)

Purification Method

Antigen affinity chromatography

Gene

CCL4

Concentration

0.1-1.0 mg/mL

Classification

Polyclonal

Form

Lyophilized

Regulatory Status

RUO

Formulation

PBS with no preservative

Gene Alias

ACT2; ACT-2; AT744.1; CC chemokine ligand 4; C-C motif chemokine 4; C-C motif chemokine ligand 4; Ccl4; chemokine (C-C motif) ligand 4; G-26; G-26 T-lymphocyte-secreted protein; HC21; immune activation gene 2; immune activation gene-2; immune activation protein 2; LAG1; LAG-1; Lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; macrophage inflammatory protein-1 beta; MGC104418; MGC126025; MGC126026; MIP-1 beta; MIP1b; MIP-1B; Mip1-b; MIP1B1; MIP1beta; MIP-1BETA; MIP-1-beta; MIP1-beta; MIP-1-beta(1-69); MIP-1-beta(3-69); PAT 744; Protein H400; putative MIP-1beta protein; RP23-320E6.8; SCY4A; SCYA2; Scya4; secreted protein G-26; SIS-gamma; small inducible cytokine A4; small inducible cytokine A4 (homologous to mouse Mip-1b); small-inducible cytokine A4; T-cell activation protein 2

Gene Symbols

CCL4

Primary or Secondary

Primary

Content And Storage

-20°C

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Description

  • AA Sequence of recombinant protein: APMGSDPPTS CCFSYTSRQL HRSFVMDYYE TSSLCSKPAV VFLTKRGRQI CANPSEPWVT EYMSDLELN
  • Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Murine MIP-1beta (CCL4)
  • Anti-Murine MIP-1beta (CCL4)-specific antibody was purified by affinity chromatography and then biotinylated
  • Sandwich ELISA: To detect Murine MIP-1beta by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25-1.0 μg/mL of this antibody is required
  • This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Murine MIP-1beta (500-P213) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Murine MIP-1beta
  • Western Blot: To detect Murine MIP-1beta by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL
  • When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Murine MIP-1beta is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions
  • 500-P213BT-1MG will be provided as 2 x 500 μg CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family
  • Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis
  • CCL4 is produced by macrophages upon stimulation by bacterial endotoxins
  • CCL4 recruits and stimulates various inflammatory cells at sites of inflammation
  • CCL4 is produced by lymphocytes, macrophages and dendritic cells
  • Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells
  • While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes
  • Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells
  • The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells
  • CCL4 binds with high affinity to CCR5 receptors.

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Rabbit Polyclonal Antibody...


Antigen:
CCL4

Applications:
ELISA, Western Blot

Conjugate:
Biotin

Host Species:
Rabbit

Target Species:
Mouse

Gene Accession No.:
P14097

Gene ID (Entrez):
20303

Immunogen:
E.coli-derived Recombinant Murine MIP-1beta (CCL4)

Purification Method:
Antigen affinity chromatography

Gene:
CCL4

Concentration:
0.1-1.0 mg/mL

Classification:
Polyclonal

Form:
Lyophilized

Regulatory Status:
RUO

Formulation:
PBS with no preservative

Gene Alias:
ACT2; ACT-2; AT744.1; CC chemokine ligand 4; C-C motif chemokine 4; C-C motif chemokine ligand 4; Ccl4; chemokine (C-C motif) ligand 4; G-26; G-26 T-lymphocyte-secreted protein; HC21; immune activation gene 2; immune activation gene-2; immune activation protein 2; LAG1; LAG-1; Lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; macrophage inflammatory protein-1 beta; MGC104418; MGC126025; MGC126026; MIP-1 beta; MIP1b; MIP-1B; Mip1-b; MIP1B1; MIP1beta; MIP-1BETA; MIP-1-beta; MIP1-beta; MIP-1-beta(1-69); MIP-1-beta(3-69); PAT 744; Protein H400; putative MIP-1beta protein; RP23-320E6.8; SCY4A; SCYA2; Scya4; secreted protein G-26; SIS-gamma; small inducible cytokine A4; small inducible cytokine A4 (homologous to mouse Mip-1b); small-inducible cytokine A4; T-cell activation protein 2

Gene Symbols:
CCL4

Primary or Secondary:
Primary

Content And Storage:
-20°C

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Antigen:
CNTF

Applications:
ELISA, Western Blot

Conjugate:
Unconjugated

Host Species:
Rabbit

Target Species:
__

Gene Accession No.:
P20294

Gene ID (Entrez):
25707

Immunogen:
E.coli-derived Recombinant Rat CNTF

Purification Method:
Antigen affinity chromatography

Gene:
CNTF

Concentration:
0.1-1.0 mg/mL

Classification:
Polyclonal

Form:
Lyophilized

Regulatory Status:
RUO

Formulation:
PBS with no preservative

Gene Alias:
AI429687; Ciliary neurotrophic factor; ciliary neurotropic factor; Cntf; HCNTF; H-CNTF

Gene Symbols:
CNTF

Primary or Secondary:
Primary

Content And Storage:
__

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Antigen:
SCF

Applications:
ELISA, Western Blot

Conjugate:
Unconjugated

Host Species:
Rabbit

Target Species:
Human

Gene Accession No.:
P21583

Gene ID (Entrez):
4254

Immunogen:
E.coli-derived Recombinant Human SCF

Purification Method:
Antigen affinity chromatography

Gene:
KITLG

Concentration:
0.1-1.0 mg/mL

Classification:
Polyclonal

Form:
Lyophilized

Regulatory Status:
RUO

Formulation:
PBS with no preservative

Gene Alias:
710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF

Gene Symbols:
KITLG

Primary or Secondary:
Primary

Content And Storage:
-20°C

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Antigen:
TNF alpha

Applications:
ELISA, Western Blot

Conjugate:
Unconjugated

Host Species:
Goat

Target Species:
Human

Gene Accession No.:
P01375

Gene ID (Entrez):
7124

Immunogen:
E.coli-derived Recombinant Human TNF-alpha

Purification Method:
Antigen affinity chromatography

Gene:
Tnf

Concentration:
0.1-1.0 mg/mL

Classification:
Polyclonal

Form:
Lyophilized

Regulatory Status:
RUO

Formulation:
PBS with no preservative

Gene Alias:
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor

Gene Symbols:
Tnf

Primary or Secondary:
__

Content And Storage:
-20°C