7245387

CD178 (soluble) Polyclonal Antibody, PeproTech®, Invitrogen™

Goat Polyclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

CD178 (soluble)

Applications

ELISA, Western Blot

Conjugate

Unconjugated

Host Species

Goat

Target Species

Human

Gene Accession No.

P48023

Gene ID (Entrez)

356

Immunogen

CHO cells-derived Recombinant Human sFas Ligand

Purification Method

Antigen affinity chromatography

Gene

Faslg

Concentration

0.1-1.0 mg/mL

Classification

Polyclonal

Form

Lyophilized

Regulatory Status

RUO

Formulation

PBS with no preservative

Gene Alias

ADAM10-processed FasL form; ALPS1B; APL; Apoptosis (APO 1) antigen ligand 1; apoptosis (APO-1) antigen ligand 1; Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand); apoptosis antigen ligand; APT1LG1; APTL; CD178; CD178 antigen; CD95 ligand; CD95 ligand protein;Generalized lymphoproliferative disease (Gld); Cd95l; CD95-L; CD95L protein; fas antigen ligand; Fas ligand; Fas ligand (TNF superfamily, member 6); Fasl; Fas-L; FasL ICD; FasL intracellular domain; Faslg; Fas-LG; generalized lymphoproliferative disease; gld; mutant tumor necrosis factor family member 6; Receptor-binding FasL ectodomain; sFasL; Soluble Fas ligand; soluble form; SPA; SPPL2A-processed FasL form; TNFL; Tnfsf6; TNLG1A; Tumor necrosis factor (ligand) superfamily member 6; Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand); Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand); Tumor necrosis factor

Gene Symbols

Faslg

Primary or Secondary

Primary

Content And Storage

-20°C

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Description

  • AA Sequence of recombinant protein: HHHHHHHHPS PPPEKKELRK VAHLTGKSNS RSMPLEWEDT YGIVLLSGVK YKKGGLVINE TGLYFVYSKV YFRGQSCNNL PLSHKVYMRN SKYPQDLVMM EGKMMSYCTT GQMWARSSYL GAVFNLTSAD HLYVNVSELS LVNFEESQTF FGLYKL
  • Preparation: Produced from sera of goats immunized with highly pure Recombinant Human sFas Ligand
  • Anti-Human sFas Ligand-specific antibody was purified by affinity chromatography employing an immobilized Human sFas Ligand matrix
  • Sandwich ELISA: To detect Human sFas Ligand by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required
  • This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human sFas Ligand (500-P184GBt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human sFas Ligand
  • Western Blot: To detect Human sFas Ligand by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL
  • Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human sFasLigand is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions
  • CD178 (Fas ligand, FasL) is a type-II-membrane protein, whose N-terminus is in the cytoplasm and its C-terminal region extends into the extracellular space
  • Its receptor, FasR, is a cell-surface-type-I-membrane protein and a member of the tumor necrosis factor (TNF) and nerve growth factor (NGF) receptor family
  • As a member of the TNF-cytokine family CD178 induces apoptosis when interacting with FasR
  • CD178 may exist as either membrane bound (45 kD) or soluble forms (26 kD)
  • The soluble protein can be released from cells upon cleavage by metalloproteinases
  • Binding of CD178 to Fas leads to oligomerization of the receptor and triggers apoptotic cell death through the interaction of other proteins
  • CD178 is predominantly expressed in activated T-lymphocytes and natural killer (NK) cells also it is expressed in the tissues of immune-privilege sites such as testis and eye
  • CD178 expression is also reported in various tissues as thymus, liver, ovary, lung, heart and kidney
  • It is assumed that induction of apoptosis through CD178 is predominantly involved in anti-viral immune responses
  • CD178 is a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis
  • Various cells express FAS, where CD178 is expressed predominantly on activated T cells
  • FAS and CD178 are involved in the down-regulation of immune reactions as well as T cell-mediated cytotoxicity
  • CD178 concentration has also been shown to be associated with atherosclerosis and inflammatory disease, in patients with hypertension
  • The Fas/ CD178 system has been shown to play a role in a number of human diseases, for example AIDS, hepatitis or cancer.

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Antigen:
CD178 (soluble)

Applications:
ELISA, Western Blot

Conjugate:
Unconjugated

Host Species:
Goat

Target Species:
Human

Gene Accession No.:
P48023

Gene ID (Entrez):
356

Immunogen:
CHO cells-derived Recombinant Human sFas Ligand

Purification Method:
Antigen affinity chromatography

Gene:
Faslg

Concentration:
0.1-1.0 mg/mL

Classification:
Polyclonal

Form:
Lyophilized

Regulatory Status:
RUO

Formulation:
PBS with no preservative

Gene Alias:
ADAM10-processed FasL form; ALPS1B; APL; Apoptosis (APO 1) antigen ligand 1; apoptosis (APO-1) antigen ligand 1; Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand); apoptosis antigen ligand; APT1LG1; APTL; CD178; CD178 antigen; CD95 ligand; CD95 ligand protein;Generalized lymphoproliferative disease (Gld); Cd95l; CD95-L; CD95L protein; fas antigen ligand; Fas ligand; Fas ligand (TNF superfamily, member 6); Fasl; Fas-L; FasL ICD; FasL intracellular domain; Faslg; Fas-LG; generalized lymphoproliferative disease; gld; mutant tumor necrosis factor family member 6; Receptor-binding FasL ectodomain; sFasL; Soluble Fas ligand; soluble form; SPA; SPPL2A-processed FasL form; TNFL; Tnfsf6; TNLG1A; Tumor necrosis factor (ligand) superfamily member 6; Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand); Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand); Tumor necrosis factor

Gene Symbols:
Faslg

Primary or Secondary:
Primary

Content And Storage:
-20°C

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Applications:
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Conjugate:
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Host Species:
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Target Species:
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Gene ID (Entrez):
20308

Immunogen:
E.coli-derived Recombinant Murine MIP-1gamma (CCL9/10)

Purification Method:
Antigen affinity chromatography

Gene:
Ccl9

Concentration:
0.1-1.0 mg/mL

Classification:
Polyclonal

Form:
Lyophilized

Regulatory Status:
RUO

Formulation:
PBS with no preservative

Gene Alias:
C-C motif chemokine 9; CCF18; Ccl9; CCL9(29-101); CCL9(30-101); CCL9(31-101); chemokine (C-C motif) ligand 9; chemokine CCL9; macrophage inflammatory protein 1-gamma; Macrophage inflammatory protein-related protein 2; MIP-1 gamma; MIP-1-gamma; Mrp2; MRP-2; RP23-320E6.3; Scya10; Scya9; small inducible cytokine A10; small inducible cytokine A9; Small-inducible cytokine A9

Gene Symbols:
Ccl9

Primary or Secondary:
Primary

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Applications:
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Conjugate:
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Host Species:
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Target Species:
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Gene Accession No.:
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Gene ID (Entrez):
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Immunogen:
M. avium cell extract.

Purification Method:
Protein A

Gene:
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Concentration:
0.9 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with no preservative; pH 7.4

Gene Alias:
m avium; M. avium

Gene Symbols:
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Primary or Secondary:
Primary

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

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Antigen:
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Applications:
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Conjugate:
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Host Species:
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Target Species:
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Gene Accession No.:
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Gene ID (Entrez):
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Immunogen:
M. avium cell extract.

Purification Method:
Protein A

Gene:
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Concentration:
0.9 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with no preservative; pH 7.4

Gene Alias:
m avium; M. avium

Gene Symbols:
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Primary or Secondary:
Primary

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles