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89-934-266

HLA-DQ Mouse anti-Human, Clone: SPM422, Abnova™

Manufacturer: Abnova Corporation

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Pack Size SKU Availability Price
Each of 1 89-934-266-Each-of-1 In Stock ₹ 64,426.68

89-934-266 - Each of 1

₹ 64,426.68

In Stock

Quantity

1

Base Price: ₹ 64,426.68

GST (18%): ₹ 11,596.802

Total Price: ₹ 76,023.482

Antigen

HLA-DQ

Classification

Monoclonal

Conjugate

Unconjugated

Dilution

Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.

Gene Alias

CD/CELIAC1/DQ-A1/FLJ27088/FLJ27328/GSE/HLA-DQA/MGC149527

Host Species

Mouse

Purification Method

Protein A/G purification

Regulatory Status

RUO

Gene ID (Entrez)

3117/3118/3119

Target Species

Human

Form

Liquid

Applications

Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)

Clone

SPM422

Description

Mouse monoclonal antibody raised against native human HLA-DQ.

Formulation

In 10mM PBS (0.05% BSA, 0.05% sodium azide).

Gene Symbols

HLA-DQA1

Immunogen

T4-positive CTL clone HG-38.

Quantity

100 μg

Primary or Secondary

Primary

Test Specificity

Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. This monoclonal antibody strongly blocks cytotoxicity activity of T4+cytotoxic T cell clones.

Content And Storage

Store at 4°C.

Isotype

IgG2a κ

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Description

  • HLA-DQB1 belongs to the HLA class II beta chain paralogues
  • This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane
  • It plays a central role in the immune system by presenting peptides derived from extracellular proteins
  • Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages)
  • The beta chain is approximately 26-28 kDa and it contains 6 exons
  • Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail
  • Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules
  • Typing for these polymorphisms is routinely done for bone marrow transplantation
  • [provided by RefSeq]

Compare Similar Items

Show Difference

Img

Abnova Corporation

89-934-266

--

Antigen:
HLA-DQ
Classification:
Monoclonal
Conjugate:
Unconjugated
Dilution:
Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
Gene Alias:
CD/CELIAC1/DQ-A1/FLJ27088/FLJ27328/GSE/HLA-DQA/MGC149527
Host Species:
Mouse
Purification Method:
Protein A/G purification
Regulatory Status:
RUO
Gene ID (Entrez):
3117/3118/3119
Target Species:
Human
Form:
Liquid
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
Clone:
SPM422
Description:
Mouse monoclonal antibody raised against native human HLA-DQ.
Formulation:
In 10mM PBS (0.05% BSA, 0.05% sodium azide).
Gene Symbols:
HLA-DQA1
Immunogen:
T4-positive CTL clone HG-38.
Quantity:
100 μg
Primary or Secondary:
Primary
Test Specificity:
Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. This monoclonal antibody strongly blocks cytotoxicity activity of T4+cytotoxic T cell clones.
Content And Storage:
Store at 4°C.
Isotype:
IgG2a κ

Img

Abnova Corporation

89-934-268

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Antigen:
HLA-DR
Classification:
Monoclonal
Conjugate:
Unconjugated
Dilution:
Flow Cytometry (1:50-1:100) Immunohistochemistry (Frozen sections) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL) The optimal working dilution should be determined by the end user.
Gene Alias:
__
Host Species:
Rat
Purification Method:
Affinity purification
Regulatory Status:
RUO
Gene ID (Entrez):
__
Target Species:
Human
Form:
Liquid
Applications:
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed)
Clone:
YE2/36 HLK
Description:
Rat monoclonal antibody raised against human HLA-DR.
Formulation:
In PBS (0.09% sodium azide).
Gene Symbols:
__
Immunogen:
eHR-B Ramos cells
Quantity:
125 μg
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Isotype:
IgG2a

Img

Abnova Corporation

89-934-269

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Antigen:
HLA-DR
Classification:
Monoclonal
Conjugate:
Unconjugated
Dilution:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user.
Gene Alias:
__
Host Species:
Mouse
Purification Method:
__
Regulatory Status:
RUO
Gene ID (Entrez):
__
Target Species:
Human
Form:
Liquid
Applications:
Immunohistochemistry (PFA fixed)
Clone:
LN-3
Description:
Mouse monoclonal antibody raised against human HLA-DR.
Formulation:
In tissue culture supernatant (0.7% BSA, 0.09% sodium azide).
Gene Symbols:
__
Immunogen:
Human HLA-DR
Quantity:
250 μL
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Store at 4°C.Aliquot to avoid repeated freezing and thawing.
Isotype:
IgG2b

Img

Abnova Corporation

89-934-270

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Antigen:
HLA-DRB
Classification:
Monoclonal
Conjugate:
Unconjugated
Dilution:
Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d
Gene Alias:
DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1
Host Species:
Mouse
Purification Method:
Protein A/G purification
Regulatory Status:
RUO
Gene ID (Entrez):
3123
Target Species:
Human
Form:
Liquid
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone:
SPM289
Description:
Mouse monoclonal antibody raised against native human HLA-DRB.
Formulation:
In 10mM PBS (0.05% BSA, 0.05% sodium azide).
Gene Symbols:
HLA-DRB1
Immunogen:
Activated human peripheral blood mononuclear cells.
Quantity:
100 μg
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the HLA-DRB monoclonal antibody, clone SPM289, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
Content And Storage:
Store at 4°C.
Isotype:
IgG2b κ