89-934-270
HLA-DRB Mouse anti-Human, Clone: SPM289, Abnova™
Manufacturer: Abnova Corporation
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-934-270-Each-of-1 | In Stock | ₹ 64,426.68 |
89-934-270 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 64,426.68
GST (18%): ₹ 11,596.802
Total Price: ₹ 76,023.482
Antigen
HLA-DRB
Classification
Monoclonal
Conjugate
Unconjugated
Dilution
Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d
Gene Alias
DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1
Host Species
Mouse
Purification Method
Protein A/G purification
Regulatory Status
RUO
Gene ID (Entrez)
3123
Target Species
Human
Form
Liquid
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone
SPM289
Description
Mouse monoclonal antibody raised against native human HLA-DRB.
Formulation
In 10mM PBS (0.05% BSA, 0.05% sodium azide).
Gene Symbols
HLA-DRB1
Immunogen
Activated human peripheral blood mononuclear cells.
Quantity
100 μg
Primary or Secondary
Primary
Test Specificity
This monoclonal antibody reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the HLA-DRB monoclonal antibody, clone SPM289, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
Content And Storage
Store at 4°C.
Isotype
IgG2b κ
Related Products
Description
- HLA-DRB1 belongs to the HLA class II beta chain paralogs
- The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane
- It plays a central role in the immune system by presenting peptides derived from extracellular proteins
- Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages)
- The beta chain is approximately 26-28 kDa
- It is encoded by 6 exons
- Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail
- Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities
- Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation
- DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5
- DRB1 is present in all individuals
- Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5
- There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9
- [provided by RefSeq]
Compare Similar Items
Show Difference
Antigen: HLA-DRB
Classification: Monoclonal
Conjugate: Unconjugated
Dilution: Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d
Gene Alias: DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1
Host Species: Mouse
Purification Method: Protein A/G purification
Regulatory Status: RUO
Gene ID (Entrez): 3123
Target Species: Human
Form: Liquid
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone: SPM289
Description: Mouse monoclonal antibody raised against native human HLA-DRB.
Formulation: In 10mM PBS (0.05% BSA, 0.05% sodium azide).
Gene Symbols: HLA-DRB1
Immunogen: Activated human peripheral blood mononuclear cells.
Quantity: 100 μg
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the HLA-DRB monoclonal antibody, clone SPM289, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
Content And Storage: Store at 4°C.
Isotype: IgG2b κ
Antigen:
HLA-DRB
Classification:
Monoclonal
Conjugate:
Unconjugated
Dilution:
Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d
Gene Alias:
DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1
Host Species:
Mouse
Purification Method:
Protein A/G purification
Regulatory Status:
RUO
Gene ID (Entrez):
3123
Target Species:
Human
Form:
Liquid
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone:
SPM289
Description:
Mouse monoclonal antibody raised against native human HLA-DRB.
Formulation:
In 10mM PBS (0.05% BSA, 0.05% sodium azide).
Gene Symbols:
HLA-DRB1
Immunogen:
Activated human peripheral blood mononuclear cells.
Quantity:
100 μg
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the HLA-DRB monoclonal antibody, clone SPM289, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
Content And Storage:
Store at 4°C.
Isotype:
IgG2b κ
Antigen: HLA-DRB1
Classification: Monoclonal
Conjugate: Unconjugated
Dilution: Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d
Gene Alias: DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1
Host Species: Mouse
Purification Method: Protein A/G purification
Regulatory Status: RUO
Gene ID (Entrez): 3123
Target Species: Human
Form: Liquid
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone: HLA-DRB/1067
Description: Mouse monoclonal antibody raised against native human HLA-DRB1.
Formulation: In 10mM PBS.
Gene Symbols: HLA-DRB1
Immunogen: Activated human peripheral blood mononuclear cells.
Quantity: 100 μg
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody reacts with the beta chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B cell lymphoma.
Content And Storage: Store at -20 to -80°C.Aliquot to avoid repeated freezing and thawing.
Isotype: IgG2b κ
Antigen:
HLA-DRB1
Classification:
Monoclonal
Conjugate:
Unconjugated
Dilution:
Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d
Gene Alias:
DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1
Host Species:
Mouse
Purification Method:
Protein A/G purification
Regulatory Status:
RUO
Gene ID (Entrez):
3123
Target Species:
Human
Form:
Liquid
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone:
HLA-DRB/1067
Description:
Mouse monoclonal antibody raised against native human HLA-DRB1.
Formulation:
In 10mM PBS.
Gene Symbols:
HLA-DRB1
Immunogen:
Activated human peripheral blood mononuclear cells.
Quantity:
100 μg
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody reacts with the beta chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B cell lymphoma.
Content And Storage:
Store at -20 to -80°C.Aliquot to avoid repeated freezing and thawing.
Isotype:
IgG2b κ
Antigen: HLA-DRB1
Classification: Monoclonal
Conjugate: Unconjugated
Dilution: Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d
Gene Alias: DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1
Host Species: Mouse
Purification Method: Protein A/G purification
Regulatory Status: RUO
Gene ID (Entrez): 3123
Target Species: Human
Form: Liquid
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone: LN-3
Description: Mouse monoclonal antibody raised against native human HLA-DRB1.
Formulation: In 10mM PBS.
Gene Symbols: HLA-DRB1
Immunogen: Activated human peripheral blood mononuclear cells.
Quantity: 100 μg
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B cell lymphoma.
Content And Storage: Store at -20 to -80°C.Aliquot to avoid repeated freezing and thawing.
Isotype: IgG2b κ
Antigen:
HLA-DRB1
Classification:
Monoclonal
Conjugate:
Unconjugated
Dilution:
Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d
Gene Alias:
DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1
Host Species:
Mouse
Purification Method:
Protein A/G purification
Regulatory Status:
RUO
Gene ID (Entrez):
3123
Target Species:
Human
Form:
Liquid
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone:
LN-3
Description:
Mouse monoclonal antibody raised against native human HLA-DRB1.
Formulation:
In 10mM PBS.
Gene Symbols:
HLA-DRB1
Immunogen:
Activated human peripheral blood mononuclear cells.
Quantity:
100 μg
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B cell lymphoma.
Content And Storage:
Store at -20 to -80°C.Aliquot to avoid repeated freezing and thawing.
Isotype:
IgG2b κ
Antigen: HLA-DRB1
Classification: Monoclonal
Conjugate: Unconjugated
Dilution: Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d
Gene Alias: DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1
Host Species: Mouse
Purification Method: Protein A/G purification
Regulatory Status: RUO
Gene ID (Entrez): 3123
Target Species: Human
Form: Liquid
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone: SPM288
Description: Mouse monoclonal antibody raised against native human HLA-DRB1.
Formulation: In 10mM PBS (0.05% BSA, 0.05% sodium azide).
Gene Symbols: HLA-DRB1
Immunogen: Activated human peripheral blood mononuclear cells.
Quantity: 100 μg
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B cell lymphoma.
Content And Storage: Store at 4°C.
Isotype: IgG2b κ
Antigen:
HLA-DRB1
Classification:
Monoclonal
Conjugate:
Unconjugated
Dilution:
Flow Cytometry (0.5-1 ug/106cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) Western Blot (0.5-1 ug/mL) The optimal working dilution should be d
Gene Alias:
DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1
Host Species:
Mouse
Purification Method:
Protein A/G purification
Regulatory Status:
RUO
Gene ID (Entrez):
3123
Target Species:
Human
Form:
Liquid
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Clone:
SPM288
Description:
Mouse monoclonal antibody raised against native human HLA-DRB1.
Formulation:
In 10mM PBS (0.05% BSA, 0.05% sodium azide).
Gene Symbols:
HLA-DRB1
Immunogen:
Activated human peripheral blood mononuclear cells.
Quantity:
100 μg
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B cell lymphoma.
Content And Storage:
Store at 4°C.
Isotype:
IgG2b κ