ABN2178100
Tau (TauC4, Rabbit anti-Human, Polyclonal, Millipore Sigma™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN2178100-Each-of-1 | In Stock | ₹ 41,643.76 |
ABN2178100 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,643.76
GST (18%): ₹ 7,495.877
Total Price: ₹ 49,139.637
Antigen
Tau (TauC4
Classification
Polyclonal
Dilution
Western Blotting Analysis: A representative lot detected Tau (TauC4, 354-369) in Western Blotting applications (Fitzpatrick, A.W.P., et. al. (2017) Nature. 547(7662):185-190; Taniguchi-Watanabe, S., et. al. (2016). Acta Neuropathol. 131(2):267-280).Electron Microscopy Analysis: A representative lot detected Tau (TauC4, 354-369) in Immunogold negative-stain Electron Microscopy applications (Fitzpatrick, A.W.P., et. al. (2017) Nature. 547(7662):185-190).
Gene Alias
Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau
Host Species
Rabbit
Molecular Weight of Antigen
∽55 kDa observed; 45.85 kDa calculated.
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_005901
Target Species
Human
Form
Serum
Applications
Immunomicroscopy, Western Blot
Conjugate
Unconjugated
Formulation
Rabbit polyclonal antiserum with 0.1% sodium azide.
Gene Symbols
MAPT;MAPTL;MTBT1;TAU
Immunogen
KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal half of human Microtubule-associated protein tau, isoform 8 (Tau-F).
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal antibody specifically detects TauC4 region in human Tau protein.
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype
IgG
Related Products
Description
- Anti-Tau (TauC4, 354-369), Cat
- No
- ABN2178, is a highly specific rabbit polyclonal antibody that targets TauC4 region of Tau and has been tested for use in Electron Microscopy and Western Blotting
- Microtubule-associated protein tau (UniProt: P10636; also known as Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau) is encoded by the MAPT (also known as MAPTL, MTBT1, TAU) gene (Gene ID: 4137) in human
- Microtubule-associated protein tau is shown to be expressed in neurons
- It is mostly found in axons, in the cytosol, and in association with plasma membrane components
- Nine isoforms of Tau have been described that are generated by alternative splicing
- Tau proteins promote microtubule assembly and stability and may also be involved in the establishment and maintenance of neuronal polarity
- The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, thus serving as a linker protein between both
- The short isoforms are reported to allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization
- In Alzheimer disease (AD), the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of Tau
- In AD brain Tau accumulates in both the somatodendritic and axonal domains of neurons and it also accumulates in the soma as neurofibrillary tangles (NFTs)
- Tau oligomers are reported to be neurotoxic when applied extracellularly to cultured neuronal cells and can induce neurodegeneration and synaptic and mitochondrial dysfunction in vivo
- It has been reported that most of the C-terminus of Tau (aa 243-406) in PHFs can be cleaved by trypsin, however the TauC4 region is highly resistant to trypsin action
- (Ref.: Taniguchi Watanabe, S., et al
- (2016)
- Acta Neuropathol
- 131(2); 267-280; Ando K., et al
- (2010)
- Biochem
- Soc
- Trans
- 38(4); 1001-1005).
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Antigen: Tau (TauC4
Classification: Polyclonal
Dilution: Western Blotting Analysis: A representative lot detected Tau (TauC4, 354-369) in Western Blotting applications (Fitzpatrick, A.W.P., et. al. (2017) Nature. 547(7662):185-190; Taniguchi-Watanabe, S., et. al. (2016). Acta Neuropathol. 131(2):267-280).Electron Microscopy Analysis: A representative lot detected Tau (TauC4, 354-369) in Immunogold negative-stain Electron Microscopy applications (Fitzpatrick, A.W.P., et. al. (2017) Nature. 547(7662):185-190).
Gene Alias: Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau
Host Species: Rabbit
Molecular Weight of Antigen: ∽55 kDa observed; 45.85 kDa calculated.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_005901
Target Species: Human
Form: Serum
Applications: Immunomicroscopy, Western Blot
Conjugate: Unconjugated
Formulation: Rabbit polyclonal antiserum with 0.1% sodium azide.
Gene Symbols: MAPT;MAPTL;MTBT1;TAU
Immunogen: KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal half of human Microtubule-associated protein tau, isoform 8 (Tau-F).
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody specifically detects TauC4 region in human Tau protein.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG
Antigen:
Tau (TauC4
Classification:
Polyclonal
Dilution:
Western Blotting Analysis: A representative lot detected Tau (TauC4, 354-369) in Western Blotting applications (Fitzpatrick, A.W.P., et. al. (2017) Nature. 547(7662):185-190; Taniguchi-Watanabe, S., et. al. (2016). Acta Neuropathol. 131(2):267-280).Electron Microscopy Analysis: A representative lot detected Tau (TauC4, 354-369) in Immunogold negative-stain Electron Microscopy applications (Fitzpatrick, A.W.P., et. al. (2017) Nature. 547(7662):185-190).
Gene Alias:
Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau
Host Species:
Rabbit
Molecular Weight of Antigen:
∽55 kDa observed; 45.85 kDa calculated.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_005901
Target Species:
Human
Form:
Serum
Applications:
Immunomicroscopy, Western Blot
Conjugate:
Unconjugated
Formulation:
Rabbit polyclonal antiserum with 0.1% sodium azide.
Gene Symbols:
MAPT;MAPTL;MTBT1;TAU
Immunogen:
KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal half of human Microtubule-associated protein tau, isoform 8 (Tau-F).
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody specifically detects TauC4 region in human Tau protein.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG
Antigen: Tau (TauC4
Classification: Polyclonal
Dilution: Western Blotting Analysis: A representative lot detected Tau (TauC4, 354-369) in Western Blotting applications (Fitzpatrick, A.W.P., et. al. (2017) Nature. 547(7662):185-190; Taniguchi-Watanabe, S., et. al. (2016). Acta Neuropathol. 131(2):267-280).Electron Microscopy Analysis: A representative lot detected Tau (TauC4, 354-369) in Immunogold negative-stain Electron Microscopy applications (Fitzpatrick, A.W.P., et. al. (2017) Nature. 547(7662):185-190).
Gene Alias: Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau
Host Species: Rabbit
Molecular Weight of Antigen: ∽55 kDa observed; 45.85 kDa calculated.
Quantity: 25 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_005901
Target Species: Human
Form: Serum
Applications: Immunomicroscopy, Western Blot
Conjugate: Unconjugated
Formulation: Rabbit polyclonal antiserum with 0.1% sodium azide.
Gene Symbols: MAPT;MAPTL;MTBT1;TAU
Immunogen: KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal half of human Microtubule-associated protein tau, isoform 8 (Tau-F).
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody specifically detects TauC4 region in human Tau protein.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG
Antigen:
Tau (TauC4
Classification:
Polyclonal
Dilution:
Western Blotting Analysis: A representative lot detected Tau (TauC4, 354-369) in Western Blotting applications (Fitzpatrick, A.W.P., et. al. (2017) Nature. 547(7662):185-190; Taniguchi-Watanabe, S., et. al. (2016). Acta Neuropathol. 131(2):267-280).Electron Microscopy Analysis: A representative lot detected Tau (TauC4, 354-369) in Immunogold negative-stain Electron Microscopy applications (Fitzpatrick, A.W.P., et. al. (2017) Nature. 547(7662):185-190).
Gene Alias:
Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau
Host Species:
Rabbit
Molecular Weight of Antigen:
∽55 kDa observed; 45.85 kDa calculated.
Quantity:
25 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_005901
Target Species:
Human
Form:
Serum
Applications:
Immunomicroscopy, Western Blot
Conjugate:
Unconjugated
Formulation:
Rabbit polyclonal antiserum with 0.1% sodium azide.
Gene Symbols:
MAPT;MAPTL;MTBT1;TAU
Immunogen:
KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal half of human Microtubule-associated protein tau, isoform 8 (Tau-F).
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody specifically detects TauC4 region in human Tau protein.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG
Antigen: Synaptotagmin-1
Classification: Polyclonal
Dilution: __
Gene Alias: __
Host Species: Rabbit
Molecular Weight of Antigen: __
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Rat
Form: Purified
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate: Unconjugated
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: __
Immunogen: BSA-conjugated linear peptide corresponding to the first 23 amino acids from the N-terminal vesicular domain of rat Synaptotagmin-1.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype: IgG
Antigen:
Synaptotagmin-1
Classification:
Polyclonal
Dilution:
__
Gene Alias:
__
Host Species:
Rabbit
Molecular Weight of Antigen:
__
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Rat
Form:
Purified
Applications:
Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate:
Unconjugated
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
__
Immunogen:
BSA-conjugated linear peptide corresponding to the first 23 amino acids from the N-terminal vesicular domain of rat Synaptotagmin-1.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype:
IgG
Antigen: Synaptotagmin-1
Classification: Polyclonal
Dilution: __
Gene Alias: __
Host Species: Rabbit
Molecular Weight of Antigen: __
Quantity: 25 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Rat
Form: Purified
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate: Unconjugated
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: __
Immunogen: BSA-conjugated linear peptide corresponding to the first 23 amino acids from the N-terminal vesicular domain of rat Synaptotagmin-1.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype: IgG
Antigen:
Synaptotagmin-1
Classification:
Polyclonal
Dilution:
__
Gene Alias:
__
Host Species:
Rabbit
Molecular Weight of Antigen:
__
Quantity:
25 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Rat
Form:
Purified
Applications:
Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate:
Unconjugated
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
__
Immunogen:
BSA-conjugated linear peptide corresponding to the first 23 amino acids from the N-terminal vesicular domain of rat Synaptotagmin-1.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype:
IgG