AHB0061
Tau (Cleaved Asp421, Asp422) Monoclonal Antibody (TauC3), Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | AHB0061-Each-of-1 | In Stock | ₹ 38,502.00 |
AHB0061 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,502.00
GST (18%): ₹ 6,930.36
Total Price: ₹ 45,432.36
Antigen
Tau (Cleaved Asp421, Asp422)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 1% BSA and 0.1% sodium azide; pH 7.2
Gene Accession No.
P10636, P10637, P19332
Gene Symbols
MAPT
Immunogen
KLH-CSSTGSIDMVD, corresponding to the C terminus of tau truncated at Asp421.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
TauC3
Conjugate
Unconjugated
Gene
MAPT
Gene Alias
map tau; microtubules; neurofibrillary tangles
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17762, 29477, 4137
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- This antibody recognizes tau when truncated at Asp421
- Several caspases, including caspase-3, caspase-7, and caspase-8, cleave tau at this site, yielding the truncated form of the protein
- This antibody does not react with full-length tau, or with tau truncated at Glu391 or Ala429
- This antibody provides a tool for studying neuronal cell apoptosis
- Recommended Positive Control: Tau and caspase-3 cleaved tau
- Tau is a neuronal microtubule-associated protein found predominantly on axons
- The function of Tau is to promote tubulin polymerization and stabilize microtubules
- The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both
- Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome
- The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization
- In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain
- Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, μgtimately leading to the degeneration of the affected neurons
- Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II
- Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Compare Similar Items
Show Difference
Antigen: Tau (Cleaved Asp421, Asp422)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 1% BSA and 0.1% sodium azide; pH 7.2
Gene Accession No.: P10636, P10637, P19332
Gene Symbols: MAPT
Immunogen: KLH-CSSTGSIDMVD, corresponding to the C terminus of tau truncated at Asp421.
Quantity: 50 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1 κ
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: TauC3
Conjugate: Unconjugated
Gene: MAPT
Gene Alias: map tau; microtubules; neurofibrillary tangles
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17762, 29477, 4137
Content And Storage: -20°C
Form: Liquid
Antigen:
Tau (Cleaved Asp421, Asp422)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 1% BSA and 0.1% sodium azide; pH 7.2
Gene Accession No.:
P10636, P10637, P19332
Gene Symbols:
MAPT
Immunogen:
KLH-CSSTGSIDMVD, corresponding to the C terminus of tau truncated at Asp421.
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
TauC3
Conjugate:
Unconjugated
Gene:
MAPT
Gene Alias:
map tau; microtubules; neurofibrillary tangles
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17762, 29477, 4137
Content And Storage:
-20°C
Form:
Liquid
Antigen: alpha Synuclein
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.1% BSA and 0.1% sodium azide; pH 7.2
Gene Accession No.: P37840
Gene Symbols: SNCA
Immunogen: Recombinant human alpha-synuclein.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: Syn 211
Conjugate: Unconjugated
Gene: SNCA
Gene Alias: Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
Host Species: Mouse
Purification Method: Protein A/G
Regulatory Status: RUO
Gene ID (Entrez): 6622
Content And Storage: Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Form: Liquid
Antigen:
alpha Synuclein
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.1% BSA and 0.1% sodium azide; pH 7.2
Gene Accession No.:
P37840
Gene Symbols:
SNCA
Immunogen:
Recombinant human alpha-synuclein.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
Syn 211
Conjugate:
Unconjugated
Gene:
SNCA
Gene Alias:
Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
Host Species:
Mouse
Purification Method:
Protein A/G
Regulatory Status:
RUO
Gene ID (Entrez):
6622
Content And Storage:
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Form:
Liquid
Antigen: beta Amyloid (1-20)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.1% sodium azide; pH 7.2
Gene Accession No.: P05067, P08592
Gene Symbols: APP
Immunogen: The immunogen used in the production of this monoclonal antibody is a chemically synthesized peptide corresponding to amino acid residues 1-20 of A-beta (beta-amyloid) peptide.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG1 κ
Applications: ELISA, Western Blot
Clone: 7N22
Conjugate: Unconjugated
Gene: APP
Gene Alias: A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; Amyloid; amyloid A4; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; amyloid precursor protein variant 1; amyloid precursor protein variant 2; Amyloid β; amyloid-beta A4 protein; amyloid-beta A4 protein; amyloid beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta amyloid protein; beta amyloid protein precursor; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); Beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTF gamma; CTF-alpha; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; OTTHUMP00000096096; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; PreA4 751; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
Host Species: Mouse
Purification Method: purified
Regulatory Status: RUO
Gene ID (Entrez): 351, 54226
Content And Storage: -20°C
Form: Liquid
Antigen:
beta Amyloid (1-20)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.1% sodium azide; pH 7.2
Gene Accession No.:
P05067, P08592
Gene Symbols:
APP
Immunogen:
The immunogen used in the production of this monoclonal antibody is a chemically synthesized peptide corresponding to amino acid residues 1-20 of A-beta (beta-amyloid) peptide.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
ELISA, Western Blot
Clone:
7N22
Conjugate:
Unconjugated
Gene:
APP
Gene Alias:
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; Amyloid; amyloid A4; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; amyloid precursor protein variant 1; amyloid precursor protein variant 2; Amyloid β; amyloid-beta A4 protein; amyloid-beta A4 protein; amyloid beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta amyloid protein; beta amyloid protein precursor; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); Beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTF gamma; CTF-alpha; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; OTTHUMP00000096096; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; PreA4 751; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
Host Species:
Mouse
Purification Method:
purified
Regulatory Status:
RUO
Gene ID (Entrez):
351, 54226
Content And Storage:
-20°C
Form:
Liquid
Antigen: IL-10
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative; pH 7.2
Gene Accession No.: P22301
Gene Symbols: IL10
Immunogen: Recombinant human Interleukin 10.
Quantity: 500 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Applications: ELISA, Flow Cytometry, Neutralization
Clone: JES3-9D7
Conjugate: Unconjugated
Gene: IL10
Gene Alias: CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Host Species: Rat
Purification Method: purified
Regulatory Status: RUO
Gene ID (Entrez): 3586
Content And Storage: -20°C
Form: Liquid
Antigen:
IL-10
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative; pH 7.2
Gene Accession No.:
P22301
Gene Symbols:
IL10
Immunogen:
Recombinant human Interleukin 10.
Quantity:
500 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
ELISA, Flow Cytometry, Neutralization
Clone:
JES3-9D7
Conjugate:
Unconjugated
Gene:
IL10
Gene Alias:
CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
Host Species:
Rat
Purification Method:
purified
Regulatory Status:
RUO
Gene ID (Entrez):
3586
Content And Storage:
-20°C
Form:
Liquid