Chondroitin Sulfate Mouse anti-Human, Unlabeled, Clone: 9.2.27, BD

Description

• Tumor cells display a variety of antigens which have been defined by antibodies
• Antibodies that specifically react with tumor-associated antigens are useful in understanding the biology of particular tumor types
• Monoclonal antibody 9.2.27, produced against a human melanoma cell extract, reacts with a chondroitin sulfate proteoglycan
• Proteoglycans including chondroitin sulfate, keratan sulfate, dermatan sulfate and heparan sulfate are major components of the extracellular matrices of many animal cell types
• Clone 9.2.27 has been shown to react with human melanoma cells, glioma cells, and proliferating brain endothelial cells
• It did not react with fetal melanocytes, neuroblastoma LA-N-1 cells or a variety of carcinoma, lymphoid, and fibroblastoid cell lines
• Additionally, neither white or gray matter from the medulla oblongata, cerebellum or spinal cord of a normal human adult reacted with 9.2.27
• Clone 9.2.27 has also been used in functional studies to investigate the role of chondroitin sulfate proteoglycans in human tumor cell systems
• It has been shown to block melanoma cell spreading, exhibit antiproliferative effects on glioma cells in vitro, and suppress glioma tumor growth in athymic nude mice models
• A soluble extract derived from M14 human melanoma cells bound to lens culinaris lectin-Sepharose and depleted of fibronectin was used as immunogen
• Host Species: Mouse Clone: 9.2.27 Isotype: IgG2a Species Reactivity: Human Immunogen: Human Melanoma Cells Electron Microscopy, Flow Cytometry, Immunofluorescence, Immunoprecipitation