BDB556432
Cytochrome c Mouse, Unlabeled, Clone: 6H2.B4, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB556432-Each-of-1 | In Stock | ₹ 30,929.94 |
BDB556432 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 30,929.94
GST (18%): ₹ 5,567.389
Total Price: ₹ 36,497.329
Antigen
Cytochrome c
Classification
Monoclonal
Concentration
0.5mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Rat cytochrome c
Quantity
0.1 mg
Research Discipline
Cell Biology
Target Species
Human, Mouse, Rat
Isotype
IgG1 κ
Applications
Immunoprecipitation
Clone
6H2.B4
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Description
- A cytochrome is an electron-transporting protein that contains a heme prosthetic group
- Cytochromes have been known to be essential components of the mitochondrial respiratory chain since 1925
- The iron atom of the heme group in cytochromes alternates between a reduced ferrous (+2) state and an oxidized ferric (+3) state during electron transport in oxidative phosphorylation
- Cytochromes are classified into four groups (a, b, c and d) according to spectrochemical characteristics, and there are five cytochromes between coenzyme QH2 and O2 in the electron transport chain
- Cytochrome c is a water-soluble protein that either promotes cell survival or death, depending upon its intracellular location
- In healthy cells, it is a peripheral membrane protein of the mitochondria that transports electrons from the coenzyme QH2 cytochrome c reductase complex to the cytochrome c oxidase complex
- When proapoptotic stimuli induce breakdown of the mitochondria, cytochrome c is released to the cytosol where it functions in the activation of caspases that trigger apoptosis
- The 6H2.B4 monoclonal antibody has been reported to recognize the native and not the denatured form of rat, mouse, and human cytochrome c
- Furthermore, studies utilizing competitive ELISA indicate that mAb 6H2.B4 binds to a region around residue 62 of rat cytochrome c
- The 6H2.B4 monoclonal antibody is not useful for western blot analysis
- For the western blot application, clone 7H8.2C12 (Mfr.no
- 556433) would be recommended
- Suggested positive controls for detecting cytochrome c include P388D mouse lymphoma cells (ATCC CCL 46), HeLa human carcinoma cells (ATCC CCL2), Jurkat T leukemia cells (ATCC TIB152) and NIH 3T3 mouse fibroblast cells (ATCC CRL 1658)
- This antibody is routinely tested by immunoprecipitation and immunofluorescent imaging
- Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature
- Host Species: Mouse Clone: 6H2.B4 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Rat cytochrome c Immunoprecipitation
Compare Similar Items
Show Difference
Antigen: Cytochrome c
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Rat cytochrome c
Quantity: 0.1 mg
Research Discipline: Cell Biology
Target Species: Human, Mouse, Rat
Isotype: IgG1 κ
Applications: Immunoprecipitation
Clone: 6H2.B4
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
Cytochrome c
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Rat cytochrome c
Quantity:
0.1 mg
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Rat
Isotype:
IgG1 κ
Applications:
Immunoprecipitation
Clone:
6H2.B4
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: Cytochrome c
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Synthetic Peptides of Pigeon Cytochrome C
Quantity: 0.1 mg
Research Discipline: Cell Biology
Target Species: Human, Mouse, Pigeon, Rat
Isotype: IgG2b κ
Applications: Western Blot
Clone: 7H8.2C12
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
Cytochrome c
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Synthetic Peptides of Pigeon Cytochrome C
Quantity:
0.1 mg
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Pigeon, Rat
Isotype:
IgG2b κ
Applications:
Western Blot
Clone:
7H8.2C12
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: Perforin
Classification: Monoclonal
Concentration: 0.5mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Purified Granules from the Human Lymphoma Cell Line YT
Quantity: 0.1 mg
Research Discipline: Immunology
Target Species: Bovine, Human
Isotype: IgG2b κ
Applications: Flow Cytometry
Clone: ΔG9
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Antigen:
Perforin
Classification:
Monoclonal
Concentration:
0.5mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Purified Granules from the Human Lymphoma Cell Line YT
Quantity:
0.1 mg
Research Discipline:
Immunology
Target Species:
Bovine, Human
Isotype:
IgG2b κ
Applications:
Flow Cytometry
Clone:
ΔG9
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Antigen: Perforin
Classification: Monoclonal
Concentration: __
Formulation: __
Immunogen: Purified Granules from the Human Lymphoma Cell Line YT
Quantity: 100 Tests
Research Discipline: Immunology
Target Species: Human
Isotype: IgG2b
Applications: Flow Cytometry
Clone: ΔG9
Conjugate: PE
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
Perforin
Classification:
Monoclonal
Concentration:
__
Formulation:
__
Immunogen:
Purified Granules from the Human Lymphoma Cell Line YT
Quantity:
100 Tests
Research Discipline:
Immunology
Target Species:
Human
Isotype:
IgG2b
Applications:
Flow Cytometry
Clone:
ΔG9
Conjugate:
PE
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.