p53 with control Mouse, PE, Clone: G59-12, BD

Description

• p53 is a 53 kD nuclear phosphoprotein that acts as a tumor suppressor protein, and is involved in inhibiting cell proliferation when DNA damage occurs
• The gene for p53 is the most commonly mutated gene yet identified in human cancers
• Missense mutations occur in tumors of the colon, lung, breast, ovary, bladder and several other organs
• The mutant p53 is overexpressed in a variety of transformed cells and wild-type p53 forms specific complexes with several viral oncogenes including SV40 large T, E1B from adenovirus, and E6 from human papilloma virus
• Wild type p53 plays a role as a checkpoint protein for DNA damage during the G1/S-phase of the cell cycle
• G59-12 recognizes mutant and wild type human, rat and mouse p53 tumor suppressor protein
• Recombinant full-length human p53 was used as immunogen
• The G59-12 clone was originally characterized by western blot analysis, immunoprecipitation and immunohistochemical staining
• Clone MOPC-21 is a mouse IgG1 isotypecontrol
• The MOPC-21 antibody has unknown specificity.