BDB558220
DCIR Mouse anti-Human, Alexa Fluor 647, Clone: I3-612, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558220-Each-of-1 | In Stock | ₹ 31,956.66 |
BDB558220 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,956.66
GST (18%): ₹ 5,752.199
Total Price: ₹ 37,708.859
Antigen
DCIR
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Host Species
Mouse
Quantity
100 Tests
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
I3-612
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Description
- The I3-612 antibody reacts with DCIR, or dendritic cell immunoreceptor, a newly identified member of the calcium-dependent (C-type) lectin family
- DCIR is a type II membrane glycoprotein with a single carbohydrate recognition domain (CRD)
- Its cytoplasmic tail contains a consensus immunoreceptor tyrosine-based inhibitory motif (ITIM)
- It is expressed on monocytes, macrophages, B-lymphocytes, granulocytes, but not on NK or T cells
- DCIR is strongly expressed on dendritic cells derived from peripheral blood monocytes cultured in presence of GM-CSF and IL-4
- Down-regulation is observed on these with further maturation using TNF-α or LPS
- Reports describe the detection of two distinct inhibitory signals depending on its ITIM tyrosine residue
- Host Species: Mouse Clone: I3-612 Isotype: IgG1, κ Cross Reactivity: Human Flow Cytometry
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