IFN-Gamma Mouse anti-Human, BUV395, Clone: B27, BD

Description

• The B27 monoclonal antibody specifically binds to human interferon-γ (IFN-γ)
• IFN-γ is a potent multifunctional cytokine that is produced by several activated cell types including NK, NKT, CD4+TCRαβ+, CD8+TCRαβ+, and TCRγδ+ T cells
• IFN-γexerts its biological effects through specific binding to the high-affinity IFN-γ Receptor Complex comprised of IFN-γβ subunits
• In addition to its antiviral effects, IFN-γupregulates a number of lymphoid cell functions including the antimicrobial and antitumor responses of macrophages, NK cells, and neutrophils
• In addition, IFN-γcan exert strong regulatory influences on the proliferation, differentiation, and effector responses of B cell and T cell subsets
• These influences can involve IFN-γ’s capacity to boost MHC class I and II expression by antigen-presenting cells as well as to direct effects on B cells and T cells themselves
• Human IFN-γis a 14-18 kDa glycoprotein containing 143 amino acid residues
• B27 is a neutralizing antibody
• The use of B27 antibody for epitope mapping of human IFN-γ has been described
• The B27 antibody has been reported not to bind to denatured IFN-γ.