BDB563570
CD324 Mouse anti-Human, Alexa Fluor 488, Clone: 67A4, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB563570-Each-of-1 | In Stock | ₹ 19,491.00 |
BDB563570 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 19,491.00
GST (18%): ₹ 3,508.38
Total Price: ₹ 22,999.38
Antigen
CD324
Classification
Monoclonal
Conjugate
Alexa Fluor 488
Formulation
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen
Human Breast Tumor Cell Line
Quantity
50 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
67A4
Description
E-cadherin
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Related Products
Description
- The 67A4 monoclonal antibody recognizes the extracellular domain of human E-Cadherin (CD324)
- E-Cadherin is a 120-kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells
- There it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins
- In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation
- Its association with catenins is necessary for cell-to-cell adhesion
- These E-Cadherin/catenin complexes associate with cortical actin bundles at both the zonula adherens and the lateral adhesion plaques
- Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties
- E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas
- Increased expression of E-Cadherin in these cells reduces their invasiveness
- Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression
- Pluripotent stem cells express E-Cadherin
- Upon differentiation, an epithelial to mesenchymal transition results in the loss of E-cadherin expression and a gain in the expression of N-cadherin.
Compare Similar Items
Show Difference
Antigen: CD324
Classification: Monoclonal
Conjugate: Alexa Fluor 488
Formulation: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen: Human Breast Tumor Cell Line
Quantity: 50 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: 67A4
Description: E-cadherin
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Antigen:
CD324
Classification:
Monoclonal
Conjugate:
Alexa Fluor 488
Formulation:
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen:
Human Breast Tumor Cell Line
Quantity:
50 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
67A4
Description:
E-cadherin
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Antigen: CD324
Classification: Monoclonal
Conjugate: Alexa Fluor 647
Formulation: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen: Human Breast Tumor Cell Line
Quantity: 50 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: 67A4
Description: E-cadherin
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Antigen:
CD324
Classification:
Monoclonal
Conjugate:
Alexa Fluor 647
Formulation:
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen:
Human Breast Tumor Cell Line
Quantity:
50 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
67A4
Description:
E-cadherin
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Antigen: Perforin
Classification: Monoclonal
Conjugate: Alexa Fluor 647
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Purified Granules from the Human Lymphoma Cell Line YT
Quantity: 50 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: deltaG9
Description: PRF1; P1; PERF; PFN1; PFP; Perforin-1; Cytolysin; FLH2; HPLH2
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Bovine, Human
Isotype: IgG2b κ
Antigen:
Perforin
Classification:
Monoclonal
Conjugate:
Alexa Fluor 647
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Purified Granules from the Human Lymphoma Cell Line YT
Quantity:
50 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
deltaG9
Description:
PRF1; P1; PERF; PFN1; PFP; Perforin-1; Cytolysin; FLH2; HPLH2
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Bovine, Human
Isotype:
IgG2b κ
Antigen: EGF Receptor
Classification: Monoclonal
Conjugate: Alexa Fluor 647
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: __
Quantity: 50 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: EGFR.1
Description: EGFR; ERBB; ERBB1; HER1; mENA; PIG61
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG2b κ
Antigen:
EGF Receptor
Classification:
Monoclonal
Conjugate:
Alexa Fluor 647
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
__
Quantity:
50 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
EGFR.1
Description:
EGFR; ERBB; ERBB1; HER1; mENA; PIG61
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2b κ