CD134 Mouse anti-Human, PE-CF594, Clone: ACT35 (also known as Ber-ACT35), BD

Description

• The ACT35 monoclonal antibody specifically binds to CD134 which is also known as OX40
• The 35 kDa CD134 polypeptide is encoded by the TNFRSF4 gene
• CD134 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family
• CD134 is expressed on activated T lymphocytes, hematopoietic precursor cells and fibroblasts
• CD134 functions as a T cell costimulatory receptor when bound by OX40 Ligand/TNFSF4 that is expressed by antigen presenting cells
• CD134 thereby plays roles in T-cell activation as well as the regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells
• Analysis of the nucleotide sequence of the human TNFRSF4 cDNA reveals strong homology with the rat Tnfrsf4 cDNA sequence
• OX40 was clustered as CD134 in the Sixth International Workshop on Human Leukocyte Differentiation Antigens
• This antibody is conjugated to BD Horizon™ PE-CF594, which has been developed exclusively by BD Biosciences as a better alternative to PE-Texas Red™
• PE-CF594 excites and emits at similar wavelengths to PE-Texas Red™ yet exhibits improved brightness and spectral characteristics
• Due to PE having maximal absorption peaks at 496nm and 564nm, PE-CF594 can be excited by the blue (488-nm), green (532-nm) and yellow-green (561-nm) lasers and can be detected with the same filter set as PE-Texas Red™ (eg 610/20-nm filter).