CD279 (PD-1) Mouse, anti-Human, R718, Clone: EH12.1, BD Horizon™

Description

• The EH12.1 monoclonal antibody specifically binds to CD279 which is also known as Programmed cell death 1 (PD1)
• CD279 is an immunoregulatory receptor expressed on activated T cells, B cells, and myeloid cells
• It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region
• Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms
• PD-L1 and PD-L2 are ligands of CD279 and members of the B7 gene family
• CD279:PD-Ligands interaction inhibits T cell proliferation and cytokine secretion
• Reports suggest that the B7/CTLA-4 pathway primarily attenuates, limits, and/or terminates naïve T-cell activation in secondary lymphoid organs
• The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.