BDB566978

Stat5 (pY694) Mouse, anti-Human, R718, Clone: 47/STAT5(PY694), BD Phosflow™

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB566978-Each-of-1 In Stock ₹ 23,400.66

BDB566978 - Each of 1

₹ 23,400.66

In Stock

Quantity

1

Base Price: ₹ 23,400.66

GST (18%): ₹ 4,212.119

Total Price: ₹ 27,612.779

Antigen

Stat5 (pY694)

Classification

Monoclonal

Conjugate

R718

Quantity

25 Tests

Primary or Secondary

Primary

Content And Storage

Refrigerate Upon Arrival

Applications

Flow Cytometry

Clone

47/STAT5(PY694)

Host Species

Mouse

Regulatory Status

RUO

Target Species

Human

Form

Liquid

Description

  • Stat (Signal transducer and activators of transcription) proteins mediate the biological activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors
  • Ligand-receptor interaction activates constitutively-associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation
  • Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes
  • Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner
  • Stat5 has been characterized and shown to be encoded by two separate genes, Stat5a and Stat5b, which share over 90% identity at the amino acid level
  • Stat5a has been shown to be involved in lactogenesis and mammary development, while Stat5b has been shown to be involved in growth hormone signaling and liver gene expression
  • Both Stat5a and Stat5b are involved in IL-2 induced peripheral T cell proliferation
  • The peptide hormone, prolactin, binds to the prolactin receptor (PRLR) to initiate the lactogenic response
  • There are at least three forms of PRLR| however, only the long form activates the 92-kDa Stat5 protein by inducing phosphorylation at Y694
  • Once phosphorylated, Stat5 becomes an essential transcription factor which binds to the β-casein gene promoter
  • The presence of an SH2 domain within Stat5 suggests that it may directly interact with protein tyrosine kinases (PTKs) such as JAK2
  • The 47 monoclonal antibody recognizes the phosphorylated Y694 of Stat5a
  • The homologous phosphorylation site in Stat5b is Y699.

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Antigen:
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