Granzyme A Mouse, anti-Human, R718, Clone: CB9, BD Horizon™

Description

• The CB9 monoclonal antibody specifically recognizes Granzyme A (GrA, GzmA or Gzm A) which is also known as CTL tryptase, Cytotoxic T-lymphocyte-associated serine esterase-3 (CTLA3), Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, or Hanukah factor serine protease (HFSP)
• Granzyme A belongs to a family of effector proteases that include five different granzymes that play key roles in innate and adaptive immune responses to pathogens and transformed cells: Granzymes A, B, H, K and M
• Granzyme A is a ∼28 kDa neutral serine protease that is encoded by GZMA
• It is expressed in the cytotoxic granules of natural killer (NK) cells, NKT cells, cytotoxic αâ T cells and ãä T cells
• Granzyme A participates in innate and adaptive immune responses
• After gaining access into target cells, Granzyme A cleaves various peptide substrates after lysine or arginine residues and can induce caspase‐independent cell death reflected in single-stranded DNA damage as well as rapid loss of cell membrane integrity and mitochondrial transmembrane potential.