Fibronectin Mouse, Unlabeled, Clone: 10, BD

Description

• The 240kDa dimeric fibronectin protein exists in two forms: a soluble protomer in body fluids and an insoluble multimer in the extracellular matrix
• The latter is the primary functional form and creates a substrate for cell migration, a role which makes fibronectin vital to embryogenesis and wound response
• Fibronectin mediates cytoskeletal organization, cell attachment, and cellular signaling through interactions with cellular receptors
• Although various isoforms of fibronectin are derived by alternative splicing, they share a common N-terminus which is a critical region for cell surface binding in an initial step of multimer assembly
• Further polymerization steps are regulated by fibronectin/integrin interactions and result in generation of the complex fibrils that constitute the fibronectin matrix
• Host Species: Mouse Clone: 10 Isotype: IgG1 Species Reactivity: Human Immunogen: Human Fibronectin Formula Weight [Chemical]: 240kDa Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting