PKCα Mouse, Unlabeled, Clone: 3/PKC, BD

Description

• The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion
• At least eleven isozymes have been described
• These proteins are products of multiple genes and alternative splicing
• PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V)
• The N-terminal half containing C1, C2, V1, and V2 constitutes the regulatory domain and interacts with PKC activators Ca 2+ ;, phospholipid, diacylglycerol, or phorbol ester
• However, the novel PKC (nPKC) subfamily members ( δ, ε, η, and θ isoforms) and the atypical PKC (aPKC) subfamily members (ζ, ι, and λ isoforms) are Ca 2+ ; independent and lack the C2 domain
• The aPKC members are unique in that their activity is independent of diacylglycerols and phorbol esters
• They also lack one repeat of the cysteine-rich sequences that are conserved in cPKC and nPKC
• The C-terminal region of PKC contains the catalytic domain
• The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters and growth factors
• Overexpression of PKCα has been reported to lead to an enhanced growth rate and induces the phosphorylation of two cellular proteins of 52kDa and 90kDa
• Host Species: Mouse Clone: 3 Isotype: IgG2b Species Reactivity: Rat Immunogen: Human PKCα aa
• 270-427 Formula Weight [Chemical]: 82kDa Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting