GRB2 Mouse, Unlabeled, Clone: 81, BD

Description

• Growth-factor Receptor-Bound Protein 2 (GRB2) was isolated by using the EGF receptor C-terminus as a probe in the screening of λgt11 expression libraries
• This 24kDa GRB2 protein is ubiquitously expressed and consists of one SH2 domain flanked by two SH3 domains
• Its ability to bind proteins through these domains has prompted much investigation of its role as an adaptor protein
• Sos, a Ras GDP/GTP exchange protein, is constitutively bound to the SH3 domain of GRB2
• Following growth factor stimulation, receptor tyrosine kinases autophosphorylate, creating a binding site for the GRB2 SH2 domain
• Alternatively, GRB2 interacts with the receptor-bound active Shc protein.Through these interactions, the GRB2/Sos complex is translocated to the membrane where Sos activates membrane-bound Ras to initiate the Ras signaling pathway
• Other proteins that similarly interact with GRB2 include Cbl, PTP1D, and Dynamin
• However,the mechanisms through which these associations impact cellular responses remain to be discovered
• Host Species: Mouse Clone: 81 Isotype: IgG1 Species Reactivity: Rat Immunogen: Rat GRB2 aa
• 1-217 Formula Weight [Chemical]: 24kDa Bioimaging, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting