CD220 Mouse, Unlabeled, Clone: 46, BD

Description

• Insulin Receptor (IR) is a transmembrane receptor tyrosine kinase which, upon insulin binding, initiates a cascade of events, including autophosphorylation, phosphorylation of cellular protein substrates, glucose transport, and glycogen synthesis
• IR is synthesized as a large glycosylated precursor that is cleaved upon maturation into a 130kDa α-subunit with kinase activity and a 95kDa β-subunit
• The active Insulin Receptor is a heterotetramer of homologus α and β subunits joined by disulfide bonds
• Among the major cytosolic substrates of the Insulin Receptor are IRS-1 and -2, β-Adrenergic receptor, and pp15 (adipocyte lipid-binding protein, ALBP)
• Autophosphorylation of the IR recruits IRS-1 and -2 to the phosphotyrosines
• Subsequently, the phosphorylated IRS-1 and -2 act as docking sites for other signaling proteins like PI3-Kinase, Shc, PTP1D, Nck, etc
• In addition, the phosphatase LAR is tightly associated with the IR and LAR becomes activated after insulin stimulation dephosphorylating the IR and its substrates
• Therefore, LAR provides a turn-off mechanism in insulin signaling
• Host Species: Mouse Clone: 46 Isotype: IgG1 Species Reactivity: Mouse Immunogen: Human Insulin pro-receptor β subunit 1006-1144 Formula Weight [Chemical]: 95kDa Immunofluorescence, Immunoprecipitation, Western Blotting