Ubc9 Mouse, Unlabeled, Clone: 50, BD

Description

• Progression of the mammalian cell cycle is primarily regulated by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins
• Ubiquitin, a soluble protein of 76 amino acids, is enzymatically attached to an e-NH2-Lys in a target protein
• Ubiquitination is a hallmark for rapid protein degradation of the target protein in the proteosome (a cytoplasmic complex of proteases)
• Human homologs of the yeast ubiquitin-conjugating enzymes (Ubc) have been reported, including Ubc9
• Ubc9 is 158 amino acids with an apparent molecular weight of 18kDa
• Although ubiquitously expressed, the highest levels of Ubc9 are found in testis and thymus
• Ubc9 was localized to the synaptonemal complex in male mouse sex chromosomes
• Furthermore, Ubc9 interacts with the recombination protein Rad51, thus suggesting an important role for Ubc9 during meiosis.