BRUCE Mouse, Unlabeled, Clone: 4, BD

Description

• Selective proteolysis is essential for the modulation of key cellular processes such as cell cycle progression
• However, unlike other post-translational events, proteolysis is irreversible and therefore must occur in unidirectional cellular pathways
• In eukaryotes, proteolysis is mediated primarily by the ubiquitin pathway
• This pathway designates proteins for degradation by the proteasome, a multicatalytic protease complex
• The ubiquitin pathway is a multistep system that tags proteins for degradation via the attachment of ubiquitin molecules to the target
• This attachment is mediated by the ubiquitin activating/conjugating enzymes E1, E2, E3, and BRUCE
• BRUCE (BIR Repeat containing Ubiquitin-Conjugating Enzyme) is a novel enzyme that associates with the Golgi and the vesicular system
• It contains a UBC (ubiquitin conjugating enzyme) domain, which is essential for catalysis, and a BIR (baculovirus inhibitor of apoptosis repeat) motif
• BIR motifs are also found within inhibitor of apoptosis proteins (IAP) and are critical for anti-apoptotic activity
• Therefore, BRUCE may function to both mediate ubiquitin-dependent proteolysis and contribute to anti-apoptotic cellular pathways
• Host Species: Mouse Clone: 4 Isotype: IgG1 Species Reactivity: Human Immunogen: Mouse BRUCE aa
• 372-571 Formula Weight [Chemical]: 528kDa Immunofluorescence, Western Blotting