BDB612393
eNOS (pS1177), Phospho-Specific Mouse anti-Human, Unlabeled, Clone: 19, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB612393-Each-of-1 | In Stock | ₹ 57,410.76 |
BDB612393 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 57,410.76
GST (18%): ₹ 10,333.937
Total Price: ₹ 67,744.697
Antigen
eNOS (pS1177), Phospho-Specific
Classification
Monoclonal
Concentration
250μg/mL
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen
Human eNOS (pS1177)
Quantity
150 μg
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgG1
Applications
Western Blot
Clone
19
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
Related Products
Description
- Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO)
- NO is a short-lived radical that transmits signals involved in vasorelaxation, neurotransmission, and cytotoxity
- In neurons and endothelial cells, constitutive NOS (cNOS) is activated by agonists that increase intracellular Ca 2+ ; levels and enhance calmodulin binding
- Neuronal NOS (nNOS) and endothelial NOS (eNOS) have recognition sites for NADPH, FAD, FMN, and calmodulin
- eNOS has a unique N-myristylation consensus sequence that may explain its membrane localization
- Various protein kinases have been implicated in regulation of eNOS activity, including AMPK, PKA, PKB/Akt, PKC, and CaM Kinase II
- During VEGF stimulation, eNOS is transiently phosphorylated at Ser-1177 by PKB/akt and dephosphorylated at Thr-495
- At later time points, VEGF stimulation leads to an increase in Thr-495 phosphorylation mediated by PKC and a decrease in Ser-1177 phosphorylation
- In addition, Ser-633 and Ser-1177 are phosphorylated by PKA and PKG in vitro
- Thus, eNOS activity may be regulated through complex phosphorylated events mediated by multiple kinases at various phosphorylation sites
- Human endothelial cells are routinely tested as a positive control for eNOS (pS1177) mAb
- 100% homology is detected for immunogen sequence in human, mouse, rat, dog and bovine
- Cross-reactivity with other species is expected but not confirmed
- Flow Cytometry, Western Blotting
Compare Similar Items
Show Difference
Antigen: eNOS (pS1177), Phospho-Specific
Classification: Monoclonal
Concentration: 250μg/mL
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen: Human eNOS (pS1177)
Quantity: 150 μg
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG1
Applications: Western Blot
Clone: 19
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
eNOS (pS1177), Phospho-Specific
Classification:
Monoclonal
Concentration:
250μg/mL
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen:
Human eNOS (pS1177)
Quantity:
150 μg
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG1
Applications:
Western Blot
Clone:
19
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: Paxillin
Classification: Monoclonal
Concentration: 1.0mg/mL
Formulation: Aqueous buffered solution containing glycerol and ≤0.09% sodium azide.
Immunogen: Chicken Paxillin aa. 1-557
Quantity: 100 μg
Research Discipline: Cell Biology
Target Species: Canine, Chicken, Human, Mouse, Rat
Isotype: IgG1
Applications: Western Blot
Clone: 349
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Paxillin
Classification:
Monoclonal
Concentration:
1.0mg/mL
Formulation:
Aqueous buffered solution containing glycerol and ≤0.09% sodium azide.
Immunogen:
Chicken Paxillin aa. 1-557
Quantity:
100 μg
Research Discipline:
Cell Biology
Target Species:
Canine, Chicken, Human, Mouse, Rat
Isotype:
IgG1
Applications:
Western Blot
Clone:
349
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: p120 Catenin (pY228)
Classification: Monoclonal
Concentration: 250μg/mL
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen: Mouse p120 Catenin (pY228)
Quantity: 50 μg
Research Discipline: Cell Biology
Target Species: Human, Mouse, Rat
Isotype: IgG1
Applications: Western Blot
Clone: 21A
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
p120 Catenin (pY228)
Classification:
Monoclonal
Concentration:
250μg/mL
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen:
Mouse p120 Catenin (pY228)
Quantity:
50 μg
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Rat
Isotype:
IgG1
Applications:
Western Blot
Clone:
21A
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: JNK/SAPK (pT183/pY185)
Classification: Monoclonal
Concentration: 250μg/mL
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human JNK/SAPK (pT183/pY185) Peptide
Quantity: 50 μg
Research Discipline: Cell Biology
Target Species: Human, Mouse, Rat
Isotype: IgG1
Applications: Western Blot
Clone: 41
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
JNK/SAPK (pT183/pY185)
Classification:
Monoclonal
Concentration:
250μg/mL
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human JNK/SAPK (pT183/pY185) Peptide
Quantity:
50 μg
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Rat
Isotype:
IgG1
Applications:
Western Blot
Clone:
41
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.